Tret 20mg Capsule

Uses of Tret 20mg Capsule

• Treatment of Acne

How does Tret 20mg Capsule work?

Tret 20mg Capsule treats acne by suppressing the activity of sebaceous glands (oil glands in the skin), and lowering oil (sebum) production in the skin. Tret 20mg Capsule also prevents keratinization (the formation of a horn-like feature by epithelial tissue), which may contribute to acne.

Side Effects of Tret 20mg Capsule

• Dry eyes, mouth, nose, or skin
• Chapped lips
• Vision or hearing problems
• Allergic reactions

Quick Suggestions:

• Take Tret 20mg Capsule with food: It is recommended to take the capsule with a meal to enhance absorption and minimize the risk of stomach upset.
• Avoid sunlight exposure: Tret 20mg Capsule can increase sensitivity to sunlight, making your skin more prone to sunburn. It is important to use protective measures such as applying sunscreen with a high SPF, wearing protective clothing, and avoiding prolonged sun exposure.
• Avoid face waxing and laser treatment: Tret 20mg Capsule can make your skin more fragile and sensitive. It is advised to avoid procedures such as facial waxing and laser treatment while using this medication to prevent skin damage.
• Manage dryness of mouth, lips, and eyes: Tret 20mg Capsule may cause dryness of the mouth, lips, and eyes. It is recommended to drink plenty of water, use moisturizers for the lips and skin, and consider using eye drops if needed. If the dryness becomes bothersome, inform your doctor.
• Avoid during pregnancy, planning pregnancy, and breastfeeding: Tret 20mg Capsule is contraindicated during pregnancy, as it can cause severe birth defects. It should also be avoided if you are planning a pregnancy or if you are breastfeeding. It is important to discuss reliable contraceptive methods with your doctor while using this medication.

Indication of Tret 20mg Capsule

Tret 20mg Capsule is used in adults and children (older than 12 years of age) to treat a severe form of acne that has not improved after other anti-acne treatments

Pharmacology

Isotretinoin is a synthetic retinoid that reduces sebaceous gland size and sebum production. It also regulates cell proliferation and differentiation.

Dosage & Administration of Tret 20mg Capsule

• Adult Dose: For the treatment of severe, recalcitrant nodular acne that has not responded to conventional therapy, including systemic antibiotics, the recommended adult dose is 0.5-1 mg/kg/day taken orally, divided into two doses per day. This treatment duration typically lasts for 15-20 weeks. In cases where the disease is very severe with scarring or primarily affects the trunk, the dose may be increased up to 2 mg/kg/day if tolerated. However, it's important to note that Tret 20mg Capsule is contraindicated in individuals with hepatic impairment.
• Child Dose: For children aged 12 years and above with severe, recalcitrant nodular acne unresponsive to conventional therapy, including systemic antibiotics, the recommended dose is 0.5-1 mg/kg/day taken orally, divided into two doses per day. This treatment duration typically lasts for 15-20 weeks. Similar to adults, if the disease is very severe with scarring or primarily affects the trunk, the dose may be increased up to 2 mg/kg/day if tolerated. The safety and efficacy of Tret 20mg Capsule have not been established in children below 12 years of age.
• Renal Dose: In individuals with severe renal impairment, it is recommended to reduce the initial dose (e.g., 10 mg daily) and then gradually increase it to 1 mg/kg as necessary. Adjustments in dosage should be made based on the individual's renal function.

It's important to follow the prescribed dosage and duration of treatment as advised by a healthcare professional. Individual dosing may vary, so it's crucial to consult a doctor for personalized advice and guidance, especially for individuals with hepatic or renal impairment.

Interaction

Before taking Tret 20mg Capsule, it is important to inform your doctor about any other medications or supplements you are currently taking. Here are some examples of medicines that should be disclosed:

• Vitamin A supplements: Taking Tret 20mg Capsule along with vitamin A supplements may increase the risk of vitamin A toxicity.
• Medicines used to treat bacterial infections: Certain antibiotics like minocycline and doxycycline may interact with the Tret 20mg Capsule, potentially increasing the risk of side effects.
• Phenytoin: This medication is used to treat seizures. Concurrent use with Tret 20mg Capsule may alter the blood levels of both drugs and require dosage adjustments.
• Medicines used to treat various inflammatory conditions: Corticosteroids such as betamethasone, prednisolone, and dexamethasone may interact with the Tret 20mg Capsule, potentially increasing the risk of side effects.
• Medicines used to prevent pregnancy: Hormonal contraceptives containing norethindrone and ethinyl estradiol may interact with Tret 20mg Capsule. Your doctor may recommend additional contraceptive methods or adjustments to your current contraception plan.
• St. John's wort: This herbal medicine used to treat mental disorders may interact with Tret 20mg Capsule, affecting its effectiveness. It is important to inform your doctor if you are using St. John's wort.
• Other medicines used to treat acne: Using Tret 20mg Capsule simultaneously with other acne treatments like salicylic acid and benzoyl peroxide may increase the risk of skin irritation and dryness.

