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Generic Name: Hydrocortisone 1% + Miconazole Nitrate 2% Topical
Company Name: ACI Limited
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✅ Description:
Indications
For the topical treatment of inflamed dermatoses where infection by susceptible organisms and inflammation coexist e.g. intertrigo and infected eczema. For moist or dry eczema or dermatitis including atopic eczema, primary irritant or contact allergic eczema, or seborrheic eczema including that associated with acne. Also for intertriginous eczema including inflammatory interior, perianal and genital dermatitis. Organisms that are susceptible to miconazole are dermatophytes and pathogenic yeasts (e.g. Candida spp.): also many Gram-positive bacteria including many strains of Streptococcus and Staphylococcus.
Pharmacology
Miconazole is a substituted imidazole, is one of the family of azoles useful in treating superficial candidiasis and skin infections dermatophytosis and pityriasis versicolor, acanthamoeba, seborrheic dermatitis. Also active against Aspergillus spp., Cryptococcus neoformans, Pseudalescheria boydii, and some gram-positive bacteria including Staphylococci and Streptococci.
Hydrocortisone is a naturally occurring glucocorticoid that's now prepared synthetically. Its important function is in skin injuries such as inflammation. Also, it has antipruritic, antimycotic, and vasoconstrictive activity.
Miconazole is an imidazole antifungal agent that interferes with ergosterol synthesis and therefore alters the permeability of the cell membrane of sensitive fungi. This causes the killing of fungi, when applied to the skin, Hydrocortisone is absorbed into the skin cells. It prevents the release of certain chemicals, which is responsible for inflammation. Thus hydrocortisone reduces inflammation.
Dosage & Administration
Apply to the affected area as a thin film two or four times daily for 1 to 2 weeks. Rub it well with your finger until this cream entirely vanished on the skin. Treatment should be continued for at least one week after all signs and symptoms disappear. The same dosage applies to both adults and children.
Interaction
Amphotericin antagonizes the activity of Miconazole.
Contraindications
It is contraindicated in individuals who are hypersensitive to it or any of its components. It should not be used in pregnant mothers and lactating mothers without a physician's advice.
Side Effects
Rarely local sensitivity may occur. Long-term use may decrease the production of natural hormones by the adrenal gland.
Pregnancy & Lactation
Administration of corticosteroids to pregnant animals at high doses can cause abnormalities in fetal development. Topical steroids should not be extensively used in pregnancy.
Precautions & Warnings
To be dispensed only on the prescription of a registered physician. Keep out of reach of children. Take care or consult with a physician in case of use in children and elderly people for long-term use.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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