Maxpro 40mg Tablet 10pcs

Uses of Maxpro 40mg Tablet

Treatment of -

• Gastroesophageal reflux disease (Acid reflux)
• Peptic ulcer disease

How does Maxpro 40mg Tablet work?

Maxpro 40mg Tablet belongs to a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of enzymes in the stomach cell. It hence reduces gastric acidity by blocking the final step in acid production and helps in the relief of acid-related indigestion and heartburn.

Side Effects of Maxpro 40mg Tablet

• Headache
• Diarrhea
• Stomach pain
• Constipation
• Flatulence
• Nausea and vomiting
• Benign polyps in the stomach
• Swelling of the feet and ankles
• Troubled sleep
• Dizziness
• Tingling sensations
• Sleepiness
• Dry mouth
• Skin rash, hives, and itching
• Fracture of joints (such as hip, wrist, or spine)

Quick Suggestions:

• It is recommended to use this medicine in the prescribed manner. However, anti-reflux medicines should preferably be taken in the morning on an empty stomach or with food for optimum effectiveness.
• You can make certain lifestyle modifications like preventing excess intake of foods that cause acidity, like carbonated drinks and oily/fried food, regular exercise, and maintaining a healthy weight.
• It is also advised to limit alcohol intake and quit smoking for better treatment of your acidity.
• It is advised to reduce stress and get good sleep each night.
• Inform your doctor if you are using this medicine as a continuous treatment of acidity for more than 4 weeks or if the symptoms are persistent even after taking the medicine.
• This medicine can hamper the actions of other medicines taken simultaneously. Inform your doctor if you are using any other medicines.

Indication of Maxpro 40mg Tablet

Maxpro 40mg Tablet is indicated:

• Treatment of Gastroesophageal Reflux Disease (GERD)
• Healing of erosive esophagitis
• Maintenance of healing of erosive esophagitis
• Symptomatic Gastroesophageal Reflux Disease (GERD)
• Reduction of NSAID-associated gastric ulcer
• Pylori eradication (Triple therapy)
• Zollinger-Ellison syndrome

Pharmacology

The H+/K+ ATPase in the gastric parietal cell is inhibited by the proton pump inhibitor esomeprazole, which reduces the amount of stomach acid produced. Esomeprazole (omeprazole's S-isomer), the first proton pump inhibitor with a single optical isomer, offers better acid control than racemic proton pump inhibitors.

Dosage & Administration of Maxpro 40mg Tablet

Adult Dose:

1. GERD Without Erosive Esophagitis: 20 mg orally once a day for 4 weeks. Consider an additional 4 weeks of treatment if symptoms do not completely resolve in the first 4 weeks.
2. GERD With Erosive Esophagitis: 20-40 mg orally once a day for 4-8 weeks. If oral therapy is inappropriate or not possible, 20-40 mg intravenously once a day for up to 10 days. Switch to oral administration once the patient is able to swallow. The maintenance dose is 20 mg orally once a day for up to 6 months.
3. Risk Reduction of NSAID-Associated Gastric Ulcer: 20-40 mg orally once a day for up to 6 months.
4. NSAID-Induced Gastric Ulcer: 20 mg orally once a day for 4-8 weeks.
5. Zollinger-Ellison Syndrome: Initial dose of 80 mg orally divided every 12 hours, adjust the regimen based on efficacy. The maximum dose is up to 240 mg orally once a day or 120 mg orally every 12 hours.

Child Dose: The dosing for children varies based on the condition and age. Here are some examples:

1. GERD Without Erosive Esophagitis:
   • 1-12 years: 10-20 mg orally once a day for up to 8 weeks.

12 years: 20-40 mg orally once a day for up to 8 weeks.

1. GERD With Erosive Esophagitis (Healing):
   • 1 month to 1 year:
     • <3.5 kg: 2.5 mg orally once a day for up to 6 weeks.

3.5-7.5 kg: 5 mg orally once a day for up to 6 weeks.

7.5 kg: 10 mg orally once a day for up to 6 weeks.

• 1-12 years:
  • <20 kg: 10 mg orally once a day for 8 weeks.

20 kg: 10-20 mg orally once a day for 8 weeks.

12 years: 20-40 mg orally once a day for 4-8 weeks. Maintenance dose is 20 mg orally once a day for up to 6 months.

Renal Dose: No dosage adjustment is needed for patients with renal impairment.

It's important to note that these dosages are general guidelines, and individual patients may require different doses based on their specific condition and response to treatment. Always follow the instructions provided by your healthcare provider and consult them for personalized advice regarding your medication regimen.

Interaction

• Digoxin: Esomeprazole may increase the risk of digoxin-induced cardiotoxic effects.
• Diuretics: There is an increased risk of hypomagnesemia (low magnesium levels) when Esomeprazole is used with diuretics.
• Warfarin: Esomeprazole may increase the International Normalized Ratio (INR) and prothrombin time when used concomitantly with warfarin, which may increase the risk of bleeding.
• Tacrolimus, saquinavir, methotrexate: Esomeprazole may increase the serum concentration of these drugs, potentially leading to an increased risk of adverse effects.
• Drugs metabolized by CYP2C19 (e.g., diazepam): Esomeprazole may interfere with the elimination of drugs metabolized by the CYP2C19 enzyme, such as diazepam.
• Ketoconazole, erlotinib, Fe salts: Esomeprazole may decrease the bioavailability (absorption) of these drugs, potentially reducing their effectiveness.
• Rilpivirine, atazanavir, nelfinavir: Esomeprazole may decrease the serum concentration and pharmacological effects of these drugs.
• Clopidogrel: Esomeprazole may decrease the antiplatelet effects of clopidogrel, which may impact its ability to prevent blood clotting.

Contraindications

Esomeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted Benzimidazoles.

Pregnancy & Lactation

US FDA pregnancy category of Esomeprazole is C. So, Esomeprazole should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus

Precautions & Warnings

• Pediatric use: The safety and efficacy of Esomeprazole in pediatric patients have not been established. It should be used with caution in children.
• Pregnancy and lactation: The use of Esomeprazole during pregnancy and lactation should be evaluated carefully. Limited data suggest that omeprazole (the racemic mixture including Esomeprazole) may be present in human milk. The potential benefits of breastfeeding should be considered along with the mother's clinical need for Esomeprazole.
• Malignancy and hepatic impairment: Esomeprazole should be used with caution in patients with malignancy or hepatic impairment. Close monitoring and appropriate dose adjustments may be necessary.
• Increased risk of certain infections: Esomeprazole may increase the risk of developing certain infections, such as community-acquired pneumonia. Patients should be monitored for signs and symptoms of infection during treatment.
• Severe liver impairment: In patients with severe liver impairment, a dose of 20 mg should not be exceeded. Dose adjustment may be necessary for these patients.
• Excluding malignancy: Before initiating treatment for dyspepsia or gastric ulcer, it is important to exclude the possibility of malignancy. Proper evaluation and diagnosis should be performed.
• Combination with antibiotics: When using Esomeprazole in combination with antibiotics, it is important to refer to the prescribing information of the respective antibiotics for the proper use and potential interactions.

Storage Conditions

Store these tablets at room temperature. Store it in the original packaging to protect it from moisture. Please keep it away from children and pets.