Clonazepam, the active ingredient in Pase, is a benzodiazepine with anticonvulsant, sedative, muscle-relaxing, and anxiolytic properties. Its primary action involves enhancing GABAergic neurotransmission at inhibitory synapses. By binding to GABA receptors, clonazepam increases the affinity for GABA, enhancing chloride ion flux and inhibitory effects on neurons.
Additionally, clonazepam affects serotonin pathways and suppresses various paroxysmal EEG activities, including those seen in absence seizures, slow spike waves, and other focal or generalized epileptic discharges. These properties make it effective in treating both generalized and focal epilepsies.
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Cilnidipine, a dihydropyridine calcium-channel blocker, acts by binding to L-type voltage-dependent calcium channels, reducing calcium ion (Ca²⁺) influx into vascular smooth muscle cells. This leads to muscle relaxation and vasodilation. Cilnidipine also inhibits Ca²⁺ influx via N-type calcium channels in sympathetic nerve membranes, reducing norepinephrine release and potentially preventing reflexive heart rate increases after blood pressure reduction.
Do not consume alcohol while taking Pase 0.5 as it may provoke seizures or fits and may worsen side effects possibly leading to severe sedation.
Pase 0.5 is generally not recommended for use in pregnant women unless considered necessary. Consult your doctor before taking it.
Pase 0.5 is generally not recommended for use in breastfeeding women as it may pass through the breast milk and may cause drowsiness and feeding difficulties. Consult your doctor before taking Pase 0.5.
Pase 0.5 may cause drowsiness or sleepiness which can affect your ability to drive and operate machines. Do not drive or operate any machines while taking Pase 0.5.
Pase 0.5 should be used with caution in patients with severe kidney disease. Consult your doctor before taking it.
Pase 0.5 is not recommended for use in patients with severe liver disease. It should be used with caution in patients with mild to moderate liver disease. Consult your doctor before taking it.
Symptoms: Drowsiness, ataxia, dysarthria, nystagmus, respiratory depression, hypotension, coma, or cardiac arrest (severe cases).
Treatment: Supportive measures, monitoring vitals, administering activated charcoal (if within 1-2 hours), and flumazenil (a benzodiazepine antagonist) under strict medical supervision.
Pase’s long-term effectiveness (beyond 9 weeks) has not been systematically studied in controlled trials. Physicians should periodically reassess its long-term usefulness for individual patients.
Take medication only as advised by a registered physician.
Adults (Seizures):
Adults (Panic Disorder):
Pediatric Patients (Seizures):
Pregnancy:
Lactation:
Store in a dry place, away from light and heat. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.