Dermovate 0.05% Cream 25gm

Uses of Dermovate 0.05% Cream

Treatment of skin conditions such as Psoriasis

How does Dermovate 0.05% Cream work?

The active ingredient in Dermovate cream is clobetasol propionate, which belongs to the class of medicines known as topical corticosteroids. Corticosteroids work by reducing inflammation in the skin. Inflammation can occur due to various reasons, including allergic reactions or skin irritation. When the immune system releases substances that widen blood vessels in the skin, it leads to redness, swelling, itchiness, and pain, as seen in conditions like dermatitis or eczema.

Side Effects of Dermovate 0.05% Cream

Side effects of Dermovate cream may include an increased risk of opportunistic infections, endocrine disorders (such as Cushing's syndrome), skin atrophy, stretch marks, thinning or wrinkling of the skin, dry skin, changes in skin pigmentation, and itching or local pain/burn.

Quick Suggestions:

• Clobetasol is used to treat redness, swelling, itching, and discomfort of various skin conditions.
• It should be applied to the affected areas as a thin film, two times daily, or as advised by your doctor.
• Do not use it more often or for longer than advised by your doctor.
• Do not cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
• If you think the area of skin you are treating has become infected you should stop using Clobetasol and consult your doctor.
• Consult your doctor if your skin condition has not improved after four weeks of treatment. Do not use it for more than 4 consecutive weeks at a time.

Indication of Dermovate 0.05% Cream

Dermovate cream is indicated for use in adults, the elderly, and children over 12 years old to relieve inflammatory and pruritic symptoms of steroid-responsive skin diseases, including psoriasis (except widespread plaques), intractable persistent dermatitis, flat lichen, discoid lupus erythematosus, and other skin diseases unresponsive to lower potency steroids.

Pharmacology

Dermovate cream acts as an anti-inflammatory agent by inhibiting late-phase allergic reactions, reducing mast cell density, chemotaxis, eosinophil activation, cytokine production, and arachidonic acid metabolism. It can be absorbed systemically through intact skin, and its metabolism and elimination processes are similar to systemic corticosteroids.

Dosage & Administration of Dermovate 0.05% Cream

For adults, the elderly, and children over 12 years old, a thin layer of Dermovate cream should be applied to the affected area 1-2 times daily for up to 4 weeks, then gradually reduced as symptoms improve. The maximum weekly dose should not exceed 50g. It should not be used on children under 12 years old unless directed by a doctor.

Interaction

Dermovate cream may interact with CYP3A4 inhibitors, potentially increasing systemic exposure to corticosteroids. It should be used with caution in pregnant or breastfeeding women, and only if the potential benefit justifies the potential risk to the fetus or infant.

Contraindications

Dermovate cream should not be used in cases of untreated skin infections, rosacea, acne, itching without inflammation, itching around the anus and genital area, inflammation of the skin around the mouth, hypersensitivity to the cream, viral or fungal infections, extensive plaque psoriasis, or in children under 12 years old.

Pregnancy & Lactation

Clobetasol Propionate should be used in pregnant women only if clinically needed, and the benefits outweigh the risks. If you are pregnant, please consult your doctor before using Clobetasol Propionate. 

It should be used in breastfeeding mothers only if the benefits outweigh the risks. If you are breastfeeding, consult your doctor before using Clobetasol Propionate. Take care that the medicine should not come in contact with your infant.

Precautions & Warnings

Patients with a history of local allergy or hypersensitivity to corticosteroids should use Dermovate cream with caution. Cushing's syndrome, secondary to elevated cortisol levels, may occur, especially with increased absorption of topical steroids. Special care should be taken in certain populations, such as children, the elderly, and those with hepatic or renal impairment.

Storage Conditions:

• Dermovate cream should be stored at room temperature, away from sunlight and moist areas.
• Keep it away from children and pets.