Tiagra 20mg Tablet

Uses of Tiagra 20mg Tablet

• Treatment of Erectile Dysfunction
• Treatment of Pulmonary Arterial Hypertension (PAH)
• Treatment of Benign Prostatic Hyperplasia (BPH)

How does Tiagra 20mg Tablet work?

It helps reduce symptoms of an enlarged prostate gland, such as difficulty peeing or needing to pee urgently, by relaxing the muscles in the prostate and bladder.

It helps pulmonary hypertension by relaxing blood vessels in the chest. This increases blood supply to the lungs and reduces the workload of the heart.

Side Effects of Tiagra 20mg Tablet

Side effects may include flushing, headache, blurred vision, muscle pain, stomach upset, nausea, back pain, and respiratory tract infection. If side effects are bothersome or persistent, consult your doctor.

Quick Suggestions:

• It usually takes 30 to 60 minutes for tadalafil to work for erectile dysfunction. You can take it at least 30 minutes before you want to have sex.
• Taking tadalafil alone is not enough to cause an erection. You need to be sexually aroused for it to work.
• The most common side effects are headaches, feeling sick, indigestion, and facial flushes.
• It can be dangerous to take tadalafil if you also take medicines called nitrates (often prescribed for chest pain). This combination can cause dangerously low blood pressure. If you're not sure if you're taking nitrate, ask your doctor or pharmacist.
• Do not drink grapefruit juice if you're taking tadalafil for pulmonary hypertension. It affects the way the medicine works.

Indications:

Tadalafil is used for Erectile Dysfunction.

Pharmacology

Tadalafil is a PDE5 inhibitor, which means it specifically blocks phosphodiesterase type 5 (PDE5). When PDE5 is inhibited, it leads to an increase in cyclic guanosine monophosphate (cGMP) levels within smooth muscle cells. This elevation of cGMP results in the relaxation of smooth muscles, ultimately leading to improved blood flow into the corpus cavernosum of the penis, thereby facilitating an erection.

Notably, PDE5 is also present in the smooth muscles of the prostate and bladder wall. By inhibiting PDE5, cGMP levels are boosted, causing relaxation of these smooth muscles. This relaxation can enhance blood flow within the urinary system and widen the opening of the bladder neck, potentially improving the process of voiding or urination.

Dosage & Administration of Tiagra 20mg Tablet

Here is the information about the dosages of tadalafil for various conditions:

Dose for Erectile Dysfunction:

• The usual dose of tadalafil for erectile dysfunction is 10mg when needed.
• Do not take more than one tablet a day.
• Your doctor may adjust your dose based on how well it works and how often you take it.
• The effects of tadalafil may last longer than 24 hours, so it's not recommended to take the 10mg or 20mg tablets daily.
• For the tablet to be effective, you need to be sexually aroused.

Dose for Benign Prostate Enlargement (BPH):

• Tadalafil for an enlarged prostate comes in 2.5mg or 5mg tablets.
• The usual dose is 5mg, taken once a day.
• If you're being treated for both BPH and erectile dysfunction, the dose is 5mg.

Dose for Pulmonary Hypertension:

• Tadalafil for pulmonary hypertension is available in 20mg tablets.
• The usual dose is 40mg, which means taking two 20mg tablets once a day.
• If you have kidney or liver problems, your doctor might start you on a lower dose of 10mg or 20mg.

Always follow your doctor's instructions regarding the dose and how to take tadalafil, and do not hesitate to consult with your healthcare provider if you have any questions or concerns about your medication.

How to Take It:

• Swallow your tablets whole with water or juice (avoid grapefruit juice).
• For erectile dysfunction, take 1 tablet at least 30 minutes before sexual activity.
• If you're taking tadalafil for prostate enlargement, you can take your tablet in the morning or evening, but it's best to take it at the same time each day.
• Tadalafil tablets for pulmonary hypertension are larger and may be challenging to swallow.

If You Forget to Take It:

• If you have benign prostate enlargement, take it as soon as you remember and continue as usual.
• For pulmonary hypertension, take it within 8 hours if possible. If you remember after 8 hours, skip the missed dose and take the next one at the usual time.
• Never take two doses at the same time or an extra dose to make up for a missed one.

If You Take Too Much:

• Taking too much tadalafil can lead to side effects such as headache, dizziness, indigestion, stuffy nose, and changes in vision (e.g., blurred vision).

Interaction

Tadalafil can potentiate the hypotensive effects of nitrates, alpha-blockers, antihypertensives, or alcohol. CYP3A4 inhibitors (e.g. ketoconazole, ritonavir) increase Tadalafil exposure. For concomitant use with potent CYP3A4 inhibitors, dose adjustment may be needed. CYP3A4 inducers (e.g. rifampin) decrease Tadalafil exposure.

Contraindications

Administration of Tadalafil to patients who are using any form of organic nitrate, either regularly and/or intermittently, is contraindicated. In clinical pharmacology studies, Tadalafil was shown to potentiate the hypotensive effect of nitrates.

Tadalafil and Pregnancy:

• Tadalafil is not commonly prescribed during pregnancy, but it may be considered if you have pulmonary hypertension, which is a serious condition.
• Women with pulmonary hypertension are advised to use reliable contraception methods and consult their doctors before attempting to conceive.
• If pregnancy occurs while taking tadalafil for pulmonary hypertension, it is typically recommended to continue the medication because the risks associated with pulmonary hypertension can be life-threatening without treatment.
• Pregnant individuals taking tadalafil need specialized care and should be monitored in a pregnancy and heart clinic as they are considered high-risk pregnancies.

Tadalafil and Breastfeeding:

• Tadalafil is not typically prescribed to breastfeeding individuals unless a specialist recommends it.
• If you are breastfeeding and have pulmonary hypertension, you should consult with a healthcare professional for guidance on the appropriate treatment options and potential risks.

Precautions & Warnings

Tadalafil should not be used together with nitrate medication, such as nitroglycerin (Nitro Dur, Nitrolingual, Nitrostat, Transderm Nitro, and others), isosorbide dinitrate (Dilatrate, Isordil, Isochron), isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking Tadalafil with nitrate medicine for chest pain or heart problems can cause a sudden and serious decrease in blood pressure. severe impairment of pulmonary or renal function; moderate impairment of hepatic function; and toxic psychosis. Use not recommended in patients with a recent MI (within 90 days) or stroke (within 6 months); uncontrolled arrhythmias, hypotension (<90/50 mm Hg systolic/diastolic BP), or uncontrolled hypertension (170/110 mm Hg systolic/diastolic BP); heart failure (>NYHA class II) in the previous 6 months; or those with unstable angina or angina occurring during sexual intercourse. Possible hypotension, particularly in patients with left-ventricular outflow obstruction (e.g., aortic stenosis, idiopathic hypertrophic subaortic stenosis) and in patients with severely impaired autonomic control of blood pressure.

Storage Conditions

Store in a cool and dry place, protected from light. Keep out of reach of children