Linatab M 2.5/500 Tablet | Type 2 Diabetes | medicine | ePharma
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Linatab M 2.5/500 Tablet

Generic: Linagliptin + metformin hydrochloride

Type: Capsule

Pack Size: 10 Pcs

Linagliptin 2.50mg + Metformin 500mg-

  • Stimulates Insulin Production: This medication helps stimulate the pancreas to produce more insulin, a hormone that regulates blood sugar levels.
  • Enhances Insulin Utilization: It improves the body's utilization of insulin, making it more effective in reducing blood sugar levels.
  • Lowers Liver Sugar Production: Linatab M 2.5/500 Tablet reduces the excess sugar produced by the liver, preventing unnecessary spikes in blood sugar levels, especially after meals.

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Linatab M 2.5/500 Tablet is a combination medication used to manage type 2 diabetes. 

  • LINAGLIPTIN: A dipeptidyl peptidase-4 (DPP-4) inhibitor that helps the body produce more insulin when needed and reduces excessive sugar production by the liver.
  • METFORMIN: A biguanide that lowers glucose production in the liver, delays glucose absorption from the intestines, and enhances the body's sensitivity to insulin.
  • Combining these two medications helps regulate blood glucose levels in individuals with type 2 diabetes.
  • LINAGLIPTIN prevents the breakdown of incretin hormones, which stimulate insulin release when blood sugar is elevated and inhibit glucagon release when it's not needed.
  • METFORMIN reduces glucose production, slows absorption, and increases insulin sensitivity, preventing post-meal spikes in blood sugar.
  • Take LINAGLIPTIN+METFORMIN with food to avoid stomach upset.
  • Consistently take it at the same time each day for optimal results.
  • The dosage may be adjusted by your doctor based on your condition.
  • Continue taking LINAGLIPTIN+METFORMIN as prescribed, even if you feel better, to maintain stable blood sugar levels.
  • Abruptly stopping the medication can lead to increased blood sugar levels and potential complications.
  • Do not use this medication if you have type 1 diabetes, or severe kidney or liver disease.
  • Inform your doctor if you have heart disease, plan to become pregnant, or are breastfeeding.

Safety Advices


Avoid consumption of alcohol while taking Linatab M 2.5/500 Tablet  as it may increase the risk of unwanted side effects.


It is not known whether the use of Linatab M 2.5/500 Tablet could affect the unborn baby. Therefore, it should not be used during pregnancy unless recommended by your doctor.


It is not known whether the use of Linatab M 2.5/500 Tablet could pass through the breast milk. Therefore, it should be used in breastfeeding only if considered necessary by the physician


Linatab M 2.5/500 Tablet has no influence on your ability to drive or handle heavy tools or machines. However, do not drive or operate any machines if your ability is affected by LINAPIL M 2.5/500 TABLET.


Linatab M 2.5/500 Tablet is not recommended for use in patients with severely reduced kidney functions. Therefore, consult your doctor before taking it.


Linatab M 2.5/500 Tablet is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gallstones. Therefore, consult your doctor before taking it.

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Uses of Linatab M 2.5/500 Tablet
  • Treats Type II diabetes mellitus in adults
How does Linatab M 2.5/500 Tablet work?

LINAPIL M 2.5/500 TABLET is an antidiabetic medicine. It contains two medicines namely metformin and Linagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduce its absorption in the body.

Linagliptin controls blood sugar levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that reduces insulin secretion in the body. Collectively, Linatab M 2.5/500 Tablet controls blood sugar levels and improves glycemic control in patients with type II diabetes.

