Clovate N Cream

Uses of Clovate N Cream

Psoriasis, Eczema, Severe inflammatory skin disorders

Side Effects of

Long-term widespread application or widespread treatment, similar to other topical corticosteroids, may result in sufficient systemic absorption and the symptoms of hypercortisolism. If an occlusive dressing is used, infants and young children are more likely to experience this effect. In particular, when the use of occlusive dressings or skin folds is impacted, intensive and prolonged treatment with highly active corticosteroid preparations can result in local atrophic changes in the skin, such as thinning, stretch marks, and superficial vasodilation. Topical steroids have reportedly been linked to hirsutism and changes in pigmentation.

How does Clovate N Cream work?

Clobetasol is a highly active corticosteroid that has topical anti-inflammatory action brought about partly by vasoconstriction and reduced collagen synthesis. Neomycin is an aminoglycoside antibiotic that binds to ribosomal 30S and 50S subunits of susceptible bacteria, thus inhibiting protein synthesis; it also causes misreading of the genetic codes on the mRNA template. Nystatin works by binding to ergosterol in the cell membrane of fungus resulting in a change in the cell wall permeability and leakage of cellular components.

Quick Suggestions:

• Clovate N Cream must be applied as a thin layer on the affected area as prescribed by your doctor.
• Do not use this medicine more often or for longer than advised by your doctor.
• Before each application, wash the affected area with soap and water and dry well.
• Avoid getting it in the eyes, mouth, or nose. Rinse with cold water if you accidentally get it in these areas.
• Do not cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
• Inform your doctor if the treated skin area does not improve after 2-4 weeks of treatment.

Indication of Clovate N Cream

Clovate N Cream is used to treat resistant dermatoses (skin infections) with secondary bacterial or fungal infection

Pharmacology

A topical corticosteroid with high potency is clobetasol propionate. It functions as a vasoconstrictor, anti-inflammatory, and antipruritic. Through a variety of anti-inflammatory effects, it prevents late-phase allergic reactions. Chemotaxis, eosinophil activation, and mast cell density are all decreased. Additionally, it lessens the production of cytokines and inhibits arachidonic acid metabolism.

Dosage & Administration of Clovate N Cream

The administration instructions for Clovate N Cream  are as follows:

• Apply the cream sparingly to the affected area(s) once or twice daily until improvement occurs.
• It is important to use a thin layer of cream on the affected area(s).
• Therapy should be discontinued when control is achieved. If a longer course of treatment is necessary, it is recommended to review the patient's condition after 4 weeks.
• Treatment should not be continued for more than 7 days without medical supervision.

For adults:

• Apply a thin layer of the cream or ointment onto the affected area(s) 1-2 times daily until improvement occurs.
• It is not recommended to use the cream for more than 7 days without medical supervision.

For children (2 years and older):

• Apply a thin layer of the cream or ointment onto the affected area(s) 1-2 times daily until improvement occurs.
• It is not recommended to use the cream for more than 7 days without medical supervision.

Please note that it is important to follow the instructions provided by your doctor or healthcare professional regarding the specific usage and duration of treatment with Clovate N Cream.

Interaction

After significant systemic absorption, neomycin sulfate can intensify and prolong the respiratory depression caused by neuromuscular blockers. Neomycin sulfate's systemic exposure is anticipated to be minimal when used as directed, and significant drug interactions are highly unlikely. There have been no reports of harmful interactions between nystatin and clobetasol propionate.

Contraindications

The drug is contraindicated in rosacea, acne vulgaris, and perioral dermatitis, primary skin viral infections (for example, herpes simplex, chickenpox), and those who are allergic to the preparation.

Pregnancy & Lactation

There is little data to prove the possible effects of topical neomycin on pregnancy and lactation. However, neomycin present in maternal blood can cross the placenta and, in theory, may pose risks of fetal toxicity, so its use during pregnancy and lactation is not recommended. The safety of clobetasol propionate in nursing mothers has not been established.

Precautions & Warnings

Long-term continuous topical treatment should be avoided as much as possible, especially in infants and children, because adrenal suppression is prone to occur even in the absence of occlusion. If applied to the eyelids, care must be taken to ensure that the preparation does not get into the eyes as it can cause glaucoma. If this medicine gets into your eyes, flush the affected eyes well with plenty of water.

Storage Conditions

Clovate N Cream should be stored at or below room temperature, away from direct heat or sunlight. Do not freeze. Also, keep it away from the reach of pets and children.