Indomethacin is available for oral administration as a 25 mg capsule and as a rectal suppository containing 100 mg of indomethacin.
The recommended dosage of Indomethacin is 50 mg to 200 mg daily in divided doses and should be individually adjusted to the patient’s response and tolerance. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Unlike some other potent antirheumatic agents, an initial high “loading” dose of Indomethacin is not necessary. In chronic rheumatic disorders, initiating therapy with low doses, increasing gradually when necessary, and continuing for an adequate period (up to one month is recommended) will produce maximum benefit and minimise adverse reactions.
In patients with persistent night pain and/or morning stiffness, a dose of up to 100 mg at bedtime may be helpful in affording relief. It is rarely necessary to exceed a dosage of 200 mg per day.
In the treatment of acute gouty arthritis, the recommended daily dosage is 150 mg to 200 mg until all symptoms and signs subside.
In primary dysmenorrhoea, the recommended dosage is 25 mg three times a day starting with onset of cramps or bleeding and continuing for as long as the symptoms usually last.