Servipep 40mg Tablet 10pcs

Uses of Servipep 40mg Tablet

Treatment of Stomach ulcers, reflux oesophagitis, and Zollinger-Ellison syndrome

How does Servipep 40mg Tablet work?

It works by blocking the secretion of excess gastric acid thereby reducing the amount of acid in the stomach. 

Side Effects of Servipep 40mg Tablet

• Headache
• Dizziness
• Constipation
• Diarrhea

Quick Suggestions:

• You can take famotidine with or without food, as directed by your doctor.
• If you're also taking other medications to treat acidity, such as antacids, it's recommended to take them at least 2 hours before or after taking famotidine. This helps prevent any potential interactions between the medications.
• Avoid consuming soft drinks and citrus fruits like oranges and lemons, as they can irritate the stomach and increase acid secretion, counteracting the effects of famotidine.
• If you do not experience relief from your symptoms after taking famotidine for 2 weeks, it's important to inform your doctor. Persistent symptoms may indicate underlying issues that need further evaluation and treatment.
• Inform your doctor if you have been diagnosed with kidney disease. Depending on the severity of your condition, the dose of famotidine may need to be adjusted to ensure safety and effectiveness.
• Do not stop taking famotidine abruptly without consulting your doctor. It's important to follow your doctor's instructions regarding the duration of treatment and any tapering off schedule to avoid potential rebound effects or recurrence of symptoms.

Indication of Servipep 40mg Tablet

Servipep is indicated in

• Gastric ulcer
• Duodenal ulcer
• Anastomotic ulcer
• Acute stress ulcer
• Reflux esophagitis and
• Zollinger-Ellison syndrome.

Pharmacology

Famotidine acts as a histamine H2-receptor antagonist, meaning it blocks the action of histamine on H2-receptors located on parietal cells in the stomach. By doing so, famotidine effectively inhibits the secretion of gastric acid in various conditions.

It exerts its inhibitory effects on gastric acid secretion in several ways:

• Basal Inhibition: Famotidine reduces the secretion of gastric acid during periods of rest or fasting, known as basal acid secretion.
• Overnight Inhibition: It continues to suppress gastric acid production during the night when acid secretion is typically higher due to reduced food intake.
• Pentagastrin Stimulation Inhibition: Famotidine also blocks the increase in gastric acid secretion stimulated by pentagastrin, a synthetic hormone that mimics the action of gastrin, a natural hormone that stimulates acid secretion in the stomach.

Additionally, famotidine's binding to H2-receptors is slowly reversible, meaning that it remains bound to the receptors for an extended period before dissociating. This slow dissociation contributes to its long-lasting effects on reducing gastric acid secretion.

Dosage & Administration of Servipep 40mg Tablet

Gastric ulcer, duodenal ulcer, anastomotic ulcer, upper gastrointestinal hemorrhage, reflux esophagitis, and Zollinger-Ellison syndrome:

• Adults: Famotidine 20 mg twice daily (after breakfast and after supper or before bedtime).
• Alternatively, Famotidine 40 mg can be orally administered once daily at bedtime.

Acute gastritis, chronic gastritis in acute exacerbation stage:

• Adults: Famotidine 20 mg orally twice a day (after breakfast and after supper or before bedtime).
• Alternatively, Famotidine 40 mg can be orally administered once a day before bedtime. Dosage should be adjusted according to age and symptoms.

Maintenance Therapy:

• The recommended oral dose for most ulcer patients for maintenance therapy is 20 mg once daily.
• Dosage adjustments should be made as directed by the registered physician.

Interaction

Drug Interactions:

• Servipep 40mg Tablet may interact with various medications including antacids, antifungal drugs (ketoconazole and itraconazole), medications for hepatitis C (Ledipasvir / Sofosbuvir), leukemia treatments (nilotinib, dasatinib), antibiotic drugs (cefditoren), and HIV medications (rilpivirine, fosamprenavir).
• There can be interactions between Servipep 40mg Tablet and alcohol, potentially increasing the risk of side effects.

Drug-Disease Interactions:

• Use Servipep 40mg Tablet cautiously in patients with gastrointestinal bleeding, lactose intolerance, H. pylori infection, and renal dysfunction.

Contraindications

• Servipep 40mg Tablet is contraindicated in children and breastfeeding mothers.
• Avoid taking Servipep 40mg Tablet if you have a known allergy to famotidine, other H2 receptor antagonists, or any of its ingredients.

Pregnancy & Lactation

Pregnancy category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Caution should be exercised when Famotid is administered to a nursing woman.

Precautions & Warnings

• Inform your doctor about any gastrointestinal problems, Helicobacter pylori infection, lactose intolerance, or kidney diseases before using Servipep 40mg Tablet.
• Notify your doctor if you are pregnant or planning to become pregnant.

Storage Conditions:

Store in a cool and dry place away from sunlight