Orthogen Tablet

How does Orthogen Tablet work?

Undenatured Type II collagen (UC-II): UC-II is sourced from chicken sternum cartilage and acts through a unique mechanism of action, promoting oral tolerization. It reduces joint inflammation and supports cartilage repair.

Glucosamine sulfate: A natural supplement that aids in cartilage formation and can prevent structural changes in the joints of osteoarthritis patients.

Boswellia serrata: This plant extract enhances joint health by inhibiting inflammatory factors and potentially reducing cartilage damage in individuals with arthritis.

Boron (calcium fructoborate): A plant-mineral complex that helps maintain bone health by managing inflammation linked to the loss of bone mineral density.

Side Effects

The combination of Undenatured Type II collagen, Glucosamine, Boswellia, and boron is generally well-tolerated in the recommended dose. Overdose may cause headache & constipation.

Uses:

Improves joint mobility, flexibility, and comfort by preventing the immune system from attacking and damaging the articular cartilage

Overdose Effects:

The signs and symptoms of overdose include nausea, vomiting, diarrhea, constipation, and abdominal discomfort.

Quick Suggestions:

• This comprehensive joint health supplement is designed to support your range of motion, promote joint comfort, and enhance joint health. It features innovative ingredients such as type II collagen, Boswellia, glucosamine, and boron.
• Type II collagen, specifically NT2 Collagen, is included in this formula to provide the best collagen for maintaining comfortable joints.
• Type II collagen is essential for promoting joint health and comfort because it closely resembles the collagen found in your joints, which serves as a shock-absorbing cushion.
• Glucosamine has been shown in randomized controlled clinical trials to help maintain comfortable joint function and support healthy joint structure when used over the long term.
• Boron is another key ingredient that contributes to healthy bones and joints. Additionally, Boswellia serrata, a plant extract, promotes joint health and helps maintain a healthy inflammatory response.

Indication

This preparation is indicated in:

• Osteoarthritis & rheumatoid arthritis
• Difficulties in flexibility & mobility
• Joint pain & inflammation
• Joint discomfort & stiffness (knee extension)
• Impaired joint function

Pharmacology

Undenatured Type II collagen (UC-II): Derived from chicken sternum cartilage, UC-II has a unique mechanism of action. UC-II molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization, active epitopes of UC-II interact with Peyer’s patches of the small intestine and transform T-cells into T-regulatory cells, which migrate to the joint area, reduce joint inflammation, and promote cartilage repair.

Glucosamine sulfate: A natural supplement that helps build cartilage, glucosamine sulfate is a normal constituent of glycosaminoglycans in the cartilage matrix and synovial fluid. In randomized, placebo-controlled clinical trials, long-term administration of glucosamine sulfate can prevent joint structure changes in patients with knee osteoarthritis with a significant improvement in symptoms.

Boswellia serrata: This plant extract promotes joint health by inhibiting inflammatory factors such as the 5-lipoxygenase (5-LOX) enzyme and leukotriene B4, which affect aging joints. Boswellia extract improves signs of joint discomfort in just 8 weeks, making it a promising alternative to NSAIDs.

Boron (calcium fructoborate): This patented complex reduces C-reactive protein in humans and contributes to bone health by controlling inflammation associated with loss of bone mineral density.

Dosage & Administration of

• Adult dose: 1 tablet orally twice daily after a meal or as directed by the physician.
• Use in children & adolescents: Safety and effectiveness in children patients below 12 years of age have not been established.

Interaction

There have been no reports of significant drug interactions with UC-II, Boswellia serrata, Glucosamine sulfate, and Calcium fructoborate. But in the case of Glucosamine sulfate & Boswellia serrata, there is a chance of drug interaction with blood thinner medications (e.g., warfarin & heparin).

Contraindications

Contraindicated in patients with known hypersensitivity to chicken, egg & shellfish.

Pregnancy & Lactation

Not recommended during pregnancy and lactation.

Precautions & Warnings

No special studies were confirmed in patients with renal and/or hepatic insufficiency. However, administration to these patients with severe renal or hepatic insufficiency should be under appropriate medical supervision.

Storage Conditions

Store below 30°C temperature & in a dry place, protected from light. Keep out of the reach of children.