Flamyd 500mg Tablet (100pcs Box)

Uses of Flamyd 500mg Tablet

• Bacterial infections
• Parasitic infections

How does Flamyd 500mg Tablet work?

Flamyd 500mg Tablet is a protozoal inhibitor. It functions by eliminating the parasites and bacteria that lead to illnesses in the body. As a consequence, it eliminates the infection-causing microorganisms and stops their development and multiplication, lessening the infection's severity.

Side Effects of Flamyd 500mg Tablet

• Metallic taste
• Nausea,
• Vomiting
• Agitation
• Blurred vision
• Burning or tingling sensation of hands and feet
• Confusion
• Dizziness
• Headache
• Nasal congestion
• Skin Rash
• Bleeding gums
• Constipation
• Dark urine
• Fast heartbeat
• Stomach ache
• Metallic taste
• Diarrhea
• Drowsiness
• Rashes may be observed during treatment.

Quick Suggestions:

• Flamyd 500mg Tablet is a medication used to treat infections caused by bacteria and parasites. While it can be effective, there are potential side effects that may occur. Common side effects include nausea, stomach upset, and a metallic taste in the mouth.
• It's important to take Flamyd 500 only as prescribed by your doctor and to follow the recommended dosage and duration of treatment. Using it in high doses or for a prolonged period of time can increase the risk of side effects, including nerve damage. Therefore, it's crucial to adhere to your doctor's instructions.
• During treatment with Flamyd 500, it's advised to avoid consuming alcohol. Drinking alcohol during or for 2-3 days after treatment can lead to symptoms such as nausea, vomiting, flushing, and headaches.
• If you have liver disease, it's important to inform your doctor, as the dose of Flamyd 500 may need to be adjusted in cases of severe liver disease.
• After completing a full course of Flamyd 500, it is recommended to take probiotics to restore healthy bacteria in the intestine that may have been affected by the medication. Probiotics can help reduce the risk of antibiotic-associated diarrhea. Foods like yogurt, cheese, sauerkraut, and kimchi that contain beneficial bacteria can also be helpful in restoring the balance of good bacteria in the intestines.
• Including fiber-enriched foods in your diet can also support the growth of gut bacteria. Whole grains like whole-grain bread and brown rice are examples of fiber-rich foods that can be beneficial.
• It's important to avoid consuming alcoholic beverages while taking Flamyd 500, as alcohol can lead to dehydration and affect your sleep. This can potentially hinder the body's ability to fight off infections.
• If you experience diarrhea while taking Flamyd 500, make sure to drink enough fluids to prevent dehydration.

Indication of Flamyd 500mg Tablet

It is used to treat various bacterial and parasitic infections in the body such as:

• Amoebiasis and Giardiasis (a parasitic infection causing severe diarrhea with stomach cramps)
• Infection of the genital or urinary tract (such as trichomonas vaginitis)
• Blood infections
• Brain infections (such as meningitis)
• Lung infections
• Stomach infections (Ex. H. pylori infection)
• Infection of the pelvic area
• Gum and teeth infection
• Infected leg ulcers or pressure sores

It also helps in preventing post-surgical infections and infections following childbirth.

Pharmacology

Metronidazole is an antibacterial and antiprotozoal medication that belongs to the imidazole family. It is effective against anaerobic bacteria and certain protozoa.

Metronidazole undergoes metabolic reduction in anaerobic organisms, where the 5-nitro group of the drug is reduced. The reduced form of metronidazole interacts with DNA in bacterial cells, leading to the disruption of DNA synthesis and ultimately causing cell death. This bactericidal effect contributes to the antimicrobial activity of metronidazole against anaerobic bacteria.

In addition to its bactericidal properties, metronidazole also exhibits antiprotozoal activity. It is thought to disrupt the DNA of protozoa, inhibiting their growth and replication.

Overall, metronidazole's mechanism of action involves its reduction by anaerobic organisms and subsequent interaction with DNA, leading to the inhibition of bacterial and protozoal growth and the elimination of the infection.

Dosage and Administration of Flamyd 500mg Tablet

Adult Dose:

• For amoebiasis (intestinal infection): Take 800 mg three times a day for 5 days. The maximum daily dose is 2.4 g.
• For amoebiasis (extra-intestinal infection): Take 800 mg three times a day for 5-10 days. The maximum daily dose is 2.4 g.
• For trichomoniasis: Take 2 g as a single dose, or 200 mg three times a day for 7 days, or 400 mg twice a day for 5-7 days. Sexual partners should also be treated. Repeat treatment if necessary after 4-6 weeks.
• For giardiasis: Take 2 g once daily for 3 days, or 400 mg three times a day for 5 days, or 500 mg twice a day for 7-10 days.
• For bacterial vaginosis: Take 2 g as a single dose, or 400 mg twice a day for 5-7 days.
• For acute necrotizing ulcerative gingivitis: Take 200 mg three times a day for 3 days.
• For anaerobic bacterial infections: Initially, take 800 mg followed by 400 mg every 8 hours, or alternatively, take 7.5 mg/kg every 6-8 hours. The maximum daily dose is 4 g. The duration of treatment is usually 7 days depending on the severity of the infection.
• For prophylaxis of postoperative anaerobic bacterial infections: Take 400 mg every 8 hours, starting 24 hours before surgery, and switch to oral therapy when possible.
• For eradication of H. pylori associated with peptic ulcer disease: Take 400 mg twice a day in combination with other antibacterial agents and a proton pump inhibitor (PPI), or take 400 mg three times a day if given with omeprazole and amoxicillin. The initial treatment is given for 1 week.
• For leg ulcers and pressure sores: Take 400 mg three times a day for 7 days.
• For acute dental infections: Take 200 mg three times a day for 3-7 days.

Child Dose:

• For amoebiasis: Children aged 1-3 years should take 100-200 mg three times a day, children aged >3-7 years should take 100-200 mg four times daily, and children aged >7-10 years should take 200-400 mg three times a day. The duration of treatment is 5-10 days.
• For trichomoniasis: Children aged 1-10 years should take 40 mg/kg as a single dose or 15-30 mg/kg daily in 2-3 divided doses for 7 days. The maximum dose is 2 g.
• For giardiasis: Children aged 1-3 years should take 500 mg once daily, children aged >3-7 years should take 600-800 mg once daily, and children aged >7-10 years should take 1 g once daily. The duration of treatment is 3 days.
• For acute necrotizing ulcerative gingivitis: Children aged 1-3 years should take 50 mg three times a day, children aged >3-7 years should take 100 mg twice a day, and children aged >7-10 years should take 100 mg three times a day. The duration of treatment is 3 days.
• For anaerobic bacterial infections: Infants younger than 8 weeks should take 7.5 mg/kg every 12 hours

Interaction

• When metronidazole is used in conjunction with disulfiram (a medication used in the treatment of alcoholism), it may lead to psychotic responses. Therefore, caution should be exercised when using these medications together.
• Metronidazole can enhance the effects of oral anticoagulants (medications that prevent blood clotting), potentially increasing the risk of bleeding. Close monitoring of coagulation parameters is advised when these medications are used concurrently.
• There is a risk that metronidazole may increase the likelihood of lithium poisoning. Patients taking lithium should be closely monitored for signs of lithium toxicity if metronidazole is prescribed.
• When metronidazole is used along with 5-fluorouracil (a chemotherapy medication), it can reduce the renal clearance of 5-fluorouracil, potentially leading to increased toxicity. Careful monitoring for adverse effects is necessary when using these medications together.
• Coadministration of metronidazole and ciclosporin (an immunosuppressive medication) may result in elevated levels of ciclosporin in the blood. Regular monitoring of ciclosporin levels and adjustment of the dosage may be required.
• The use of metronidazole with busulfan (a chemotherapy medication) can cause a significant increase in busulfan plasma levels, leading to severe toxicity. Caution should be exercised, and close monitoring of busulfan levels and patient response is essential in such cases.
• Phenobarbital and phenytoin are medications used for epilepsy and seizures. When used concomitantly with metronidazole, they can enhance the metabolism of metronidazole, resulting in reduced serum concentrations. Monitoring of metronidazole levels and adjustment of the dosage may be necessary in patients using these medications together.

Contraindications

Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.

Pregnancy & Lactation

Metronidazole is classified as a pregnancy category B by the US Food and Drug Administration. However, no appropriate and well-controlled trials in pregnant women have been conducted. Because animal reproduction studies do not always anticipate a human response, this medication should only be taken during pregnancy if absolutely necessary. Human milk has been found to contain metronidazole. When Metronidazole is given to a breastfeeding mother, care should be used.

Precautions & Warnings

• If metronidazole needs to be administered for a longer duration than the usually recommended period, it is important to closely monitor patients and conduct regular hematological tests, especially leucocyte counts. This is to keep a check on any potential adverse reactions, such as peripheral or central neuropathy, which can manifest as symptoms like tingling or numbness (paresthesia), difficulty with coordination (ataxia), dizziness, or even convulsive seizures.
• It is crucial to inform your doctor if you have liver disease, as the dose of metronidazole may need to be adjusted in cases of severe liver impairment.
• For patients with hepatic encephalopathy (a condition characterized by brain dysfunction due to liver disease), metronidazole should be used with caution.
• One notable side effect of metronidazole is its potential to cause discoloration of urine. Patients should be informed about this possibility so that they are not alarmed if they notice changes in the color of their urine while taking the medication.

Storage Conditions

Keep it below 30°C. Protect yourself from the sun. Medicines should be kept out of the reach of youngsters. Do not use it beyond the expiration date.