In case of an overdose of Tret 20mg Capsule, it is crucial to seek immediate medical attention. Symptoms of an overdose may include severe headache, abdominal pain, nausea, dizziness, facial redness, vomiting, drowsiness, irritability, and itching.

Contraindications

If you are allergic to isotretinoin or other ingredients of Tret 20mg Capsule.

• If you are pregnant or breastfeeding.
• If you have high levels of lipids in the blood.
• It must not be given to children below 12 years of age.

Pregnancy & Lactation

Tret 20mg Capsule is not recommended for use in pregnant women and women planning a pregnancy. It is important to inform your doctor if you become pregnant during treatment with Tret 20mg Capsule. It is advised to avoid getting pregnant for at least one month after stopping the treatment, as some medication may still be present in the body. It is recommended to consult your doctor before taking Tret 20mg Capsule.

Contraception should be used one month prior to starting Tret 20mg Capsule, during the treatment period, and for one month after discontinuation. It is essential to discuss suitable contraceptive methods with your doctor to ensure effective protection against pregnancy.

Tret 20mg Capsule is not recommended for use in breastfeeding women, as the medication may pass through breast milk. It is important to consult your doctor before taking Tret 20mg Capsule if you are breastfeeding.

Always follow your doctor's instructions and discuss any concerns or questions you have regarding pregnancy, contraception, or breastfeeding with them. They will provide you with appropriate guidance based on your individual circumstances.

Precautions & Warnings

Here are some important points to consider before taking Tret 20mg Capsule:

• Preexisting or predisposition to hypertriglyceridemia: If you have conditions such as diabetes, obesity, or increased alcohol intake that may increase the risk of high triglyceride levels, it is important to monitor your triglyceride levels while taking Tret 20mg Capsule.
• Monitoring blood lipids and liver function: Regular monitoring of blood lipids (such as cholesterol) and liver function tests (LFTs) is recommended. This helps to assess the effects of the Tret 20mg Capsule on these parameters.
• Monitoring blood glucose: If you have known or suspected diabetes mellitus, it is important to monitor your blood glucose levels while taking Tret 20mg Capsule.
• Genetic predisposition for age-related osteoporosis: If you have a genetic predisposition for age-related osteoporosis or a history of childhood osteoporosis, osteomalacia, or other bone metabolism disorders, extra caution is needed while taking Tret 20mg Capsules. Regular monitoring and appropriate measures to maintain bone health may be necessary.
• Anorexia nervosa: Tret 20mg Capsule should be used with caution in individuals with a history of anorexia nervosa.
• History of psychiatric disorder: If you have a history of psychiatric disorders, it is important to inform your doctor before starting treatment with Tret 20mg Capsule. This medication may have an impact on mood and psychiatric symptoms.
• Impairment of night vision: Tret 20mg capsules may impair night vision, so it is important to be cautious while driving or operating machinery in low-light conditions.
• Avoid wax epilation and skin resurfacing procedures: To prevent skin irritation and increased sensitivity, it is recommended to avoid wax epilation and skin resurfacing procedures for at least 6 months after stopping Tret 20mg Capsule.
• Avoid prolonged exposure to UV light or sunlight: Tret 20mg Capsule can increase the sensitivity of your skin to sunlight. It is advisable to minimize exposure to UV light and sunlight and use protective measures such as sunscreen and protective clothing.
• Discontinue in case of certain adverse effects: If you experience hearing impairment, abdominal pain, rectal bleeding, severe diarrhea, or adverse ocular effects, discontinue the use of Tret 20mg Capsule and consult your doctor.
• Blood donation: During the course of therapy with Tret 20mg Capsule and for at least 1 month after discontinuation, you should not donate blood.
• Lactation: The distribution of Tret 20mg Capsule into breast milk is unknown. Therefore, it is not recommended for use in breastfeeding women.

Storage Conditions

Store in a cool & dry place. Protect from light.