Brezofil 200mg Tablet 1 Strip

✔️ Caution is advised in patients with:

Several factors may reduce the hepatic clearance of xanthine derivatives, increasing plasma drug levels. These include advanced age, congestive heart failure, COPD, severe liver disease, infections, and concurrent use of interacting drugs. In such cases, dose reduction and monitoring of blood drug levels are recommended.

• Cardiovascular disease or hypertension
• Severe hypoxemia or hyperthyroidism
• Chronic cor pulmonale or congestive heart failure
• Liver or renal impairment
• Peptic ulcer disease
• Elderly patients

In patients with congestive heart failure, drug clearance may be significantly delayed, leading to prolonged elevated plasma levels even after discontinuation. There is no evidence of drug dependence or addiction.

✔️ Dosage & Administration

Elderly:

200 mg tablet, two or three times daily

Adults:

400 mg tablet, two or three times daily, or as directed by the physician

Children:

Above 12 years: 10 ml syrup or 200 mg tablet, two or three times daily

6–12 years: 6–9 mg/kg body weight, twice daily

Example: For a child weighing 10 kg, 3 ml (60 mg) twice daily

If the total daily requirement is 400 mg, a Doxophylline sustained-release (SR) tablet may be administered once daily, preferably as prescribed by the physician.

✔️ Treatment with xanthine derivatives may cause:

• Gastrointestinal disturbances (nausea, vomiting, epigastric pain)
• Headache, irritability, insomnia
• Palpitations, tachycardia, extrasystoles
• Tachypnea

Rarely, hyperglycemia or albuminuria

In cases of overdose, severe cardiac arrhythmias and tonic-clonic seizures may occur and may represent early signs of toxicity. If adverse effects appear, treatment may need to be discontinued and restarted at a lower dose after symptoms resolve, based on physician discretion.

✔️ Caution

Brezofil should not be used concomitantly with other xanthine derivatives. Intake of caffeine-containing foods and beverages should be limited during therapy.

Caution is advised when administered with ephedrine or other sympathomimetic agents. Certain medications such as erythromycin, troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, propranolol, and influenza vaccine may reduce hepatic clearance of xanthines, leading to elevated plasma drug levels.

Conversely, phenytoin, other anticonvulsants, and cigarette smoking may increase drug clearance and reduce plasma half-life, which may necessitate dosage adjustment.

✔️ Brezofil is contraindicated in patients with:

• Known hypersensitivity to doxophylline or other xanthine derivatives
• Acute myocardial infarction
• Hypotension
• Lactation

✔️ Pregnancy & Lactation

Animal studies indicate that doxophylline does not adversely affect pre- or postnatal development. However, due to limited clinical data in pregnant women, use during pregnancy should be carefully considered based on the risk-benefit ratio.
The drug is contraindicated during lactation.

✔️ Storage:

Store in a dry place, protected from light and heat.
Keep out of reach of children.
Brezofil should be used only on the prescription of a specialist physician.