Monas 4mg Tablet

Uses of Monas 4mg Tablet

• Asthma
• Seasonal Allergies

How does Monas 4mg Tablet work?

Monas 4mg Tablet containing montelukast works by opposing the actions of Leukotrienes. Leukotrienes cause narrowing and swelling of airways in the lungs and also cause allergy symptoms. By blocking leukotrienes, Montelukast improves asthma symptoms, helps control asthma, and improves seasonal allergy symptoms.

Side effects of Monas 4mg Tablet

• Headache
• Stomach pain
• Body aches or Pain
• Pus in urine
• Agitation and anxiety
• Skin rash
• Heartburn
• Blurred vision
• Infection of the airways
• Swelling of face, lips, eyelids, tongue, hands and feet
• Nausea or Vomiting
• Diarrhea
• Fever

Quick Suggestions:

• Monas 4mg Tablet is prescribed for asthma prevention and the treatment of allergy symptoms like sneezing and runny nose.
• It is generally safe with minimal side effects.
• Take it 2 hours before exercising if you have exercise-induced asthma.
• It does not provide immediate relief during sudden breathing problems. For acute symptoms, use a rescue inhaler as prescribed.
• Do not stop using Monas 4mg Tablet without consulting your doctor, even if you feel better.
• If you have phenylketonuria, be aware that chewable tablets may contain aspartame, which is not recommended in this condition
• Anti-inflammatory compounds in ginger can help relax airway membranes, potentially reducing coughing.
• Stress can weaken the immune system, increasing the risk of illness. Managing stress through regular exercise, meditation, deep breathing, and relaxation techniques can help maintain a healthy immune system.
• Aim to get 7-9 hours of sleep each night to support overall health and immune function.
• Minimize contact with known allergens such as pollen and dust. Identify any food items that may cause allergies for you and avoid them.
• Personal hygiene and cleanliness: Maintain good personal hygiene practices and keep your surroundings clean to reduce the risk of respiratory infections.
• Adequate hydration is important for respiratory health. Drinking liquids at room temperature can help alleviate cough, runny nose, and sneezing.

Indication

Monas contains Montelukast, which is classified as a Leukotriene Receptor Antagonist. It is prescribed to adults and adolescents (aged 15 years or older) for the treatment and prevention of symptoms associated with chronic asthma and seasonal allergic rhinitis. It can also be used to prevent exercise-induced bronchospasm.

Pharmacology

Montelukast is a medication that works by inhibiting the cysteinyl leukotriene receptor, specifically the CysLT1 receptor. It is a selective and orally active leukotriene receptor antagonist. Leukotrienes are inflammatory mediators produced from the metabolism of arachidonic acid. Among the leukotrienes, cysteinyl leukotrienes (LTC4, LTD4, LTE4) play a significant role in the pathophysiology of asthma and allergic rhinitis. These cysteinyl leukotrienes are secreted by various cells, including mast cells and eosinophils. The binding of cysteinyl leukotrienes to their receptors, particularly the CysLT1 receptor, triggers a cascade of events that contribute to the signs and symptoms of asthma and allergic rhinitis. These events include airway edema (swelling), smooth muscle contraction, and altered cellular activity associated with the inflammatory process. By blocking the CysLT1 receptor, montelukast helps to reduce the effects of cysteinyl leukotrienes and their contribution to airway inflammation, smooth muscle constriction, and other cellular changes associated with asthma and allergic rhinitis. This, in turn, helps to alleviate the symptoms of these conditions.

Dosage & Administration of Monas 4mg Tablet

Adult Dose:

• Chronic asthma: 10 mg once daily in the evening (film-coated tablet)
• Allergic rhinitis: 10 mg once daily
• Prophylaxis of exercise-induced asthma: 10 mg at least 2 hours prior to exercise; do not take additional doses within 24 hours

Child Dose:

• Asthma Prophylaxis and maintenance treatment:
  • <12 months: Safety and efficacy not established
  • 12-24 months: 4 mg (granules) once daily in the evening
  • 2-6 years: 4 mg (chewable tablet or granules) once daily in the evening
  • 6-15 years: 5 mg (chewable tablet) once daily in the evening

15 years: 10 mg (conventional tablet) once daily in the evening

• Exercise-Induced Bronchospasm Prophylaxis:
  • 6-15 years: 5 mg (chewable tablet) 2 hours before exercise; do not take additional dose within 24 hours

15 years: 10 mg 2 hours before exercise; do not take additional dose within 24 hours

• If taking the drug for another indication, do not take an additional dose to prevent Exercise-Induced Bronchospasm (EIB)
• Perennial Allergic Rhinitis:
  • <6 months: Safety and efficacy not established
  • 6-24 months: 4 mg (granules) once daily
  • 2-6 years: 4 mg (chewable tablet or granules) once daily
  • 6-15 years: 5 mg (chewable tablet) once daily

15 years: 10 mg (conventional tablet) once daily

• Seasonal Allergic Rhinitis:
  • <2 years: Safety and efficacy not established
  • 2-6 years: 5 mg (chewable tablet) or 4 mg (granules) once daily
  • 6-15 years: 5 mg (chewable tablet) once daily

15 years: 10 mg (conventional tablet) once daily

Renal Dose:

• No dosage adjustment is needed for renal impairment.

Please note that this information is a summary and should be used as a reference. It is important to follow the specific dosing instructions provided by your healthcare professional for your condition.

Interaction

Montelukast (Monas) is primarily metabolized by the liver through cytochrome P450 enzymes. Co-administration with potent inducers of cytochrome P450 isoenzymes, such as phenobarbital, phenytoin, and rifampicin, may result in increased metabolism of montelukast. This increased metabolism can lead to decreased plasma concentrations of montelukast, potentially reducing its effectiveness.

When montelukast is used concomitantly with these potent inducers, close monitoring of the therapeutic response to montelukast is recommended. It may be necessary to adjust the dosage of montelukast or consider alternative treatment options if the therapeutic response is diminished. It is important to consult with a healthcare professional who can assess the specific situation and provide appropriate guidance.

Contraindications

Hypersensitivity.

Pregnancy & Lactation

The use of Montelukast in pregnant women has not been extensively studied in well-controlled trials. Therefore, its use during pregnancy should only be considered if absolutely necessary and the potential benefits outweigh the potential risks.

Montelukast is known to be excreted in breast milk, and caution should be exercised when administering it to nursing women. It is important to monitor and observe for any potential adverse effects in the infant when a nursing woman is taking montelukast.

Precautions & Warnings

• Montelukast is not intended for the relief of acute bronchospasm. It is not a rescue medication for sudden asthma symptoms but is used for long-term management and prevention of asthma symptoms.
• It should not be used as monotherapy for the prevention of exercise-induced bronchospasm. Additional therapies may be required for exercise-induced asthma.
• Patients who experience asthma triggered by aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) should continue to avoid these medications while using montelukast.
• Montelukast should not be abruptly substituted for oral or inhaled corticosteroids, which are commonly used for asthma management. The discontinuation or change of corticosteroid therapy should be done under the guidance of a healthcare professional.
• It is important to be alert for any signs or symptoms of Churg-Strauss syndrome, a rare condition characterized by blood vessel inflammation. If any suspicious symptoms arise, medical attention should be sought promptly.
• The use of montelukast during pregnancy and lactation should be approached with caution. The excretion of the drug in breast milk is unknown, so it is important to consult a healthcare professional to assess the potential risks and benefits.

Storage Conditions

• Keep Montelukast Tablet out of reach of children
• Store at room temperature