Microgest 200mg 10pcs

Indications of Microgest 200

Progesterone, a female sex hormone, makes up Microgest 200. It is used to address problems with menstruation and pregnancy brought on by hormonal imbalance. In order to avoid endometrial hyperplasia, it is also recommended in conjunction with estrogen as part of hormone replacement therapy (thickening of the lining of the uterus).

• Maintenance of Pregnancy in cases of Threatened / Recurrent abortion.
• Luteal support during IUI and ART procedures IVF-ET.
• Along with estrogen in post-menopausal hormone replacement therapy (HRT) either in sequential or in a continuous regimen.
• Luteal support in cases of proven luteal phase insufficiency.
• For cycle control along with estrogen therapy.
• As progesterone challenge test in secondary amenorrhoea.
• To prevent endometrial hyperplasia where endogenous estrogen is present.
• Benign mastopathy.
• Premenstrual tension.
• Dysfunctional uterine bleeding (DUB)
• Oocyte donation program.
•  Endometriosis

Pharmacology

Progesterone softgel capsule contains micronised progesterone, which is structurally and biologically identical to natural endogenous progesterone. Micronisation increases the bioavailability of progesterone. When micronised progesterone is administered after meals, maximal serum progesterone levels are significantly increased. Progesterone concentrations in the endometrial and breast tissue attain high level. Progesterone is approximately 96%-99% bound to serum proteins, primarily to serum albumin (50%-54%). Progesterone is metabolized to pregnanediols and pregnanolones in the liver. The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the bile and urine. Progesterone metabolites, which are excreted in bile, may undergo enterohepatic circulation.

Dosage & Administration of Microgest 200

The usual recommended dose: Microgest® 100mg/200mg 2 to 3 softgel capsules daily by the
oral or vaginal routes in divided doses. Flexible dosage regimen can be followed depending on
the indication and requirements of patients.
• Maintenance of Pregnancy in cases of Threatened / Recurrent abortion: Microgest® 200 to
400 mg per day in divided doses.
• In-vitro fertilization and embryo transfer : Microgest® 200mg thrice a day from the day of
embryo transfer till pregnancy is confirmed. If pregnant, it is continued till 12th week of pregnancy.
• HRT : In sequential regimen: Microgest® 200mg daily for 12 days in last 2 weeks of each
therapeutic cycle. In continuous regimen: Microgest® 100 mg daily throughout the month along
with estrogen.
• Oocyte donation programme : Microgest® 100mg twice daily from the day of transfer till
pregnancy is confirmed. This may be increased to a maximum of 600 mg per day and continued
till 12th week of pregnancy.
• Luteal support : Microgest® 100mg thrice a day from the 17th day of the cycle for 10 days in
induced cycle. If pregnant, it is continued till 12th week of pregnancy.
• Luteal phase insufficiency: Microgest® 100mg thrice daily to be continued up to 12 weeks of
pregnancy, increasing the dose by 100mg/day/week to a maximum of 600mg/day in divided doses
if required.
• In secondary amenorrhoea: Microgest® 300mg for 10 days results in withdrawal bleeding in
80% of cases.
• Premenstrual syndrome: Microgest® 100-200mg daily for 10 days from 17th to 26th day of each
menstrual cycle.
• Benign mastopathy: Microgest® 200-300 mg for 10 days per month, usually from 17th to 26th
day of the monthly cycle.

Interaction of Microgest 200

Ketoconazole inhibits the metabolism of progesterone.

Contraindications

Hypersensitivity, hepatic dysfunction, undiagnosed vaginal bleeding, porphyria, cancers of uterus and genital organs, breast cancers, history of stroke or blood clots. It should not be used in a case of miscarriage and tissue left in the uterus.

Side Effects of Microgest 200

Progesterone is devoid of estrogenic, androgenic and mineralocorticoid effects. Mild somnolence and other CNS side effects like depression, breast tenderness and bloating are reported. Side effects are less when vaginal route is used.

Pregnancy & Lactation

Contact the specialist some time recently utilizing MICROGEST 200MG CAPSULE. Your specialist will choose whether MICROGEST 200MG CAPSULE ought to be given to the pregnant lady or not depending on her condition.

Precautions & Warnings

Severe renal insufficiency, diabetes mellitus, seizures, migraine, headache, heart diseases, depression.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.