Zimax Suspension 50ml

Uses of Zimax Suspension

• Treatment of Bacterial Infections

How Zimax Suspension works?

works by reducing bacterial protein synthesis (which is required for the bacterium to proliferate), resulting in its death and so stopping its growth and infection spread in afflicted individuals.

Side Effects of Zimax Suspension

• Diarrhea
• Stomach pain
• Difficult or painful urination
• Nausea and vomiting
• Fever
• Acid or sour stomach
• Excessive air or gas in the stomach
• Chest pain
• Dizziness
• Loss of appetite

Quick Suggestions

• Your child must complete the entire course of this medicine. Stopping too soon may cause the bacteria to multiply again, become resistant, or cause another infection.
• Give Zimax Suspension 200mg/5ml with food to avoid an upset stomach.
• Encourage your child to drink plenty of water in case diarrhea develops as a side effect.
• Zimax Suspension 200mg/5ml will not be effective for viral infections. However, the doctor may prescribe this medicine in case of a secondary bacterial infection. So make sure to speak to your child’s doctor first.
• Avoid taking too many calcium-enriched foods and drinks as it might affect the working of Zimax Suspension.
• Only give Zimax Suspension 200mg/5ml  to your child for their current infection. Never save medicine for future illnesses.
• Stop the medicine and contact the doctor immediately if your child develops an itchy rash, facial swelling, and breathing difficulties soon after the intake.

Indications of Zimax Suspension

Used in pediatric patients:

• To treat infections caused by bacteria and other micro-organisms which include chest, throat, and nasal infections
• To treat ear infections such as acute otitis media and skin & soft tissue infections such as abscesses or boil
• To treat sexually transmitted diseases caused by organisms such as chlamydia trachomatis/ Neisseria gonorrhea

Pharmacology

Azithromycin can be taken orally without the need for protection from stomach acids since it is acid-stable. The drug is rapidly absorbed, and its absorption is more noticeable on an empty stomach. Peak concentration is typically reached in 2.1 to 3.2 hours for oral forms in adults. Azithromycin is effectively transported to the site of infection due to its high concentration in phagocytes. It is highly lipid soluble and can be caught by particles, leading to its concentration in tissues being over 50 times higher than in plasma.

A single large dose of azithromycin can maintain bacteriostatic levels in infected tissue for several days because of its long half-life. The mean apparent plasma clearance is 630 mL/min, and the terminal elimination half-life is 68 hours after a single 500 mg dose. The drug's significant absorption and subsequent release from tissues prolong the terminal half-life. Biliary excretion is one of the primary elimination pathways for azithromycin, with urinary excretion accounting for about 6% of the prescribed dose.

Examples of gram-positive, facultative, aerobic bacteria susceptible to azithromycin include Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, and Streptococcus pyogenes. Examples of gram-negative, aerobic, and facultative bacteria include Neisseria gonorrhoeae, Haemophilus influenzae, Moraxella catarrhalis, and Haemophilus ducreyi. Non-bacterial microorganisms, such as Mycoplasma pneumoniae, Chlamydia pneumoniae, and Chlamydia trachomatis, are also susceptible to azithromycin. The production of beta-lactamase should not affect azithromycin's efficacy. Gram-positive, aerobic, and facultative bacteria from the Streptococcus genus (Groups C, F, and G) and from the Viridans genus are also susceptible to azithromycin.

Dosage & Administration of Zimax Suspension

This medication can be taken orally in tablet or suspension form, with or without food depending on the type of medication. The oral suspension should be used within 10 days after reconstitution. The extended-release oral suspension should be taken on an empty stomach within 12 hours of reconstitution and is only given in a single dose.

• For adults, the recommended doses vary depending on the condition being treated, ranging from 500mg once daily for 3 days to 2g as a single dose. There is no need for dosage adjustment for elderly or hepatically impaired patients, and no adjustment is needed for renal-impaired patients either.
• For children, the recommended dose varies based on the condition being treated and the child's weight, with doses ranging from 10mg/kg/day to 60mg/kg once. Renal impairment does not require dosage adjustment.

Administer Zimax Suspension to the kid as directed by your doctor. Shake vigorously before using. The specific amount and length of treatment for your kid will be determined by your doctor based on the child's age, body weight, and medical status.

Interaction

ZiMax absorption is lowered when food and antacids are present. ZiMax should not be used in patients who are receiving ergot alkaloids because it may cause ergotism due to an interaction between azithromycin and the cytochrome P-450 system. When administering digoxin and cyclosporin at the same time, care should be taken because macrolides raise their plasma concentrations. Azithromycin does not interact with Warfarin, Theophylline, Carbamazepine, Methylprednisolone, or Cimetidine.

Contraindications

Patients who are hypersensitive to azithromycin or any other macrolide antibiotic should avoid taking it. Ergot derivatives and azithromycin should not be taken together. Patients with hepatic disorders should avoid azithromycin.

Pregnancy & Lactation

Zimax belongs to category B for use during pregnancy. Animal studies have shown that Azithromycin does not have any harmful effects on the developing fetus. However, there is not enough research on pregnant women to confirm its safety. Therefore, Azithromycin should only be used during pregnancy if it is absolutely necessary and there are no other options available.

It is not known whether Zimax is present in breast milk. Hence, if Azithromycin is given to a nursing woman, caution should be exercised.

Precautions & Warnings

• If you have liver problems such as jaundice, muscle problems like myasthenia gravis, heart rhythm disorder such as arrhythmia, or electrolyte imbalance like low potassium or magnesium levels, you should inform your doctor before taking Zimax Suspension.
• This medicine may cause diarrhea in rare cases, and if you experience watery or bloody diarrhea, stop taking the medicine and contact your doctor immediately. However, do not take any anti-diarrheal medication without consulting your doctor first.
• It is unclear whether Zimax Suspension can harm the baby during pregnancy. If you are pregnant, planning to become pregnant, or breastfeeding, you should consult your doctor before using Zimax Suspension. If you are allergic to azithromycin or other macrolide antibiotics, do not take Zimax Suspension.
• Inform your doctor if you are using cholesterol-lowering medications like simvastatin or lovastatin, anti-gout or anti-arthritis drugs like colchicine, or medication for treating overactive bladder like tolterodine.
• Zimax Suspension is not recommended for patients with pneumonia who are considered unsuitable for oral therapy due to moderate to severe illness or risk factors.

Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children's reach.