Enigma 50mg Tablet

Uses of Enigma 50mg Tablet

• Treatment of Erectile Dysfunction

How does

Erection in humans is an involuntary process controlled by the autonomic nervous system. When stimulated, two crucial components of the penis, the corpus cavernosum and corpus spongiosum, work together to maintain blood flow and create an erection. Another vital factor in regulating this process is cyclic Guanosine monophosphate (cGMP), which facilitates increased blood flow to the penis, leading to an erection.

In individuals with erectile dysfunction, cGMP-specific Phosphodiesterase type 5 (PDE5) binds to cGMP, inhibiting its action. Sildenafil prevents the degradation of cGMP by PDE5 in the corpus cavernosum. Sildenafil shares a similar structure with cGMP and binds to PDE5, ultimately leading to the preservation of free cGMP and an uninterrupted erection.

Side Effects of

• Headache
• Nosebleed
• Indigestion
• Trouble sleeping
• Diarrhea
• Dizziness
• Bloody and cloudy urine
• Burning, numbness, tingling in the arms and feet
• Visual disturbances
• Sensitivity to light
• Prolonged and painful erection
• Painful urination
• Excessive tearing of the eye
• Ringing or buzzing in the ears
• Deafness
• Nasal congestion
• Nausea
• Redness of the skin especially on the face and neck

Quick Suggestions:

• Take Enigma 50mg Tabletwith or without food but if you have taken a heavy meal, it may take longer to work.
• Do not crush, break, or chew the tablet. Avoid taking it more than once a day. It is not recommended to give your medicine to other people even if their condition appears to be the same as yours.
• It is advisable to take Enigma 50mg Tablet an hour before sexual intercourse. But, you can take it anytime between 30 minutes and 4 hours before sexual activity.
• Seek medical attention if the erection persists for more than 4 hours after sexual intercourse.
• It is important to note that this medicine will not work without sexual stimulation.
• This medicine does not cure erectile dysfunction. Factors such as obesity, smoking, drinking, etc., could also contribute to erectile dysfunction.
• Follow major lifestyle modifications like quitting smoking and drinking, weight management, eating a healthy diet, and exercising along with Enigma 50mg Tablet.
• Remember that Enigma 50mg Tablet does not offer any protection against sexually transmitted diseases (STDs) such as syphilis, gonorrhea, HIV, etc. hence, adequate safety measures should be taken while having sexual intercourse.

What is Erectile Dysfunction?

Erectile Dysfunction, often referred to as ED, is characterized by the inability to achieve or maintain a firm and suitable penile erection for sexual intercourse. This condition can be attributed to various physical or psychological factors, including performance anxiety, depression, low self-esteem, stress, or a fear of sexual inadequacy. Additionally, certain health-related factors such as smoking, excessive alcohol consumption, obesity, physical inactivity, and high blood pressure contribute to the development of erectile dysfunction.

Common symptoms of erectile dysfunction encompass difficulties in attaining an erection, challenges in sustaining the erection during sexual activity, and a decrease in sexual desire.

Pharmacology

Sildenafil is a selective inhibitor of cyclic Guanosine Monophosphate (cGMP)-specific phosphodiesterase se type 5 (PDE5) used for the treatment of erectile dysfunction. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that inhibits the cyclic Guanosine Monophosphate phosphodiesterase (cGMP). It's a medication that's used to treat erectile dysfunction.

Dosage & Administration of Enigma 50mg Tablet

• The recommended dose of Sildenafil is 50 mg taken approximately 1 hour before sexual activity.
• However, Sildenafil may be taken anywhere from half an hour to 4 hours before sexual activity.
• Based on effectiveness and toleration, the dose may be increased to a maximum of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.
• Sildenafil may take a longer time to work if you take it with a heavy meal.

Interaction

Drug-Drug Interactions:

Prior to using Enigma 50mg Tablet, it's crucial to inform your doctor about any ongoing medications, including:

• Nitrates or Amyl Nitrites: These are employed for alleviating chest pain (e.g., nitroglycerin, isosorbide dinitrate).
• Protease Inhibitors: These are utilized in HIV infection treatment (e.g., ritonavir, lopinavir).
• Alpha Blockers: Medications for prostate issues or blood pressure management (e.g., silodosin, doxazosin).
• Riociguat: A drug prescribed for pulmonary hypertension (increased lung pressure).

Drug-Food Interactions:

It's advisable to avoid consuming heavy meals when taking Enigma 50mg Tablet, as it may delay the onset of its effects.

Contraindications

Any component of sildenafil is contraindicated in patients who are hypersensitive to it. Sildenafil enhances the hypotensive effects of nitrates, hence it's not recommended for people who take organic nitrates on a regular or irregular basis.

Pregnancy & Lactation

Adegra is not indicated for use by women. 

Precautions & Warnings

• Hypotension: It can cause a temporary drop in blood pressure, so be cautious when using it alongside other high blood pressure medications.
• Priapism: This tablet might result in priapism, an extended painful erection lasting over 4 hours. Seek immediate medical help if this occurs.
• Loss of Hearing: It has been linked to sudden hearing loss and ringing in the ears. Avoid it if you have hearing issues and consult a doctor if hearing problems arise.
• Surgery: Inform your doctor if you are using Enigma 50mg Tablet before any surgical procedures, as it can significantly lower blood pressure during surgery.
• Use in Children: Not suitable for individuals under 18 years old due to a lack of clinical safety and efficacy data.
• Counseling: Understanding the root cause of erectile dysfunction is crucial. Therapy and counseling can complement the effectiveness of this medication.
• Use in Females: Not recommended for use in women.
• Effect on Vision: Cases of visual disturbances have been reported, especially when used with other PDE5 inhibitors. Discontinue use and contact your doctor if you experience sudden vision loss.
• Effect on Bleeding: Use with caution if you have gastrointestinal bleeding or an active ulcer.
• Ability to Operate Machinery: It typically doesn't severely impair your ability to drive or operate machinery, but be mindful of how it affects you.

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.