Rupin 10mg Tablet

Uses of Rupin 10mg Tablet

• Relieves the symptoms of allergic rhinitis and symptoms associated with urticaria

How does Rupin 10mg Tablet work?

This medicine works by reducing a chemical substance called histamine, which is responsible for causing allergic symptoms.

Side Effects of Rupin 10mg Tablet

• Headache
• Dizziness
• Dry mouth
• Fatigue
• Tiredness and weakness
• Nausea
• Abdominal pain
• Diarrhea
• Vomiting
• Constipation
• Rash

Quick Suggestions:

• Your doctor has prescribed Rupatadine to help relieve allergy symptoms such as itching, swelling, and rashes.
• As compared to other similar medications, it is much less likely to make you feel sleepy.
• Be cautious while driving or doing anything that requires concentration as it can cause dizziness and sleepiness.
• Do not drink alcohol while taking this medication as it may cause increased sleepiness.
• Stop taking Rupatadine at least three days before taking an allergy test as it can affect the test results.

Indication of Rupin 10mg Tablet

• Allergic rhinitis is an inflammation of the nose caused by an overreaction of the immune system to allergens in the air. Symptoms include a runny or stuffy nose, sneezing, itchy and watery eyes, and swelling around the eyes. Common airborne allergens that can cause allergic rhinitis include dust mites, pollen, spores, and animal skin, urine, and saliva.
• Urticaria, also known as hives, is a common skin rash that can be triggered by various factors, including certain foods, medications, and stress. Symptoms of urticaria include itchy, raised, red, or skin-colored welts on the skin's surface.

Rupin 10mg Tablet helps alleviate various symptoms of an allergic reaction. It acts as an anti-histamine, which treats hives (urticaria) and allergic rhinitis.

Pharmacology

Rupatadine is a long-acting, non-sedative antagonist that blocks histaminergic H1-receptors. Histamine is a chemical released by the body during an allergic reaction and can cause various symptoms such as bronchoconstriction (narrowing of the airways) and increased vascular permeability (leakage of fluids from blood vessels), contributing to the inflammatory process.

In addition to its action on histamine receptors, rupatadine also antagonizes the effects of platelet-activating factor (PAF). PAF is involved in various inflammatory processes and can contribute to bronchoconstriction and increased vascular permeability.

By blocking both histamine and PAF, rupatadine helps alleviate symptoms associated with allergic reactions, such as bronchoconstriction, swelling, itching, and watery eyes. Its non-sedative properties make it a favorable option for individuals who need relief from allergies without experiencing drowsiness.

Dosage & Administration of Rupin 10mg Tablet

The recommended dosage for Rupin 10mg Tablet (Rupatadine) in adults and children for the treatment of allergic rhinitis and chronic idiopathic urticaria is as follows:

Adult Dose (Oral):

• Allergic rhinitis; Chronic idiopathic urticaria: 10 mg (1 tablet) once daily.

Child Dose (Oral):

• Allergic rhinitis; Chronic idiopathic urticaria:
  • Children > 12 years: 10 mg (1 tablet) once daily.
  • Children below 12 years: Use of Rupatadine is not recommended.

For children aged 2 to 11 years, Rupatadine is available in syrup form. The recommended dosage for children is as follows:

• For children weighing 10 kg to less than 25 kg: 1/2 teaspoonful (2.5 ml) syrup once a day with or without food.
• Children weighing 25 kg or more: 1 teaspoonful (5 ml) of syrup once a day with or without food.

It is important to take Rupin 10mg Tablet(Rupatadine) as advised by your physician. Swallow the tablet with a glass of water and do not chew or crush it. The correct dose and duration of treatment will be determined by your doctor based on factors such as your age, body weight, and the specific condition being treated.

Always follow your doctor's instructions and consult them if you have any questions or concerns about the dosage or usage of Rupin 10mg Tablet (Rupatadine).

