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Bisocor 2.5mg Tablet 1 Strip
Bisocor tablets are used for the treatment of:
- Hypertension
- Angina
- Moderate to severe heart failure
Note: Bisocor is not suitable for emergency management of hypertensive crises.
Use this medication as prescribed by a registered physician.
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✅ Description:
Bisoprolol Fumarate is a highly selective ß1 adrenergic receptor blocker, displaying the greatest affinity for ß1 receptors compared to other beta-blockers. It selectively inhibits ß1 receptors in the heart and vascular smooth muscle, reducing heart rate and cardiac output, which lowers arterial blood pressure. Unlike non-selective ß-blockers, Bisoprolol does not adversely affect lipid metabolism or HDL-cholesterol levels during long-term use.
The pharmacokinetics of Bisoprolol allow for once-daily dosing, ensuring consistent plasma concentration levels with minimal variability.
- Absorption & Bioavailability: Over 90% of Bisoprolol is absorbed from the gastrointestinal tract, with an absolute bioavailability of 88% due to minimal first-pass metabolism (<10%). Food does not affect its absorption.
- Distribution: Bisoprolol is widely distributed, with a medium distribution volume of 3.5 L/kg.
- Metabolism: It undergoes oxidative metabolism without conjugation, and the resulting polar metabolites are excreted renally. The primary metabolic pathway involves CYP3A4 (~95%), with minor involvement of CYP2D6.
- Elimination: Bisoprolol clearance is balanced between renal excretion of the unchanged drug (~50%) and hepatic metabolism (~50%). The elimination half-life is 10-12 hours.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Pregnancy & Lactation
Pregnancy:
- Studies in animals suggest that Bisoprolol is not teratogenic at doses up to 375 times the maximum human dose. However, it showed fetal toxicity at higher doses.
- Use during pregnancy only if the potential benefit outweighs the risk to the fetus.
Lactation:
- Bisoprolol passes into animal milk in small amounts (<2%). It is unclear if it is excreted in human milk. Nursing mothers should discontinue breastfeeding if Bisoprolol use is necessary.
✔️ Dosage & Administration
Adults:
For mild to moderate hypertension, the dosage should be tailored to the individual:
- Start with 5 mg once daily, either alone or combined with a diuretic.
- If 5 mg is insufficient, increase to 10 mg daily, and if necessary, to 20 mg daily.
- Allow at least two weeks between dose adjustments. Doses above 20 mg daily offer limited additional benefits.
Children:
The safety and efficacy of Bisoprolol in children have not been established.
Renal or Hepatic Impairment:
- For patients with liver dysfunction (e.g., hepatitis or cirrhosis) or renal impairment (creatinine clearance <40 mL/min), start with 5 mg daily.
- Titrate doses cautiously to avoid drug accumulation. Bisoprolol is not dialyzable, so replacement is unnecessary for dialysis patients.
Elderly:
Dose adjustments are generally not required unless significant renal or hepatic impairment is present.
Use this medication as prescribed by a registered physician.
✔️ Side effects may vary among individuals and include:
- Fatigue, dizziness, headache
- Gastrointestinal disturbances such as nausea, vomiting, diarrhea, constipation, or abdominal pain
- Cold or numb extremities (e.g., hands and feet)
- Muscle weakness or cramps
- Bradycardia (slower than normal heart rate)
- Bronchospasms cause breathing difficulties, particularly in people with asthma or COPD
✔️ Interactions
- Other β-Blockers: Avoid combining Bisocor with other beta-blockers.
- Catecholamine-Depleting Drugs: Medications like reserpine or guanethidine may enhance the sympathetic-blocking effect of Bisocor, requiring close monitoring.
- Centrally Acting Antihypertensives: Caution is needed when combining Bisocor with drugs like clonidine due to the risk of rebound hypertension. If discontinuing clonidine, stop Bisocor several days before to avoid exacerbation.
- Antiarrhythmic Agents: Use Bisocor carefully with myocardial depressants or A-V conduction inhibitors, such as certain calcium channel blockers (e.g., verapamil, diltiazem) or antiarrhythmics (e.g., disopyramide).
- Calcium Channel Blockers: The combination of Bisocor and calcium channel blockers with negative inotropic effects may lead to bradycardia, severe hypotension, or cardiac failure in patients with impaired ventricular function.
✔️ Bisocor should not be used in patients with:
- Cardiogenic shock
- Overt heart failure
- Second or third-degree A-V block
- Right ventricular failure due to pulmonary hypertension
- Sinus bradycardia
✔️ Precautions & Warnings
- Use with caution in patients with renal or hepatic impairment.
- Patients with a history of severe anaphylactic reactions may have heightened sensitivity to allergens and may not respond to usual epinephrine doses.
✔️ Storage Conditions
- Store in a dry place, away from heat and light.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
