Sergel 20mg is used to treat various digestive conditions such as Gastroesophageal Reflux Disease (GERD), Peptic Ulcers, and Zollinger-Ellison Syndrome.
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It is generally considered safe to drink alcohol while taking Sergel 20, but there can be some potential interactions and side effects to be aware of.
If you are pregnant or planning to become pregnant, it's important to discuss the use of esomeprazole with your doctor. They can help you determine if the medication is appropriate for you and help you weigh the potential risks and benefits for your individual situation.
If you are breastfeeding, it's important to discuss the use of sergel 20mg with your doctor.
If you experience side effects while taking Sergel 20mg that affect your ability to drive, it's important to avoid operating heavy machinery or driving until the symptoms have resolved. If the symptoms persist or become more severe, it's important to talk to your doctor as soon as possible.
Esomeprazole is generally considered safe for most people when taken as directed. If you have kidney disease or impaired kidney function, it's important to talk to your doctor about the use of Esomeprazole20 /Sergel 20.
Esomeprazole is generally considered safe for most people when taken as directed. However, the safety of esomeprazole in individuals with liver disease or impaired liver function may vary.
Esomeprazole 20mg is used to treat various digestive conditions, including:
Esomeprazole is typically used once daily, first thing in the morning. It may be consumed with or without meals. Take one dose of esomeprazole in the morning and one in the evening if you take it twice a day. Take pills and capsules whole, followed by a glass of water (non-fizzy).
A medication called Sergel 20 lowers the amount of acid your stomach produces. Heartburn, acid reflux, and issues with your food pipe are all treated with it. Stomach ulcers can also be prevented and treated with it. As directed by your doctor, take Sergel 20.
Sergel is a proton pump inhibitor that inhibits stomach acid production by inhibiting the H+/K+-ATPase in the gastric parietal cell specifically. Esomeprazole (S-isomer of omeprazole) is the first proton pump inhibitor with a single optical isomer that provides superior acid control than racemic proton pump inhibitors.
Sergel capsules include an enteric-coated pellet formulation of esomeprazole magnesium for absorption. Peak plasma levels (Cmax) occur around 1.5 hours after oral dosing (Tmax). When the dosage is increased, the Cmax increases proportionately, and the area under the plasma concentration-time curve (AUC) increases thrice from 20 to 40 mg. The systemic bioavailability is around 90% with repeated once-daily dosage, compared to 64% after a single dose. When compared to fasting circumstances, the AUC following a single dosage of esomeprazole is reduced by 33-53 percent after food ingestion. Take esomeprazole at least one hour before meals.
Sergel is linked to plasma proteins in 97 percent of cases. Over a concentration range of 2 20 mmol/L, plasma protein binding is constant. In healthy individuals, the apparent volume of distribution at a steady state is around 16 L.
Metabolism: The cytochrome P450 (CYP) enzyme system extensively metabolizes esomeprazole in the liver. Esomeprazole metabolites have no anti-secretory action. The CYP2C19 isoenzyme, which produces the hydroxy and dimethyl metabolites, is responsible for the majority of esomeprazole metabolism. The remainder is dependent on CYP3A4, which produces the sulphonyl metabolite.
Take Sergel 20mg as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It must be taken during or just after meals.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and severity of infection. Do not stop therapy or skip doses in between the therapy to achieve better control over the infection.
CYP2C19 and CYP3A4 substantially metabolize esomeprazole in the liver. Esomeprazole is unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4, according to in vitro and in vivo investigations. There should be no clinically significant interactions with medicines processed by these CYP enzymes. Esomeprazole has no clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin, according to drug interaction studies.
Sergel may interact with the main Esomeprazole metabolizing enzyme, CYP2C19. Co-administration of Esomeprazole 30 mg with diazepam, a CYP2C19 substrate, resulted in a 45 percent reduction in diazepam clearance. Increased diazepam plasma levels have been reported 12 hours after treatment and beyond. Esomeprazole works by inhibiting stomach acid output. As a result, Esomeprazole may impair medication absorption in cases where stomach pH is a key driver of bioavailability (e.g., ketoconazole, iron salts, and digoxin).
Co-administration of oral contraceptives, diazepam, phenytoin, or quinidine does not appear to alter Esomeprazole's pharmacokinetic profile.
Combination Therapy with Clarithromycin: Co-administration of esomeprazole, clarithromycin, and amoxicillin has resulted in increases in esomeprazole and 14-hydroxyclarithromycin plasma levels.
Esomeprazole is not recommended for those who have a history of hypersensitivity to any of the formulations.
In pregnant women, there are no appropriate and well-controlled trials. Teratogenic effects have not been discovered in animal investigations. Esomeprazole excretion in milk has not been examined. If the use of esomeprazole is deemed necessary, breastfeeding should be stopped.
Store in a dry location at a temperature not exceeding 30°C. Keep out of direct sunlight and dampness. Keep out of children's reach.
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