Dexlansoprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by selectively inhibiting the H⁺/K⁺-K-ATPase enzyme in the gastric parietal cells.
This inhibition blocks the final step of acid production, thereby reducing gastric acidity effectively.
It is the R-enantiomer of lansoprazole, formulated as a Dual Delayed Release (DDR) capsule containing two types of enteric-coated granules that dissolve at different pH levels.
This unique release profile results in two plasma concentration peaks — the first within 1–2 hours, and the second within 4–5 hours after administration.
Dexlansoprazole is extensively metabolized in the liver and primarily excreted through urine.
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Proper Packaging
Therapeutic Class: Proton Pump Inhibitor (PPI)
Dexlansoprazole Capsule:
Healing of EE: 60 mg once daily for up to 8 weeks
Maintenance of healed EE / Heartburn relief: 30 mg once daily
Symptomatic non-erosive GERD: 30 mg once daily for 4 weeks
Dexlansoprazole MUPS:
Maintenance of healed EE / Heartburn relief:
30 mg once daily for 6 months (adults) or 16 weeks (age 12–17 years)
Symptomatic non-erosive GERD:
30 mg once daily for 4 weeks
Children (below 12 years): Safety and efficacy not established.
Geriatric: No dose adjustment required.
Renal Impairment: No adjustment necessary.
Hepatic Impairment:
Mild: No dose adjustment needed.
Moderate: Maximum recommended dose — 30 mg daily.
Can be taken with or without food.
Swallow the capsule whole, or open and sprinkle the intact granules on one tablespoon of applesauce, then swallow immediately without chewing.
If a dose is missed, take it as soon as possible. Skip if it’s close to the next dose—do not double the dose.
With Medicines:
Atazanavir, Warfarin, Tacrolimus, Clopidogrel, and Methotrexate.
With Food / Others:
No significant data available.
Contraindicated in patients with known hypersensitivity to Dexlansoprazole or any component of its formulation.
Pregnancy Category B: No adequate, well-controlled studies in pregnant women.
Safety during lactation has not been established.
Rule out gastric malignancy before initiating therapy.
Risk of Clostridium difficile-associated diarrhea, bone fracture, and hypomagnesemia with long-term use.
Caution is advised with concurrent Methotrexate therapy.
Store below 30°C, in a cool, dry place away from light.
Keep out of reach of children.
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