Sandocal 500mg Tablet 10pcs

✔️ Uses of Sandocal 500mg Tablet

Calcium Deficiency Supplement

✔️ How does Sandocal 500mg Tablet work?

• Calcium carbonate can rapidly and effectively neutralize gastric acid.
• Adverse Effects: Activation of calcium-dependent processes, leading to the secretion of gastric and hydrochloric acid.
• Prolonged high doses may cause hypercalcemia, alkalosis, and milk-alkali syndrome.

✔️ Side Effects of Sandocal 500mg Tablet

• Anorexia, nausea, vomiting, constipation, flatulence.
• Hypercalcaemia, metabolic alkalosis, milk-alkali syndrome, tissue calcification.
• Gastric hypersecretion and acid rebound (with prolonged use).

✔️ Quick Suggestions:

• Calcium carbonate has been extensively studied in children and infants with chronic renal failure and is both safe and effective.
• Constipation may be troublesome in elderly patients with renal failure.
• Calcium-containing drugs have been widely used in pregnancy and lactating women.
• Monitoring of serum calcium and phosphate is indicated for elderly patients.

✔️ Pharmacology

• Calcium carbonate reacts with gastric acid to produce salt and water.
• Postulated chemical reaction for Sandocal 500 mg: CaCO3 + 2HCl = CaCl2 + H2O + CO2.
• An increase in gastric pH diminishes the activity of pepsin in gastric secretion.
• Up to 30% of the oral calcium load may be absorbed.

✔️ Dosage & Administration of Sandocal 500mg Tablet

Administration:

• Timing: This may be taken with or without food.
• Enhanced Absorption: Take with meals for better absorption.
• Diet Consideration: Avoid taking with a large amount of fiber-rich food.

Adult Dose:

• Hyperacidity:
  • Take 1-2 tablets as needed, up to a maximum of 16 tablets per day.
  • Tablets may be sucked or chewed for administration.
• Hyperphosphataemia in Chronic Renal Failure:
  • Initial: 2.5 g/day
  • Up to 17 g/day in divided doses.

Renal Dose:

• Renal impairment (CrCl < 25 ml/min): Dosage adjustments may be needed based on serum calcium levels.

✔️ Interaction

• Co-administration with thiazide diuretics or vitamin D may lead to milk-alkali syndrome and hypercalcaemia.
• Decreased absorption with corticosteroids.
• Decreases absorption of tetracyclines, atenolol, iron, quinolones, alendronate, Na fluoride, Zn, and calcium-channel blockers.
• Enhances cardiac effects of digitalis glycosides and may precipitate digitalis intoxication.

✔️ Contraindications

• Patients with calcium renal calculi or a history of renal calculi.
• Hypercalcaemia.
• Hypophosphataemia.
• Patients with suspected digoxin toxicity.

✔️ Pregnancy & Lactation

• Pregnancy category: C.
• Lactation: Safe; crosses the placenta and appears in breast milk.

✔️ Precautions & Warnings

• Renal impairment.
• Hypoparathyroid disease.
• Hypercalcemia-associated diseases.
• Caution in patients with a history of kidney stones.
• Calcium absorption is impaired in achlorhydria; use an alternate salt and take it with food.
• Lactation: Safe; crosses the placenta and appears in breast milk.

✔️ Storage Conditions

Store in a cool, dry place in controlled room temperature.