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Tamoxen 20mg Tablet 1 Strip
Tamoxen is prescribed for the treatment of breast cancer.
✅ Description:
Tamoxifen is a non-steroidal selective estrogen receptor modulator (SERM). It binds to estrogen receptors (ER), altering their structure and blocking or modifying the transcription of estrogen-responsive genes. This action leads to reduced DNA polymerase activity, decreased thymidine uptake, inhibited estradiol binding, and reduced estrogen response. Depending on the tissue, Tamoxifen can exert both estrogenic and anti-estrogenic effects by interacting with coactivators or corepressors and binding to ER-alpha or ER-beta receptors.
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✔️ Side Effects:
Tamoxen may cause both estrogen-related and general side effects, including:
- Hot flushes, vaginal discharge/bleeding, pruritus vulvae, tumor flare
- Gastrointestinal discomfort, headache, dizziness, fluid retention, hair thinning
- Skin rashes, rare severe reactions like Stevens-Johnson syndrome
- Visual issues: Retinopathy, corneal changes, increased risk of cataracts
- Hematologic changes: Leucopenia, anemia, thrombocytopenia, neutropenia
- Liver dysfunction: Changes in liver enzyme levels, cholestasis, fatty liver
- Reproductive system effects: Endometrial changes, fibroids, ovarian cysts
- Thromboembolic events: DVT, pulmonary embolism
Rarely, elevated triglycerides, potentially leading to pancreatitis
✔️ Dosage & Administration:
Adults (including elderly):
The recommended daily dosage is 20 to 40 mg, taken as a single dose or divided into two doses.
✔️ Drug Interactions:
Coumarin anticoagulants: Concurrent use may increase anticoagulant effect, requiring close monitoring.
Cytotoxic agents: Co-administration may raise the risk of thromboembolic events.
✔️ Contraindications:
Pregnancy: Tamoxen should not be taken during pregnancy.
Hypersensitivity: Not for use in patients allergic to tamoxifen or any of its components.
✔️ Pregnancy & Lactation
Pregnancy: Tamoxen is contraindicated during pregnancy. Although some birth defects and fetal deaths have been reported, no direct link has been established. Patients should avoid pregnancy while taking Tamoxen and for at least two months after stopping. Non-hormonal contraceptives are advised.
Lactation: It’s unclear if tamoxifen is excreted in breast milk. Use is not recommended while breastfeeding. A healthcare provider should assess the importance of continuing the drug for the mother.
✔️ Precautions & Warnings
Menstrual irregularities may occur in premenopausal women.
Increased risk of endometrial cancer has been observed, possibly due to estrogen-like effects of tamoxifen.
Any abnormal gynecological symptoms, especially vaginal bleeding, should be evaluated.
Rare reports of secondary tumors (excluding the endometrium or opposite breast) have been noted; their significance is unclear.
✔️ Storage:
Store at 20–25°C, away from light.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
