Xorel 20mg Capsule

Uses of Xorel 20mg Capsule

• Treats Gastro-Esophageal Reflux Disease
• Treats and Prevents Peptic Ulcers
• Treats Zollinger-Ellison syndrome

How does Xorel 20mg Capsule work?

Xorel 20mg Capsule is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances of acid reflux into the esophagus, heals peptic ulcers and esophageal lesions, and prevents its recurrence.

Side Effects of Xorel 20mg Capsule

• Nausea
• Headache
• Diarrhea
• Stomach pain
• Back pain
• Cough
• Vomiting
• Dizziness

Quick Suggestions:

• Xorel 20mg Capsule is a prescription medication used to treat stomach and intestinal ulcers, heartburn, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. The active ingredient in it is rabeprazole. Do not take this medicine for any other condition other than that specified by your doctor.
• Take this medicine in the exact dose and duration as recommended. Do not take more than the prescribed dose.
• Before starting Xorel 20mg Capsule, inform your doctor if you are pregnant, planning on becoming pregnant, or breastfeeding. Also, tell your doctor about all your other medicines and your complete medical history.
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• This medicine can be taken on an empty stomach 30 minutes before food.
• Headache, abdominal pain, diarrhea, and nausea/vomiting may occur in some individuals with the use of this medicine. Inform your doctor if these effects bother you or do not go away.
• If you experience dizziness or blurred vision after taking Xorel 20mg Capsule, it is recommended to avoid driving, operating heavy machinery, or performing any such tasks that require mental alertness.
• You can make certain lifestyle modifications like preventing excess intake of foods that cause acidity like carbonated drinks and oily/fried food, regular exercise, and maintaining a healthy weight.
• It is also advised to limit alcohol intake and quit smoking for better treatment of your acid reflux.

Indication

The most well-known utilization of Xorel 20mg Capsul is

• Heartburn
• Stomach Ulcers
• Zollinger-Ellison Syndrome
• Other Forms Of Ulcers
• Erosive Esophagitis
• Gastroesophageal Reflux Disease
• Helicobacter Pylori Infection

Pharmacology

Rabeprazole reduces gastric acid production by inhibiting the gastric H+/K+-ATPase at the secretory membrane of the gastric parietal cell. Because this enzyme is thought to be the acid (proton) pump within the parietal cell, rabeprazole has been classified as a gastric proton-pump inhibitor.

Dosage & Administration of

Adult Dose:

• Gastro-esophageal reflux disease: Initially, 20mg once daily for 4-8 weeks. The maintenance dose is either 10mg or 20mg per day, to be taken earlier in the morning.
• Zollinger-Ellison syndrome: Initially, 60mg once daily in the morning, with a maximum dose of 120mg per day if needed. Daily doses exceeding 100mg should be divided into two doses.
• Peptic ulcer: 20mg once daily in the morning for 4-8 weeks for duodenal ulcer, or 6-12 weeks for gastric ulcer.
• H. pylori infection: Combination therapy for 1 week. Xorel 20mg Capsule twice daily combined with clarithromycin and either amoxicillin or metronidazole.
• Erosive esophagitis: 20mg per day for 4-8 weeks. The maintenance dose is either 10mg or 20mg per day, to be taken once in the morning.

Child Dose:

Delayed-release capsule (sprinkles):

• <1 year: Safety and efficacy not established.
• 1-11 years (<15 kg): 5mg once daily, 30 minutes before a meal, for up to 12 weeks. The dose may be increased to 10mg daily if the response is inadequate.
• 1-11 years (>15 kg): 10mg once daily, 30 minutes before a meal, for up to 12 weeks.

Delayed-release tablet:

• <12 years: Safety and efficacy not established.

12 years: 20mg once daily for up to 8 weeks.

Renal Dose:

• No dosage adjustment is needed for patients with renal impairment.

Please note that this dosage information is a general guideline, and individual dosing may vary based on factors such as the patient's condition, response to treatment, and the prescribing physician's judgment. Always follow your doctor's instructions and consult with them for personalized dosage recommendations specific to your situation.

Administration:

Follow your physician's advice: Take Xorel 20mg Capsule as advised by your physician. They will determine the appropriate dose and duration of therapy based on factors such as your age, body weight, and the specific condition being treated.

