Flexilax 10mg 10pcs | ePharma
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Flexilax 10mg 10pcs

Generic: Baclofen

Type: Tablet

Generic Name: Baclofen 10mg 

Manufacturer/Distributor: Square Pharmaceuticals Ltd. 

Price: ৳ 92
MRP ৳ 100 8% off


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Brief Description

Indications of Flexilax 10

A muscle relaxant is Flexilax 10. It is used to treat muscle symptoms like rigidity, tension, and stiffness that can be brought on by a variety of diseases and injuries like cerebral palsy, multiple sclerosis, motor neuron disease, or head, brain, or spine trauma.

Pharmacology of Flexilax 10

In the spinal cord, baclofen reduces monosynaptic and polysynaptic reflexes by activating GABAB receptors that stop the release of glutamate and aspartate. By acting at intraspinal sites, it may also depress the CNS. Additionally, baclofen has antinociceptive properties.

Dosage & Administration

Adults and kids older than ten years old: Ideally, take 5 mg three times per day with or after food. The maximum daily dose is 100 mg.

Children younger than ten years of age: Treatment is typically started with 2.5 mg (2.5 ml) administered four times per day, and then increased as necessary. daily maintenance dose

  • 10-20 mg for 12 months to 2 years (10-20 ml)
  • 2 to 6 years: 20 to 30 mg (20-30 ml)
  • 6 to 10 years: 30 to 60 mg (30-60 ml)

Interaction of Flexilax 10

  • If Baclofen is combined with substances that affect the central nervous system, alcohol, or synthetic opiates, increased sedation may result. Additionally, there is a higher risk of respiratory depression.
  • Antihypertensive medication dosage needs to be adjusted because combined treatment with Baclofen and antihypertensives is likely to increase the fall in blood pressure.
  • The pharmacological effects of Baclofen may be amplified by the concurrent use of tricyclic antidepressants, leading to pronounced muscular hypotonia.
  • Numerous reports of mental confusion, hallucinations, headaches, nausea, and agitation have been made in Parkinson's disease patients taking Baclofen along with levodopa and carbidopa.
  • Combining Baclofen and MAO inhibitors may have stronger CNS depressant effects. One or both of the agents' dosages should be adjusted accordingly and caution is advised.
  • Given the potential for a synergistic effect, caution should be taken when giving Baclofen along with magnesium sulfate or other neuromuscular-blocking medications.

Contraindications

Baclofen is not recommended for hypersensitive people to any of the product's ingredients.

Side Effects of Flexilax 10

  • The most frequent side effects of Baclofen are brief drowsiness, daytime sedation, dizziness, weakness, and fatigue.
  • Ten percent of patients report having a headache, ten percent report having trouble sleeping, and ten percent report having nightmares.
  • Other symptoms include euphoria, excitement, depression, confusion, hallucinations, paraesthesia, nightmares, muscle pain, tinnitus, slurred speech, coordination disorder, tremor, rigidity, dystonia, ataxia, blurred vision, nystagmus, strabismus, miosis.
  • Cardiovascular: hypotension ( 10%), syncope, palpitations, and rare cases of dyspnea., Constipation (10%), nausea (about 10%), dry mouth, anorexia, taste disturbance, abdominal pain, vomiting, diarrhea, and a positive stool test for occult blood are all gastrointestinal symptoms.
  • Genitourinary: Enuresis, urinary retention, dysuria, impotence, inability to ejaculate, nocturia, haematuria, and urinary frequency (10%).
    Among the other symptoms are rashes, pruritus, ankle edema, excessive sweating, weight gain, nasal congestion, vision abnormalities, hepatic function issues, and paradoxically increased spasticity. It is possible to develop muscular hypotonia that makes it difficult to move or walk, but this is typically treated by adjusting the dose.

Pregnancy & Lactation

Baclofen is classified as a pregnancy category B3 because there is no evidence that it is safe to take while pregnant. Baclofen is able to pass through the placental barrier. Baclofen should only be given to pregnant women if the physician believes the potential benefits outweigh the risks. Baclofen is excreted in breast milk, but the amounts are so tiny that no adverse effects on the child are predicted, according to the data thus far.

Precautions & Warnings

  • Patients with impaired renal function or those undergoing chronic hemodialysis should receive lower doses (roughly 5 mg per day).
  • Patients with spasticity, as well as psychotic disorders, schizophrenia, depressive or manic disorders, or confusional states, should be carefully managed and under close observation, because these disorders may exacerbate one another.
  • Baclofen may be used in patients with epilepsy and muscle spasticity with the proper supervision and ongoing anticonvulsive therapy.
  • After stopping Baclofen therapy or with an overdose, there may be a lowering of the convulsion threshold, and seizures have been reported.
  • Patients who currently have or have had peptic ulcers, cerebrovascular diseases, or hepatic, renal, or respiratory failure should use baclofen with caution.
  • Particularly in patients with cardiopulmonary disease and weak respiratory muscles, careful monitoring of cardiovascular and respiratory function is crucial.
  • Neurogenic problems that affect bladder emptying may get better while taking Baclofen.
  • Acute urine retention, however, is possible in patients with preexisting sphincter hypertonia.
  • In these situations, baclofen should be used with caution.
    Patients who have had strokes have not significantly benefited from baclofen.
  • Additionally, these patients have demonstrated a low level of drug tolerance.
  • In order to make sure that no medication-induced changes in these underlying diseases have taken place, appropriate laboratory tests should be carried out on a regular basis in patients with hepatic diseases or diabetes mellitus.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.

Ratings & Reviews

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