Generic Name: Zuclopenthixol decanoate 200mg / ml ampoule: oily Inj.. Manufacturer/Distributor: Lundbeck Lilac
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Clopixol Depot is a prescription medicine used in the treatment of schizophrenia and anxiety disorder. It alters thoughts and elevates the mood, improving the person’s ability to think, feel and behave. Clopixol Depot is given as an injection under the supervision of a healthcare professional and should not be self-administered. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly without talking to your doctor as it may worsen your symptoms. Some common side effects of this injection include dry mouth, abnormality of voluntary movements, urinary retention, constipation, and muscle rigidity. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, and rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine can lead to weight gain, have a healthy balanced diet and exercise regularly. You may also notice some injection sites reactions such as pain, redness, or swelling. However, these are temporary and usually resolve on their own. Please consult your doctor in case these do not subside or bother you. Before taking it, inform your doctor if you are suffering from thyroid or kidney problems, epilepsy, Parkinson's disease, glaucoma, or any heart problems. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly.
Uses of Clopixol Depot
Side effects of Clopixol Depot
Common
Abnormality of voluntary movements
Constipation
Dryness in mouth
The increased prolactin level in blood
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Sleepiness
Tremor
Urinary retention
Weight gain
How to use Clopixol Depot
Your doctor or nurse will give you this medicine. Kindly do not self-administer.
How Clopixol Depot works
Clopixol Depot is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.
Quick Tips
Indication
Administration
Adult Dose
Oral Psychoses Adult: Initially, 20-30 mg daily in divided doses. Usual maintenance dose: 20-50 mg daily. Up to 150 mg daily for severe or resistant cases. Intramuscular Psychoses Adult: As acetate: 50-150 mg via deep IM inj. May repeat, if needed, after 2-3 days. An additional dose 1-2 days after the 1st dose may be required in some patients. Not >4 inj should be given in a max course of 2 wk and the total dose should not exceed 400 mg. Maintenance: May start oral zuclopenthixol HCl 2-3 days after the last acetate inj or begin IM inj of decanoate with the last inj of the acetate. Elderly: As an acetate ester: Dose reduction may be needed. Max: 100 mg/dose. Hepatic impairment: Half of the normal recommended dose. Chronic psychosis Adult: As decanoate ester: Initially, a test dose of 100 mg by deep IM into the upper outer buttock or lateral thigh to access tolerance, followed after at least 1 wk by 200-500 mg or more, repeated at 1-4 wkly intervals according to the response. Max dose: 600 mg wkly. Inj >2 ml to be distributed between 2 inj sites. Elderly: Reduce the dose to ¼ or ½ of the usual initial dose. Hepatic impairment: Dose reduction may be needed.
Renal Dose
Renal impairment: Dose reduction may be needed.
Contraindication
Hypersensitivity. Comatose states e.g. alcohol, barbiturate, and opiate intoxications; porphyria. children.
Mode of Action
Zuclopenthixol has a high affinity for D1 and D2 receptors and ?-adrenoreceptors. It also has slight antihistamine properties and blocks serotonergic properties.
Precaution
Hepatic and renal impairment, heart disease, recent acute MI, arrhythmias, significant bradycardia (<50 beats/min), severe respiratory disease, epilepsy (and conditions at risk of epilepsy, e.g. alcohol withdrawal or brain damage), Parkinson's disease, acute angle glaucoma, prostatic hypertrophy, hypothyroidism, hyperthyroidism, myasthenia gravis, phaeochromocytoma. Patients at risk of stroke and QT interval prolongation. Avoid abrupt withdrawal. The ability to drive a car or operate machinery may be impaired.
Side Effect
Drowsiness, blurred vision, tachycardia, nausea, dizziness, headache, excitement, postural hypotension, hyperprolactinemia, sexual dysfunction, ECG changes (prolongation of QT interval and T wave changes), and hyperthermia. Extrapyramidal symptoms may occur, especially during the early phase of treatment; urinary frequency or incontinence; tardive dyskinesia. Potentially Fatal: Neuroleptic malignant syndrome, blood dyscrasias.
Interaction
Zuclopenthixol may enhance the sedative effects of alcohol and the effects of barbiturates and other CNS depressants. Zuclopenthixol reduces the antihypertensive effect of guanethidine. Concomitant use of metoclopramide and piperazine with zuclopenthixol increases the risk of extrapyramidal symptoms. Increased risk of severe neurotoxicity with lithium and sibutramine. Increased anticholinergic side effects with drugs with anticholinergic properties. Potentially Fatal: Antagonises effect of apomorphine, levodopa, and other dopamine agonists. Increased risk of blood dyscrasias with clozapine. Increased risk of arrhythmias with drugs that prolong QT interval e.g. class Ia and III antiarrhythmics, erythromycin, or cause electrolyte disturbances e.g. thiazide diuretics.
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