Neugalin 50mg Capsule

Uses of Neugalin 50mg Capsule

• Treatment of Neuropathic pain
• Treatment of Epilepsy/Seizures
• Treatment of Fibromyalgia

How does Neugalin 50mg Capsule work?

Relieves pain by reducing the release of pain signal transmitting chemicals in the brain.

Side Effects of Neugalin 50mg Capsule

• Dry mouth, swelling in arms or feet, weight gain, weakness, confusion, fatigue.

Quick Suggestions:

• Pregabalin may be taken with or without food as prescribed by your doctor.
• Do not crush or chew the tablet or capsule.
• Take this medicine for the recommended duration.
• Avoid taking this medicine in larger or smaller quantities than recommended.
• Take this medicine at the same time every day for the ease of remembering.
• Inform your doctor if the symptoms do not improve or if you experience any unwanted effects that persist or worsen.

Indication

• Management of neuropathic pain associated with diabetic peripheral neuropathy
• Management of post-herpetic neuralgia
• Adjunctive therapy for adult patients with partial-onset seizures
• Management of fibromyalgia
• Neuropathic pain associated with spinal cord injury

Pharmacology

Pregabalin acts as a derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), but it doesn't directly bind to GABAA, GABAB, or benzodiazepine receptors. Instead, it exhibits a high affinity for the alpha-2-delta subunit, which is an auxiliary component of voltage-gated calcium channels in tissues of the central nervous system. The oral bioavailability of Pregabalin exceeds 90%, and its elimination from the systemic circulation primarily occurs through renal excretion as an unchanged drug. The half-life of Pregabalin is approximately 6.3 hours in individuals with normal renal function.

Dosage & Administration of Neugalin 50mg Capsule

Adult Dose:

Oral Neuropathic Pain, Postherpetic Neuralgia:

• Initial: 150 mg/day; may increase to 300 mg/day after 3-7 days.
• Max: 600 mg/day after a 7-day interval.
• All doses are administered in 2 or 3 divided doses.

Diabetic Peripheral Neuropathic Pain:

• Initial: 50 mg PO q8hr
• Maintenance: May increase to 100 mg PO q8hr within 1 week, not to exceed 300 mg/day

Adjunct in Partial Seizures:

• Adult: Initially, 150 mg/day; may increase to 300 mg/day after a week.
• Max: 600 mg/day.
• All doses are given in 2 or 3 divided doses.

Fibromyalgia:

• Initial: 150 mg/day; may increase to 300 mg/day after a week.
• Max: 450 mg/day if needed.
• All doses are administered in 2 or 3 divided doses.

Child Dose:

Safety and efficacy not established.

Renal Dose:

Renal Impairment: Haemodialysis:

• 25-100 mg immediately after each 4-hour hemodialysis session.

CrCl (ml/min) Dosage Recommendation:

• 30 to <60: 75 mg/day. Max: 300 mg/day. All doses are given in 2 or 3 divided doses.
• 15 to <30: Initially, 25-50 mg/day. Max: 150 mg/day. All doses are given as a single dose or in 2 divided doses.
• <15: Initially, 25 mg/day. Max: 75 mg/day. All doses are given as a single dose.

Interaction

Before taking Neugalin 50mg Capsule, inform your doctor if you are taking any of the following medicines such as:

• Oxycodone (used as a pain killer)
• Lorazepam (used for reducing anxiety)
• Oral contraceptives (birth control pills) Ex. ethinyl estradiol

Contraindications

• Allergy to pregabalin.
• Inform your doctor about kidney or heart problems.
• Not recommended for children below 18 years.

Pregnancy & Lactation

• Pregnancy category C; benefits should outweigh risks
• Use in nursing mothers only if benefits clearly outweigh risks

Precautions & Warnings

• May cause drowsiness or dizziness; avoid driving or operating machinery.
• Consult your doctor if side effects persist or become severe.
• Follow the prescribed dosage and duration; do not discontinue without consulting your doctor.
• Injection administered by healthcare professionals in clinical settings.

Storage Conditions

Store in a cool and dry place away from sunlight