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Infovir 20Pcs (Box)
Tablet, Generic Name: Adefovir Dipivoxil, Manufacturer: Incepta Pharmaceuticals Ltd.
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✅ Description:
Infovir is indicated for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Dosage & Administration
The recommended dose of Adefovir for the treatment of chronic hepatitis B in adolescent & adults (age ≥ 12 year) with adequate renal function is 10 mg, once daily, taken orally, without regard to food
Dose Adjustment in Renal Impairment: Significantly increased drug exposures are seen when Adefovir Dipivoxil is administered to patients with renal impairment. Therefore, the dosing interval of Adefovir Dipivoxil should be adjusted in patients with baseline creatinine clearance < 50 mL/min using the following suggested guidelines-
Dosing interval adjustment of Adefovir in patients with renal impairment
| Creatinine clearance(mL/min) | > 50 | 20 to 49 | 10 to 19 | < 10 Hemodialysis or CAPD |
|---|---|---|---|---|
| Recommended dose and dosing interval | 10 mg every 24 hours | 10 mg every 48 hours | 10 mg every 72 hours | 10 mg every 7 days |
Side Effects
Treatment-related clinical adverse events that occurred in 3% or greater of Adefovir Dipivoxil-treated patients compared with placebo are asthenia, headache, abdominal pain, nausea, flatulence, diarrhea, dyspepsia.
Precautions
Severe acute exacerbation of hepatitis has been reported in patients who have discontinued anti-hepatitis B therapy, including therapy with Adefovir Dipivoxil. Patients who discontinue Adefovir Dipivoxil should be monitored at repeated intervals over a period of time for hepatic function. If appropriate, resumption of anti-hepatitis B therapy may be warranted.
Chronic administration of Adefovir Dipivoxil (10 mg once daily) may result in nephrotoxicity. The overall risk of nephrotoxicity in patients with adequate renal function is low.
However, this is of special importance in patients at risk of or having underlying renal dysfunction and patients taking concomitant nephrotoxic agents such as cyclosporine, tacrolimus, aminoglycosides, vancomycin and non-steroidal anti-inflammatory drugs.
Use in Pregnancy & Lactation
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Therfore, Adefovir Dipivoxil should be used during pregnancy only if clearly needed and after careful consideration of the risks and benefits.
Lactation: It is not known whether Adefovir is excreted in human milk. Mothers should be instructed not to breast-feed if they are taking Adefovir Dipivoxil.
Over Dose
If overdose occurs the patient must be monitored for evidence of toxicity, and standard supportive treatment applied as necessary.
Commercial Pack
Infovir tablet: Each box contains 2 blister strips of 10 tablets.
Others
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
Geriatric Use
In general, caution should be exercised when prescribing to elderly patients since they have greater frequency of decreased renal or cardiac function due to concomitant disease or other drug therapy.
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