Anleptic 200 CR 10Pcs

Carbamazepine is indicated for-
Indications of Anleptic 200 CR Tablet

Analeptic 200 CR Tablet is indicated for-

partial and secondary generalized tonic-clonic seizures

Primary generalized tonic-clonic seizures

Trigeminal neuralgia

Prophylaxis of bipolar disorder

Pharmacology of Anleptic 200 CR Tablet

Carbamazepine inhibits activity in the thalamic nucleus ventralis, limits synaptic propagation of excitatory impulses, and diminishes the summation of temporal stimuli leading to neuronal discharge by reducing the influx of Na ions across the cell membrane, among other processes. It increases the secretion of antidiuretic hormone (ADH) and enhances its ability to promote water reabsorption.

Anleptic 200 CR Tablet Dosage & Administration

Epilepsy:

Adults and children over 12 years of age- Initial: Either 200 mg b.i.d. for tablets and controlled-release tablets or 1 teaspoon q.i.d. for suspension (400 mg/day). Increase at weekly intervals by adding up to 200 mg/day using a b.i.d or a t.i.d. or q.i.d. regimen of either formulation until the optimal response is obtained.

Children 12-15 years of age- Dosage generally should not exceed 1000 mg daily, and 1200 mg daily in patients above 15 years of age. Doses up to 1600 mg daily have been used in adults in rare instances. Maintenance: usually 800-1200 mg daily.

Children 6-12 years of age- Initial: Either 100 mg b.i.d. for tablets or controlled-release tablets, or 1/2 teaspoon q.i.d. for suspension (200 mg/day). Increase at weekly intervals by adding up to 100 mg/day using a b.i.d. or a t.i.d.or q.i.d. regimen of either formulation until the optimal response is obtained. Dosage generally should not exceed 1000 mg daily. Maintenance: usually 400-800 mg daily.

Children under 6 years of age- Initial: 10-20 mg/kg/day b.i.d.or t.i.d. as tablets, or q.i.d. as suspension. Increase weekly to achieve optimal clinical response administered t.i.d. or q.i.d. Maintenance: Ordinarily, optimal clinical response is achieved at daily doses below 35 mg/kg. If the satisfactory clinical response has not been achieved, plasma levels should be measured to determine whether or not they are in the therapeutic range. No recommendation regarding the safety of Carbamazepine for use at doses above 35 mg/kg/24 hours can be made.

Combination therapy: Carbamazepine may be used alone or with other anticonvulsants. When added to existing anticonvulsant therapy, the drug should be added gradually while the other anticonvulsants are maintained or gradually decreased, except phenytoin, which may have to be increased.

Trigeminal Neuralgia: Initial: On the first day, either 100 mg b.i.d. for tablets or controlled-release tablets, or 1/2 teaspoon q.i.d. for suspension, for a total daily dose of 200 mg. This daily dose may be increased by up to 200 mg/day using increments of 100 mg every 12 hours for tablets or controlled-release tablets, or 50 mg (1/2 teaspoon) q.i.d. for suspension, only as needed to achieve freedom from pain. A total dose of 1200 mg daily shouldn't be exceeded. Maintenance: Control of pain can be maintained in most patients with 400-800 mg daily. However, some patients may be maintained on as little as 200 mg daily, while others may require as much as 1200 mg daily. At least once every 3 months throughout the treatment period, attempts should be made to reduce the dose to the minimum effective level or even to discontinue the drug. The tablets or syrup can be taken without regard to meals.

Interaction of Anleptic 200 CR Tablet

Within the first two months of Anleptic 200 CR Tablet medication, galactorrhoea has been recorded in a small number of women using oral contraceptives. Carbamazepine may interact with hepatic enzyme inducers like Carbamazepine and Phenytoin by enhancing Carbamazepine metabolism. As a result, an increase in Anleptic 200 CR Tablet dosage may be necessary.

Contraindications of Anleptic 200 CR Tablet

If you are allergic to one or more of the substances in this drug, you should not use it. It is also ineligible to be used in the following circumstances:

Problems with the heart's electrical message routes (atrioventricular block)

Bone marrow has a history of producing fewer blood cells (bone marrow depression)

Porphyrias are inherited blood illnesses.

Tricyclic antidepressants (TCAs) allergy

People who have recently taken a monoamine oxidase inhibitor antidepressant (MAOI)

Side Effects

Common side effects are dizziness, drowsiness, ataxia, dry mouth, abdominal pain, nausea, vomiting, anorexia, leukopenia, proteinuria, bradycardia, heart failure, and hypotension. Erythema rash and aplastic anemia can also be seen.

The most serious adverse reactions have been observed in the hematopoietic system, skin and cardiovascular system. The most commonly observed adverse reactions, especially in the initial stages of treatment, are dizziness, drowsiness, instability, nausea and vomiting. This drug can increase sensitivity to sunlight. If an increase in sensitivity is observed, avoid exposure to sunlight, sun lamps or tanning booths. Sunscreen or protective clothing can help you stay outdoors for long periods of time.

Pregnancy & Lactation

D is the pregnancy category. Breast milk contains carbamazepine and its epoxide metabolite. Because of the risk of major side effects, a choice should be taken about whether to stop nursing or stop taking the medication.

Precautions & Warnings

This medicine can cause vertigo and drowsiness. Special precautions must be taken when performing potentially hazardous activities such as the conduct or operation of the machines.

This medicine can cause skin reactions. If a skin rash, skin, itching or another unexplained skin reaction is seen when taking this medicine, the worried doctor must be informed immediately.

This medicine can rarely cause liver problems. For this reason, consultation with the doctor is necessary if it is inexplicable, yellowing of the skin or eyes, extraordinarily dark urine, nausea and vomiting, abdominal pain, and a loss of appetite or flulike symptoms.

Carbamazepine decreases blood levels of hormonal contraceptives containing estrogen and/or progesterone, which can make ineffective contraceptives or result in innovative bleeding.

Women who take this medicine require a contraceptive containing at least 50 micrograms of estrogen, or the use of non-hormonal contraceptive methods such as condoms.

Taking this medicine should not be interrupted suddenly unless the doctor speaks. Otherwise, as suddenly, the stop treatment is likely to return the symptoms. If this medicine is interrupted, it should normally be done gradually, under the supervision of a specialist.

 Attention should be taken in

mixed seizures, including absence crises

3 History of heart disease

History of liver disease

History of psychotic disease

High intra - eyepiece pressure (intra - eyepiece pressure) , eg. Glaucoma

of blood disorders that have been caused by any other historic drug

of the previous carbamazepine therapy that has been interrupted due to side effects or allergy

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.