Side Effects of Linatab M 2.5/500 Tablet
  • Runny nose
  • Sore throat
  • Diarrhea
  • Nausea
  • Vomiting
  • Upper lung infection
  • Low Blood Sugar
  • Gas
  • Stomach upset
  • Indigestion,
  • General weakness
  • Headache
Quick Suggestions:
  • You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.
  • Linatab M 2.5/500 Tablet should be taken with food to lower the chances of having an upset stomach.
  • Take it in addition to regular exercise and a healthy diet to lower the levels of blood sugar.
  • Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines.
  • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol, or by delaying/skipping a meal. Carry a sugar source with you for immediate relief.
  • Monitor your blood sugar level regularly while you are taking this medicine.
  • Inform your doctor about your diabetes treatment if you are due to have any surgery under a general anesthetic.
  • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, or stomach pain as Linatab M 2.5/500 Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Linagliptin is used to help people with type 2 diabetes regulate their blood sugar levels. DPP-4 (dipeptidyl peptidase-4) is an enzyme that degrades the incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucagon-like peptide-1). Linagliptin is an inhibitor of DPP-4 (dipeptidyl peptidase-4) (glucose-dependent insulinotropic polypeptide). Linagliptin stimulates the release of insulin from pancreatic beta () cells in a glucose-dependent manner while reducing the production of glucagon from pancreatic alpha () cells in the blood, increasing the concentrations of active incretin hormones.

Metformin Hydrochloride is an antihyperglycemic medication of the biguanide class that is used to treat type 2 diabetes. Both baseline and postprandial plasma glucose levels are reduced. It has a different mode of action than sulfonylureas and does not cause hypoglycemia. Metformin Hydrochloride reduces hepatic glucose synthesis, intestinal glucose absorption, and insulin sensitivity by increasing peripheral glucose uptake and utilization.

Dosage & Administration of Linatab M 2.5/500 Tablet

The dosing instructions for Linagliptin & Metformin immediate-release and extended-release tablets are as follows:

Linagliptin & Metformin Immediate-Release Tablet:

  • Dosage should be individualized based on effectiveness and tolerability.
  • The maximum recommended dose is 2.5 mg of Linagliptin and 1000 mg of Metformin Hydrochloride twice daily with meals.
  • For patients not currently treated with Metformin Hydrochloride, initiate treatment with 2.5 mg of Linagliptin and 500 mg of Metformin Hydrochloride twice daily.
  • For patients already treated with Metformin Hydrochloride, start with 2.5 mg of Linagliptin and the current dose of Metformin Hydrochloride twice daily.
  • If patients are already treated with Linagliptin and Metformin Hydrochloride as individual components, they may be switched to this combination with the same doses of each component.

Linagliptin & Metformin Extended-Release Tablet:

  • Dosage should also be individualized based on effectiveness and tolerability, without exceeding the maximum recommended total daily dose of Linagliptin 5 mg and Metformin Hydrochloride 2000 mg.
  • This combination should be taken once daily with a meal.
  • For patients not currently treated with Metformin, initiate treatment with 5 mg of Linagliptin/1000 mg of Metformin Hydrochloride extended-release once daily with a meal.
  • For patients already treated with Metformin, start this combination with a total daily dose of 5 mg of Linagliptin and a similar total daily dose of Metformin once daily with a meal.
  • For patients already treated with Linagliptin and metformin immediate-release tablets, switch to the extended-release tablet containing 5 mg of Linagliptin total daily dose and a similar total daily dose of Metformin once daily with a meal.
  • Follow the specific dosing instructions based on the Linagliptin and Metformin Hydrochloride doses required.

Please note that the extended-release tablet is taken once daily, while the immediate-release tablet may be taken twice daily, as prescribed by your healthcare provider. Always follow your doctor's instructions for the correct dosage and timing of these medications.


Linatab M 2.5/500 Tablet is a medication that can interact with various drugs, foods, and medical conditions. Here's a summary of these interactions:

Drug-Drug Interactions: Linatab M 2.5/500 Tablet can interact with several other medications, including:

  • Anti-depressants (bupropion)
  • Painkillers (aspirin)
  • Antibiotics (cephalexin, ciprofloxacin)
  • Anti-acidity drugs (cimetidine)
  • Heart condition drugs (ranolazine, digoxin)
  • Anti-HIV drugs (dolutegravir)
  • Anti-hypertensives (amlodipine, verapamil)
  • Anti-epileptic drugs (topiramate, lamotrigine)
  • Oral contraceptives

It's important to inform your healthcare provider about all the medications you are taking to avoid potential interactions.

