Secrin 2mg Tablet 10pcs

Uses of Secrin 2mg Tablet

• Type 2 Diabetes

How does Secrin 2mg Tablet work?

Secrin 2mg Tablet acts as an antidiabetic medication by increasing the release of insulin from the pancreas, thereby lowering blood glucose levels.

Side Effects of Secrin 2mg Tablet

Hypoglycemia, headache, nausea, dizziness. Rare: Allergic skin reactions, cholestasis, elevation of liver enzyme levels.

Quick Suggestions:

• Take shortly before or with the first main meal of the day, typically breakfast. Avoid skipping meals.
• Exercise regularly, follow a healthy diet, and take other prescribed diabetes medicines.
• Monitor blood sugar levels regularly.
• Be cautious while driving or operating machinery until the medication's effects are known.
• Secrin 2 can cause hypoglycemia when used with other antidiabetic medicines, alcohol, or if meals are delayed or skipped.
• Carry a source of glucose, like sugary food or fruit juice, to manage hypoglycemic symptoms.
• Regularly check liver function; inform your doctor of any symptoms like abdominal pain or jaundice.

Indications:

• Glimepiride is recommended as an adjunct to diet and exercise to lower blood glucose in patients with noninsulin-dependent (Type II) diabetes mellitus (NIDDM) when hyperglycemia cannot be controlled by diet and exercise alone.
• Glimepiride may be used concurrently with metformin when diet, exercise, and either Glimepiride or metformin alone do not result in adequate glycemic control.
• Glimepiride is also indicated for use in combination with insulin to lower blood glucose in patients whose hyperglycemia cannot be controlled by diet and exercise along with an oral hypoglycemic agent. Combined use of Glimepiride and insulin may increase the potential for hypoglycemia.

Pharmacology

Glimepiride is a sulfonylurea antidiabetic agent that reduces blood glucose concentration. Its primary mechanism of action involves stimulating the release of insulin from functional pancreatic beta cells. Glimepiride acts in concert with glucose by improving the sensitivity of beta cells to physiological glucose stimulation, resulting in insulin secretion. Additionally, extrapancreatic effects such as a reduction in basal hepatic glucose production, increased peripheral tissue sensitivity to insulin, and glucose uptake may also contribute to the action of Glimepiride. In non-fasting diabetic patients, the hypoglycemic activity of a single dose of Glimepiride persists for 24 hours.

Dosage & Administration:

Adult Dose:

• Initially, 1-2 mg daily, increased in increments of 1-2 mg at intervals of 1-2 weeks. Maintenance: 4 mg daily. Max: 6 mg daily. For the elderly, initially 1 mg once daily. Severe hepatic impairment is contraindicated.

Child Dose:

• Safety and efficacy not established.

Renal Dose:

• Renal impairment: 1 mg PO qDay; titrate dose based on fasting blood glucose levels. Severe renal impairment is contraindicated.

Administration:

• To be taken with food. Should be taken just before or during the first main meal of the day. Avoid skipping meals.

Interaction

Interactions that may potentiate the hypoglycemic activity of Glimepiride include ACE inhibitors, anabolic steroids, azapropazone, chloramphenicol, coumarin derivatives, fluconazole, MAO inhibitors, probenecid, quinolones, salicylates, sulfonamide antibiotics, and more. Drugs that may diminish the hypoglycemic activity include barbiturates, calcium channel blockers, corticosteroids, diazoxide, diuretics, glucagon, isoniazid, nicotinic acid, phenothiazines, rifampicin, sympathomimetic agents, thyroid hormones, and others.

Contraindications

Glimepiride is not suitable for the treatment of insulin-dependent (Type I) diabetes mellitus, diabetic ketoacidosis, or diabetic coma. It should not be used in patients allergic to Glimepiride, other sulfonylureas, other sulfonamides, severe hepatic dysfunction, severe impairment of renal function, or dialysis patients.

Pregnancy & Lactation

Glimepiride is contraindicated during pregnancy, and a transition to insulin is necessary. Breastfeeding women should not take Glimepiride as it may harm the baby. Transitioning or complete cessation of breastfeeding is necessary.

Precaution & Warnings:

Increased risk of CV mortality, monitor blood glucose concentration. Caution in the elderly, hepatic and renal impairment, and SIADH in patients with CHF or hepatic cirrhosis. Pregnancy, lactation.

Storage Conditions

Store below 30°C temperature, protected from light and moisture. Keep out of the reach of children.