Gonal-F 75IU (5.5mcg) Injection

✔️ Gonal-F 75IU injection is used for:

• Assisted Reproductive Technologies (ART)
• Ovulation Induction
• Treatment of Male Infertility
• Hypogonadism

✔️ How does

Follitropin alfa, the active ingredient in Gonal-F, is a recombinant form of human follicle-stimulating hormone (FSH). In women, it stimulates the growth of ovarian follicles in the absence of primary ovarian failure. In men with hypogonadotropic hypogonadism, it helps stimulate spermatogenesis.

✔️ Side Effects of Gonal-F 75IU Injection

Like all medications, Gonal-F 75IU can cause side effects, though not everyone will experience them.

Serious Side Effects:

• Severe Skin Reactions
• Ovarian Hyperstimulation Syndrome (OHSS)
• Allergic Reactions
• Ectopic Pregnancy
• Blood Clots

Common Side Effects:

• Injection Site Reactions
• Abdominal Discomfort
• Nausea
• Headache
• Fatigue

✔️ Quick Suggestions:

• The injection is administered under the skin. Follow the recommended dosage and monitoring schedules to minimize the possibility of ovarian hyperstimulation.
• Inform your doctor immediately if you have severe pelvic pain, nausea, vomiting, diarrhea, sudden weight gain, trouble breathing, or decreased or no urination during treatment, as these could be symptoms of ovarian hyperstimulation syndrome (OHSS).
• Do not use Gonal-F 75IU Injection if you are already pregnant or breastfeeding.
• It may also be used to stimulate sperm formation in men.
• Gonal-F 75IU Injection stimulates the production of eggs in women undergoing infertility treatment.
• Your doctor may prescribe more than one medicine as part of your suggested pregnancy plan.
• Pregnancy following treatment with Gonal-F 75IU Injection is more likely to result in a multiple pregnancy (twins or more).

✔️ Indications:

Gonal-F 75IU Injection contains Follitropin alfa which is a type of Follicle follicle-stimulating hormone produced naturally by the body. It is used in women who are unable to ovulate. It works by stimulating the growth of follicles (which contain eggs) in the ovary. This helps in the release of a properly developed egg at the time of ovulation. It is also used in assisted reproductive technology (ART) procedures such as in-vitro fertilization (IVF), which helps women to become pregnant. It may also be used in adult men who are infertile due to a lack of certain hormones and an inability to produce enough sperm cells.

✔️ Pharmacology

Gonal-F 75IU, a recombinant form of follicle-stimulating hormone (FSH), works by binding to FSH receptors in ovarian granulosa cells in women or Sertoli cells in men. In females, this promotes the growth and development of ovarian follicles, leading to egg maturation, while in males, it enhances sperm production and maturation. By replicating the action of natural FSH, it aids in regulating reproductive processes and is a valuable tool in infertility treatments.

✔️ Dosage:

Female Infertility: The dosage should be individualized. The initial recommended dose is 75 IU/day, which can be increased by 37.5 IU after 14 days if necessary. Further increases can be made every 7 days, with a maximum dose of 300 IU/day. If the response is adequate, human chorionic gonadotropin (hCG) should be administered 1 day after the last Gonal-F dose.

Assisted Reproductive Technologies (ART): Start with 150-225 IU/day for at least 4 days, starting on day 2 or 3 of the menstrual cycle. Adjust the dose based on ovarian response, with a maximum of 450 IU/day. Once adequate follicular development is achieved, administer hCG to induce final follicular maturation. hCG should be withheld if the ovaries are abnormally enlarged.

Spermatogenesis Induction: Administer 150 IU three times per week, along with continued chorionic gonadotropin, for at least 4 months. The maximum dose is 300 IU three times per week.

(Always take this medication as per the advice of a registered physician.)

✔️ How to Use Gonal-f 75IU Injection

Gonal-F 75IU injection is administered subcutaneously. Patients are given clear instructions on how to properly and safely administer the injection during their treatment period.

✔️ Interaction of Gonal-F 75IU Injection with Other Drugs

Patients should inform their doctor about any medications they are taking, including prescription drugs, over-the-counter medications, supplements, and herbal products. Some medicines may interact with Gonal-F 75IU injection, reducing its effectiveness or causing unwanted side effects.

✔️ Contraindications

• Hypersensitivity to the medication
• Undiagnosed abnormal genital bleeding
• Sex hormone-sensitive cancers of the reproductive tract or accessory organs
• Intracranial lesions like pituitary tumors
• Ovarian cysts or enlargement of unknown origin
• Elevated FSH levels indicative of primary gonadal failure
• Uncontrolled thyroid or adrenal dysfunction
• Pregnancy or breastfeeding

✔️ Pregnancy, Fertility & Lactation

Pregnancy Category X: Gonal-F is contraindicated during pregnancy as it can cause fetal abnormalities. Studies show clear evidence of fetal risk in humans, and the risks outweigh any potential benefits. 

Gonal-F is also not recommended for use in breastfeeding women

✔️ Precautions & Warnings

• Patients using Gonal-F 75IU should be aware of potential risks like Ovarian Hyperstimulation Syndrome (OHSS), multiple pregnancies, and ectopic pregnancy. 
• Women with asthma or respiratory conditions should use this medication cautiously, and those with pre-existing heart conditions need close monitoring. 
• Fertility treatments can be emotionally challenging, so psychological support is recommended.  
• Gonal-F may lead to multiple births.
• There is a risk of ovarian hyperstimulation syndrome (OHSS), serious lung conditions, and thromboembolic events.
• Patients should be evaluated for hypothyroidism, adrenocortical insufficiency, hyperprolactinemia, and pituitary or hypothalamic tumors before starting therapy.
• It’s important to inform healthcare providers of your full medical history, follow prescribed dosages, and attend regular ultrasound exams to monitor progress. Proper handling, disposal, and informed consent are essential for safe and effective treatment.

✔️ Storage Instructions for Gonal-F 75IU Injection

• Store at a temperature between 2°C to 8°C (36°F to 46°F).
• Keep away from moisture, heat, and light.
• Do not freeze.
• Keep out of reach of children and pets.

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