Drug-Food Interactions: Excessive consumption of alcoholic beverages while taking Linatab M 2.5/500 Tablet can increase the risk of a serious condition called Lactic Acidosis. It is advisable to avoid excessive alcohol intake while on this medication.

Drug-Disease Interactions: Individuals with certain medical conditions should exercise caution when taking Linatab M 2.5/500 Tablets. These conditions include:

  • Heart diseases such as congestive heart failure and myocardial infarction.
  • Vitamin B12 deficiency.
  • Alcoholism.

If you have any of these medical conditions, it's essential to discuss the use of this medication with your doctor, as special monitoring or dosage adjustments may be necessary to ensure your safety and effectiveness of treatment.


Metformin Hydrochloride is primarily eliminated by the kidneys, and although Linagliptin has low renal excretion, severe renal impairment can increase the risk of Metformin Hydrochloride accumulation and lactic acidosis. Therefore, individuals with renal impairment should avoid this combination medications. Other contraindications include acute or chronic metabolic acidosis (such as diabetic ketoacidosis) and hypersensitivity to either Linagliptin or Metformin Hydrochloride. It's crucial for individuals with these conditions to refrain from using this medication.

Pregnancy & Lactation

Because there are no sufficient and well-controlled trials in pregnant women with this combination or its separate components, it should only be taken if obviously needed during pregnancy. When given to a nursing woman, extreme caution should be exercised.

Precautions & Warnings

Linatab M 2.5/500 Tablet comes with several important precautions and considerations:

  • Type 1 Diabetes and Diabetic Ketoacidosis: This medication should not be used in patients with type 1 diabetes or those experiencing diabetic ketoacidosis.
  • Lactic Acidosis Risk: There is a rare but serious risk of developing lactic acidosis while taking Linatab M 2.5/500 Tablet. This condition involves an accumulation of too much lactic acid in the blood, which can harm the liver and kidneys responsible for removing excess lactic acid. Inform your doctor if you experience any symptoms of lactic acidosis.
  • Pre-existing Conditions: Before starting Linatab M 2.5/500 Tablet, inform your doctor if you have a history of pancreatitis (inflammation of the pancreas), kidney disease, or low vitamin B12 levels.
  • Hypoglycemia Risk: When Linatab M 2.5/500 Tablet is used with insulin, it can significantly lower blood sugar levels, potentially leading to hypoglycemia (dangerously low blood sugar). Your doctor may need to adjust your insulin or Linapil-M 2.5/500mg Tablet 10's dosage to prevent this condition.
  • Thyroid Function: Prolonged use of Linatab M 2.5/500 Tablet may lower thyroid-stimulating hormone (TSH) levels. Regular TSH check-ups are recommended.
  • Skin Reaction: In rare cases, individuals may develop a serious skin reaction called bullous pemphigoid while using Linatab M 2.5/500 Tablet. Immediate medical attention is required if this occurs.
  • Diagnostic Tests: Inform your doctor if you are scheduled for a diagnostic test involving the injection of dye or X-ray contrast agents. Linatab M 2.5/500 Tablet may need to be temporarily discontinued before such procedures.
Storage Conditions

Keep away from light and heat in a dry area. Keep out of children's reach.

Frequently Asked Questions (FAQ)

The use of Linatab M 2.5/500 Tablet should be avoided in patients with known allergy to any of the components of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis or diabetic ketoacidosis. Therefore, consult your doctor before using Metformin+Linagliptin.

The use of Linatab M 2.5/500 Tablet does not usually cause hypoglycemia (low blood sugar level) on its own. But, it could occur if there is insufficient supplementation of calories while taking this medicine. Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. The symptoms are more likely to be noticed if you miss or delay your food, drink alcohol, over-exercise or take any other antidiabetic medicine along with it. Hence, regular monitoring of blood sugar level is important. It is recommended to always carry glucose tablets, honey or fruit juice with you.


Linatab M 2.5/500 Tablet contains Linagliptin (DPP4 inhibitors) and Metformin (Biguanide). Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that blocks the action of DPP-4, an enzyme that destroys the hormone incretin that helps the body produce more insulin only when required. It also reduces the amount of sugar produced by the liver when not needed. Metformin functions by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.
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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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