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Siglimet 50/500mg Tablet 1 Strip
Siglimet is recommended as an adjunct to diet and exercise to enhance blood sugar control in adults with type 2 diabetes mellitus, especially when combination therapy with sitagliptin and metformin is appropriate.
Not suitable for patients with type 1 diabetes or diabetic ketoacidosis.
Safety has not been established in patients with a history of pancreatitis. It is unclear whether such patients are at higher risk of pancreatitis during treatment.
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✅ Description:
This combination tablet utilizes two complementary mechanisms to manage blood glucose:
- Sitagliptin (DPP-4 inhibitor): Slows the degradation of incretin hormones (GLP-1 and GIP), enhancing insulin secretion and reducing glucagon levels in a glucose-dependent manner, thereby improving glycemic control.
- Metformin (Biguanide): Lowers glucose production in the liver, reduces intestinal absorption of glucose, and enhances insulin sensitivity in peripheral tissues.
Together, they offer a dual approach to improving glycemic control.
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✔️ Dosage & Administration of Siglimet 50/500
Immediate-Release Tablet
- Dosed twice daily with meals.
- Initial dosage depends on the patient's existing therapy.
- Do not exceed 100 mg of sitagliptin and 2000 mg of metformin per day.
Gradual dose escalation is advised to minimize gastrointestinal side effects from metformin.
Extended-Release Tablet
- Taken once daily with the evening meal.
- Can be adjusted based on tolerance and effectiveness.
- Two extended-release tablets (e.g., 50/500 or 50/1000) should be taken together once daily.
Maintain the same total daily dose when switching between immediate and extended-release forms.
In Combination with Insulin or Sulfonylureas
May require dose adjustments to prevent hypoglycemia.
✔️ Side Effects of Siglimet 50/500
- Common (≥5%): Diarrhea, headache, upper respiratory infections, nasopharyngitis.
- Combination with sulfonylurea or insulin: Risk of hypoglycemia increases.
- Metformin-specific: Nausea, vomiting, flatulence, abdominal discomfort, fatigue.
✔️ Drug Interactions
- Cationic drugs (excreted via renal tubules): Use with caution.
- Phenprocoumon: Metformin may reduce its anticoagulant effect; monitor INR.
- Levothyroxine: Can reduce metformin’s effectiveness; monitor glucose levels when initiating or stopping thyroid hormone therapy.
✔️ Contraindications
Do not use in patients with:
- Renal impairment (e.g., serum creatinine ≥1.5 mg/dL for men, ≥1.4 mg/dL for women).
- Acute or chronic metabolic acidosis.
- Known hypersensitivity to sitagliptin or the combination tablet.
- Undergoing radiologic procedures with iodinated contrast (risk of acute kidney injury).
✔️ Use in Pregnancy & Lactation
- Pregnancy Category B: Use only if needed. No adequate studies in humans.
- Unknown if sitagliptin is excreted in breast milk. Use with caution during lactation.
✔️ Precautions & Warnings
- Lactic Acidosis: Rare but serious. Risk factors include renal impairment, liver disease, alcohol abuse, and acute illness.
- Pancreatitis: Discontinue if suspected.
- Renal Function: Assess before starting and at least annually.
- Vitamin B12 Deficiency: May occur with long-term metformin use.
- Hepatic Disease: Avoid use.
- Allergic Reactions: Rare but may include anaphylaxis, angioedema, and skin reactions such as Stevens-Johnson syndrome.
- May need temporary insulin substitution during periods of stress (fever, surgery, trauma, etc.).
- No proven benefit in reducing macrovascular complications.
✔️ Storage:
- Store below 25°C, away from moisture and light.
- Keep out of reach of children.
- Do not use beyond expiry date.
- Dispense only on prescription.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
