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Defrol 1000IU Tablet 10pcs
Defrol 1000 IU Tablet is used for the treatment and prevention of conditions related to Vitamin D deficiency, including:
- Osteoporosis
- Hypoparathyroidism
- Rickets
- Osteomalacia
- Vitamin D Deficiency
- Pseudohypoparathyroidism
- Familial Hypophosphatemia
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✅ Description:
✔️ Dosage:
Defrol can be taken with or without food. It may be administered orally or intramuscularly (IM) as prescribed by the healthcare provider.
Adult Dosage
- Nutritional Deficiency (Vitamin D3):
- 5-10 mcg (200-400 IU) per day orally.
- Osteoporosis Prophylaxis and Treatment (>50 years):
- 800-1000 IU (20-25 mcg) daily with calcium supplements.
- May also be given as an IM injection.
- Hypoparathyroidism:
- 50,000-200,000 IU (0.625-5 mg) orally once daily with calcium supplements, or via IM injection.
Child Dosage
- Nutritional Supplementation:
- 0-12 months: 400 IU (10 mcg) once daily.
- 1-18 years: 600 IU (15 mcg) once daily.
- Vitamin D-Resistant Rickets:
- 12,000-500,000 IU (0.3-12.5 mg) orally once daily.
- Familial Hypophosphatemia:
- 40,000-80,000 IU (1-2 mg) once daily with phosphate supplements.
- May be reduced after the growth phase is complete.
✔️ Generally well tolerated, but some side effects may include:
- Hypercalcaemia (excessive calcium) or calcium intoxication.
- Acute symptoms of hypercalcemia: Anorexia, headache, dry mouth, nausea, vomiting, abdominal pain, or constipation.
✔️ Colecalciferol should not be used in:
- Patients with hypercalcemia (high blood calcium levels).
- Those with known hypersensitivity to Colecalciferol or related medications.
- Vitamin D toxicity.
✔️ Mode of Action:
Colecalciferol is a fat-soluble sterol essential for calcium and phosphate homeostasis, as well as bone mineralization. It enhances calcium absorption from the gastrointestinal tract and stimulates bone formation, promoting overall bone health.
✔️ Interactions
- Increased risk of hypercalcaemia when used with thiazide diuretics, calcium, or phosphate.
- Antiepileptic medications (e.g., carbamazepine, phenobarbitone, phenytoin, primidone) may require higher doses of vitamin D.
- Rifampicin and isoniazid may reduce vitamin D efficacy.
- Corticosteroids may counteract Vitamin D effects.
- Digoxin or any cardiac glycosides may have interactions.
- Reduced absorption when taken with cholestyramine, colestipol, mineral oil, or orlistat
✔️ Use with caution in individuals with:
- High blood calcium or phosphorus levels.
- Heart problems.
- Kidney disease.
- Ensure adequate intake of calcium and magnesium alongside Vitamin D.
- Lactation: Vitamin D is distributed into breast milk; use cautiously during breastfeeding.
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