Azelast Nasal Spray

Uses of Azelast Nasal Spray

It is used in adults and in children (aged 6 years or older) to treat:

• Allergic rhinitis (nasal congestion, repeated sneezing, and red, watery, or itchy eyes)

How does Azelast Nasal Spray work?

An anti-allergic drug is called Azelast Nasal Spray. It prevents the production of several chemical messengers that trigger allergic reactions, inflammation, and swelling in the nasal passageway (such as histamines, prostaglandins, and leukotrienes). As a result, it delays the onset of allergy symptoms and lessens uncomfortable allergic rhinitis symptoms.

Side Effects of Azelast Nasal Spray

• Bitter taste
• Headache, tiredness
• Burning sensation in the nose
• Throat irritation, sore throat
• Nasal bleeding
• Nausea, dry mouth
• Dizziness
• Irritation inside your nose
• Repeated sneezing

Quick Suggestions:

• Avoid deep breathing as it will cause the medication to go back to the throat and make it less effective.
• Do not share the bottle with anyone else so that you do not spread germs.
• Staying hydrated is vital for those with a cough or cold. Drink liquids at room temperature to get relief from a runny nose, cough, and sneezing.
• The immune system is affected by stress and raises the risk of being sick. Do meditation, deep breathing, regular exercise and try progressive muscle relaxation techniques to relieve stress.
• It is advised to avoid contact with known allergens (allergy-causing agents) such as pollen, dust, etc. Certain food items are known to cause allergies to you.
• Maintain personal hygiene and keep your surroundings clean.
• Azelast should be avoided in patients with recent nasal ulcers, nasal surgery, or nasal trauma.

Indication of Azelast Nasal Spray

Azelastine, a substance found in Azelast Nasal Spray, is a member of the antihistamine drug class. Both adults and kids (who are at least 6 years old) who have allergic rhinitis can receive treatment for it.

A person's sensitivity to numerous allergens, such as pollens, dust, mold, or flakes of some animals' skin, can result in allergic rhinitis, often known as hay fever. It can be seasonal or chronic and is frequently characterized by nasal congestion, frequent sneezing, and red, watery, or itchy eyes. It can also cause inflammation of the inner nasal lining.

Pharmacology

Azelastine is a phthalazinone derivative that exhibits antagonist activity at the histamine H1 receptors. This action has been observed in various tissues, animal models, and humans.

Azelastine is typically administered as a racemic mixture, meaning it contains equal amounts of both enantiomers (mirror-image forms). In vitro, studies have shown no significant difference in pharmacological activity between the two enantiomers.

Additionally, the major metabolite of azelastine, called desmethyl azelastine, also exhibits H1-receptor antagonist activity. This means that it acts similarly to azelastine in blocking the effects of histamine at the H1 receptors.

It's important to note that while these pharmacological actions of azelastine and its metabolite are well-documented, the specific details of their mechanisms of action may vary and are still being studied. The information you provided highlights the general understanding of azelastine's pharmacology as an H1 receptor antagonist.

Dosage & Administration of Azelast Nasal Spray

• For the treatment of allergic rhinitis, the recommended dosage of Azelastine Nasal Spray is one or two sprays per nostril, twice daily for adults and patients 12 years and older. Pediatric patients aged 5 to 11 years should use one spray per nostril, twice daily.
• In the case of vasomotor rhinitis, the suggested dosage for adults and patients 12 years and older is two sprays per nostril, twice daily.
• Before using Azelastine Nasal Spray, it is important to prime the bottle by releasing four sprays or until a fine mist appears. If the spray has not been used for three or more days, prime it with two sprays or until a fine mist appears. Avoid spraying the solution into the eyes.
• To administer the spray, gently shake the bottle and remove the dust cap. Hold the spray with your index and middle fingers on either side of the nozzle and your thumb underneath the bottle. Press down until a fine spray appears. If using it for the first time or after a week or more of not using it, press the nasal applicator a few times until a fine mist is released.
• Blow your nose gently to clear the nostrils, then close one nostril and insert the nasal applicator into the other nostril. Tilt your head slightly forward and keep the spray upright. Inhale through your nose while pressing down on the collar of the nasal applicator once to release a spray. Exhale through your mouth. Repeat the steps in the same or another nostril for subsequent doses.
• To clean the nasal spray, it should be washed at least once a week. Remove the dust cap and gently remove the nasal applicator. Wash the applicator and dust cap in warm water, shake off excess water, and allow them to dry in a normal place without applying extra heat. Then, gently push the applicator back onto the top of the bottle and reattach the dust cap.

It's important to note that these dosing recommendations are general guidelines. The actual dosage may vary depending on individual factors, such as the severity of symptoms and the response to treatment. It's always best to follow the specific instructions provided by your doctor or healthcare provider regarding the use and dosage of azelastine nasal spray.

Interaction

It is crucial to exercise caution and consult with a healthcare professional before combining Azelastine nasal spray with alcohol, CNS depressants, cimetidine, or ketoconazole.

Contraindications

Contraindicated in patients with a known touchiness to Azelastine or any of its components.

Pregnancy & Lactation

Utilize in pregnancy: The impacts of Azelastine during pregnancy have not been enough examined. Azelastine ought to be managed amid pregnancy, in the event that the potential advantage legitimizes the potential dangers to the fetus. 

Use in nursing mothers: It isn't known whether Azelastine is excreted in the human drain. Be that as it may, caution ought to be worked out when Azelastine is managed by a nursing mother

Precautions & Warnings

• In clinical trials, there have been reports of lethargy in some patients who have used azelastine nasal spray. Therefore, caution should be exercised when driving a car or operating potentially dangerous machinery while using the spray.
• Additionally, it is recommended to avoid concurrent use of azelastine nasal spray with alcohol or other central nervous system (CNS) depressants. Combining these substances may result in further reductions in alertness and increased impairment of CNS function.

Storage Conditions

Keep out of reach of children. Store in a cool and dry place protected from light. Do not freeze.