Swallow with water: Take the tablet with a glass of water. Do not crush or chew the tablet, as it is meant to be swallowed whole.

Timing of administration: Xorel 20mg Capsule is preferably taken in the mornings or at any time of the day before meals. This timing may help optimize its effectiveness in treating the conditions it is prescribed for.

Interaction

Drug-Food Interactions: It is advised to avoid smoking and alcohol consumption while taking Xorel 20mg Capsules. Alcohol intake can increase the production of stomach acid, leading to increased acidity and heartburn. Smoking can also worsen gastroesophageal reflux disease (GERD) symptoms.

Drug-Disease Interactions: Inform your doctor if you have the following conditions:

• Clostridium difficile-associated diarrhea: This condition may require special caution when using Xorel 20mg Capsule.
• Liver disease: Your doctor needs to be aware of any liver conditions you have, as it may impact the use of Xorel 20mg Capsule.
• Bone fractures: Long-term use of Xorel 20mg Capsule has been associated with an increased risk of bone fractures. Your doctor may consider monitoring your bone health.
• Hypomagnesemia: Xorel 20mg Capsule may cause low magnesium levels. If you have hypomagnesemia, your doctor may need to monitor your magnesium levels and adjust the treatment accordingly.

Contraindications

Rabeprazole is contraindicated in patients with known hypersensitivity to Rabeprazole, other PPIs, or any formulation component.

Pregnancy & Lactation

there are no available human data on the use ofXorel 20mg Capsule in pregnant women. The potential risk associated with its use during pregnancy is unknown. It's important to note that the background risk of major birth defects and miscarriage in the general population is estimated to be 2-4% and 15-20% of clinically recognized pregnancies, respectively.

Animal reproduction studies with rabeprazole (the active ingredient in Xorel 20mg Capsule) did not show evidence of adverse developmental effects when administered during organogenesis at doses 13 and 8 times the human area under the plasma concentration-time curve (AUC) at the recommended dose for GERD in rats and rabbits, respectively.

However, in animal studies, changes in bone morphology were observed in the offspring of rats treated with oral doses of different proton pump inhibitors (PPIs) throughout pregnancy and lactation. When the maternal administration of PPIs was confined to gestation only, there were no effects on bone physeal morphology in offspring at any age.

Considering the limited data available, it is important to consult with your healthcare provider before using Xorel 20mg Capsule during pregnancy. They can evaluate the potential benefits and risks and provide guidance based on your specific situation.

It's also important to discuss any pregnancy plans or ongoing pregnancy with your healthcare provider to ensure appropriate monitoring and management.

Precautions & Warnings

• Allergy: Do not take Razo-20 Tablet 15's if you are allergic to any of its ingredients. If you experience any signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, seek immediate medical attention.
• Medical conditions: Inform your doctor if you have a stomach tumor, or liver disease, or if you are due to have a Chromogranin A blood test. Your doctor needs to be aware of these conditions to determine the appropriate use of Xorel 20mg Capsule.
• Monitoring: Long-term use of Xorel 20mg Capsule may lead to low magnesium levels, vitamin B12 deficiency, and an increased risk of bone fractures. Your doctor may advise regular tests to monitor these conditions.
• Pregnancy and breastfeeding: Consult your doctor before starting Xorel 20mg of Capsule if you are pregnant or breastfeeding. Your doctor will assess the potential risks and benefits and provide guidance on the use of the medication during these periods.
• Drowsiness and dizziness: Xorel 20mg Capsule may cause dizziness and sleepiness. Avoid activities such as driving or operating machinery if you experience these side effects. Only engage in such activities when you are alert and capable.
• Children: Xorel 20mg Capsule is not recommended for use in children, as safety and efficacy have not been established in this population. Consult your doctor for suitable alternatives for children.
• Alcohol: Avoid consuming alcohol while taking Xorel 20mg Capsule, as it can increase drowsiness and may elevate stomach acid production.
• Clostridium difficile-associated diarrhea: Prolonged use of Xorel 20mg Capsule is associated with an increased risk of Clostridium difficile-associated diarrhea. If you develop persistent or worsening diarrhea, seek medical attention promptly.
• Regular communication with your doctor: Keep your doctor informed about your health condition and any other medications you are taking to help monitor for potential side effects or interactions.

Storage Conditions

Store in a cool and dry place, and protect from light.