Protet-IG 250IU/ml Injection

Uses of Protet-IG 250IU/ml Injection

• Treats and prevents Tetanus Infection

How does Protet-IG 250IU/ml Injection work?

It stimulates the body's immune system to produce an

Side Effects of Protet-IG 250IU/ml Injection

• Injection site reactions: Pain, soreness, tenderness.
• Increased temperature, angioneurotic edema, nephrotic syndrome, anaphylactic shock.

Quick Suggestions:

• Caution in patients with coagulation disorders or thrombocytopenia.
• Not for IV administration.
• Use with caution during pregnancy and lactation.
• If adsorbed tetanus vaccine is used concurrently, administered with separate syringes and into different injection sites with separate lymphatic drainage.
• Observe patients for at least 20 minutes after administration.

Indication of Protet-IG 250IU/ml Injection

• Prophylaxis of post-traumatic tetanus in patients with insufficient or uncertain immunity.
• Therapy in the treatment of tetanus.
• To be used with active tetanus toxoid vaccination unless contraindicated or full vaccination is confirmed.

Pharmacology

• Prevents tetanus toxin from damaging tissue and producing tetanus symptoms.
• Binds to tetanus toxin, interfering with its normal interaction with human tissues.
• Prevents toxins from entering the nervous system, preventing painful muscle spasms and autonomic dysfunction.
• Clostridium tetani is destroyed by antibiotic treatment, and immunoglobulin disrupts the immunoglobulin-binding toxin.

Dosage & Administration of Protet-IG 250IU/ml Injection

Adult Dose:

• Post-exposure prophylaxis of tetanus: Single dose of 250 IU; may increase to 500 IU in specific cases.
• Therapy of clinically manifest tetanus: Single doses of 3,000 to 6,000 IU (combined with appropriate clinical procedures).

Child Dose:

• Post-exposure prophylaxis of tetanus: Single dose of 250 IU; may increase to 500 IU in specific cases.
• Therapy of clinically manifest tetanus: Single doses of 3,000 to 6,000 IU (combined with appropriate clinical procedures).

Administration:

• Intramuscular injection only; avoid intravenous administration.
• Use at body temperature; do not use cloudy or sedimentary solutions.
• Administer in divided doses at different sites if a relatively large total volume is required.
• Co-administration with vaccines may alter vaccine efficacy.

Interaction

Drug Interactions:

• Certain medicines may interact with tetanus immune globulin.
• Inform your doctor about all medicines you are taking, including vaccines.
• Interactions may increase the risk of side effects.

Other Interactions:

• Discuss with your healthcare professional the use of this medicine with food, alcohol, or tobacco.

Contraindications

• Hypersensitivity to any component of the product.
• Known hypersensitivity to human immunoglobulin.
• Not recommended in patients with bleeding disorders or a history of immunoglobulin A (IgA) deficiency.

Pregnancy & Lactation

Safety during pregnancy is not established; long-term clinical experience suggests no harmful effects.

Precautions & Warnings

• Intravenous administration is not recommended.
• Use separate sterile syringes for each patient to avoid disease transmission.
• Caution in people with systemic allergy to immunoglobulins; have epinephrine available.
• Administer cautiously in severe thrombocytopenia or coagulopathy contraindicated for intramuscular administration.
• Withdraw the syringe plunger before injection to ensure the needle is not lodged in a blood vessel.
• Prepared from pasteurized plasma to reduce viral infection risk, but some risks remain.

Storage Conditions

• Store between +2°C and +8°C; do not freeze.
• Discard if frozen; avoid light.