Interaction

Rupin 10mg Tablet can interact with several medications, and caution should be exercised when using it in combination with the following:

• Other antihistamines (such as diphenhydramine): Concurrent use may increase the risk of side effects and sedation.
• Benzodiazepines (such as midazolam): Co-administration may enhance the sedative effects of both medications.
• Antibiotics (such as erythromycin): Erythromycin can inhibit the metabolism of Rupin 10mg Tablet, leading to increased levels of the medication in the body.
• Antifungals (such as itraconazole, ketoconazole, fluconazole, voriconazole, and posaconazole): These medications can inhibit the metabolism of Rupin 10mg Tablet, potentially leading to increased levels and effects.
• HIV protease inhibitors (such as indinavir, and ritonavir): Co-administration may increase the levels of Rupin 10mg Tablet in the body.
• Antidepressants (such as nefazodone): Concurrent use may increase the risk of side effects and sedation.
• Calcium channel blockers (such as diltiazem): Combination use may lead to additive effects on heart rate and blood pressure.
• Statins (such as atorvastatin): Concurrent use may increase the risk of statin-related muscle side effects.
• Immunosuppressive drugs (such as cyclosporin, tacrolimus, sirolimus, and everolimus): Co-administration may increase the risk of immunosuppression and related adverse effects.
• Cisapride: Concurrent use with Rupin 10mg Tablet is contraindicated due to the risk of serious cardiac arrhythmias.

Regarding drug-food interactions, it is advised to avoid consuming alcohol and grapefruit juice while taking Rupin 10mg Tablet, as they may increase the risk of side effects or alter the medication's effectiveness.

Rupin 10mg Tablet is contraindicated in individuals with kidney diseases, hepatic diseases, heart diseases, galactose intolerance, and glucose-galactose malabsorption. It is important to inform your doctor about any pre-existing medical conditions you may have before starting Rupin 10mg Tablet.

It is essential to consult with a healthcare professional or pharmacist for a comprehensive understanding of potential drug interactions and any precautions specific to your individual circumstances.

Contraindications

Rupin 10mg Tablet is contraindicated in individuals who have a known hypersensitivity or allergy to Rupatadine or any of the excipients (inactive ingredients) present in the medication. Hypersensitivity reactions can range from mild symptoms like rash and itching to severe allergic reactions that may involve difficulty breathing, swelling, and anaphylaxis.

If you have a known hypersensitivity to Rupatadine or any components of Rupin 10mg Tablet, it is important to inform your healthcare provider before starting the medication. They will be able to recommend alternative treatment options or medications that are better suited for you.

Pregnancy & Lactation

There is no clinical data available on the exposure of Rupatadine during pregnancy. Pregnant women should therefore not use Rupatadine unless the potential benefit outweighs the potential risk for the infant. No information is available, on whether Rupatadine is excreted in the mother's milk. Therefore, it should not be used during lactation, unless the potential benefits for the mother justify the potential risk to the infant.

Precautions & Warnings

• Allergy: Do not take Rupin 10mg Tablet if you are allergic to Rupin 10mg Tablet itself. If you have a known hypersensitivity or allergy to Rupatadine or any of the ingredients in Rupin 10mg Tablet, it is important to inform your doctor.
• Other Medications: Inform your doctor about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. This is important to ensure there are no potential interactions or contraindications.
• Pregnancy and breastfeeding: If you are pregnant, planning to get pregnant, or breastfeeding, it is essential to inform your doctor before taking Rupin 10mg Tablet. They will be able to evaluate the potential benefits and risks and provide appropriate guidance.
• Elderly patients: Caution should be exercised when using Rupin 10mg Tablet in elderly patients (age > 65 years) due to an increased risk of severe adverse effects. Close monitoring and appropriate dosage adjustments may be necessary.
• Heart, kidney, and liver patients: Rupin 10mg Tablet should be used with caution in patients with heart, kidney, or liver conditions. Your doctor will evaluate your specific condition and determine if any adjustments or precautions are necessary.
• Galactose intolerance and lactose malabsorption: Rupin 10mg Tablet contains lactose monohydrate. If you have rare hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption, you should not take this medicine. Inform your doctor about these conditions.
• Alcohol: It is advisable to avoid alcohol while taking Rupin 10mg Tablet, as it may cause adverse effects and potentially enhance the sedative properties of the medication.
• Drowsiness and driving: Rupin 10mg Tablet may cause drowsiness. If you experience drowsiness, it is important not to drive or operate machinery until you know how the medication affects you.

Storage Conditions

Store in a cool & dry place below 30°C, and protect from light & moisture. Keep out of reach of children.