Filastin 30 Pre-Filled Syringe

✔️ Filgrastim 300 mcg/0.5 ml

✔️ Dosage & Administration: Chemotherapy-Induced Neutropenia:

0.5 MU (5 mcg)/kg/day SC or IV, starting no sooner than 24 hours after chemotherapy. Continue until neutrophil recovery (typically up to 14 days; up to 38 days for AML).

✔️ Bone Marrow Transplantation:

1.0 MU (10 mcg)/kg/day IV infusion. Start at least 24 hours post-chemotherapy and post-transplant. Titrate according to neutrophil counts.

✔️ PBPC Mobilization for Autologous Transplant:

1.0 MU (10 mcg)/kg/day SC for 5–7 days. Begin at least 4 days before leukapheresis.

✔️ Severe Chronic Neutropenia:

Congenital: 0.6 MU (6 mcg)/kg twice daily SC

Cyclic/Idiopathic: 0.5 MU (5 mcg)/kg once daily SC
Titrate based on ANC and CBC monitoring.

✔️ Radiation Exposure (Hematopoietic Syndrome):

1.0 MU (10 mcg)/kg/day SC once daily.

✔️ HIV-Related Neutropenia:

Start with 0.1 MU (1 mcg)/kg/day SC; titrate up to 0.4 MU (4 mcg)/kg/day to maintain ANC > 2.0 × 10⁹/L.

✔️ Common Side Effects

Chemotherapy patients: fever, pain, rash, cough, shortness of breath

AML: rash, nasal bleeding, general pain

BMT recipients: skin rash

PBPC mobilization: bone pain, fever, headache

SCN patients: anemia, nosebleeds, diarrhea, numbness, hair thinning

✔️ Interaction

Interactions are not fully established. Use caution with drugs like lithium, which can also stimulate neutrophil production.

✔️ Contraindications

Hypersensitivity to Filgrastim or its components

Patients with Kostmann’s syndrome (severe congenital neutropenia.

✔️ Pregnancy & Lactation

Pregnancy Category C
Animal studies show potential risk; human data is lacking.

Unknown if excreted in human milk—use with caution during breastfeeding.

✔️ Precautions

Do not use within 24 hours before or after chemotherapy

Regular CBC and ANC monitoring is required to avoid complications from high neutrophil counts

Risk of tumor stimulation in malignancy not excluded

Avoid diluting to concentrations below 5 mcg/mL

Can be diluted in 5% dextrose if needed

✔️ Storage

Store in a refrigerator at 2°C–8°C. Protect from light. Do not freeze. Avoid shaking the vial or pre-filled syringe.