Anustat Ointment

Uses of Anustat Ointment

• Anal Fissures
• Hemorrhoids or piles
• After hemorrhoids removal surgery
• Prevention of recurrence of piles following surgery
• Proctitis
• Painful evacuation

How does Anustat Ointment work?

Anustat Ointment is a combination of 4 drugs (Cinchocaine, Hydrocortisone, Neomycin, Esculin)

• Cinchocaine is a local anesthetic that works by preventing or reducing the conduction of nerve impulses near the site of administration. It also has a membrane-stabilizing effect by decreasing the permeability of nerve cells to sodium ions. It is used to relieve severe pain and can also help alleviate sphincter spasms.
• Hydrocortisone is a corticosteroid that exhibits anti-inflammatory and immunosuppressive effects. It works by suppressing the migration of polymorphonuclear leukocytes (a type of white blood cell) and reversing increased capillary permeability. Hydrocortisone is commonly used as an anti-inflammatory and antipruritic agent to reduce itching and inflammation. It may also be used as replacement therapy in cases of adrenocortical insufficiency.
• Neomycin is an aminoglycoside antibiotic that acts by binding to the 30S ribosomal subunits of bacterial ribosomes. This inhibits protein synthesis and can lead to errors in genetic code transcription, ultimately causing bacterial cell death. Neomycin is effective against many gram-negative aerobes and some gram-positive aerobes. It is not active against fungi, viruses, or most anaerobic bacteria. In the context of anorectal lesions, neomycin can help eradicate existing or potential bacterial infections.
• Esculin derived from horse chestnut seeds, is known for its effects on improving skin vasculature. It can help improve the vascular system of the skin and has been used in the management of conditions such as cellulitis.

Side Effects of Anustat Ointment

• Application Site Reactions (Burning Sensation)
• Irritation
• Stinging
• Rash
• Skin sagging
• Itching And Redness
• Severe allergic reaction
• Black or tarry stools
• Itching
• Rectal bleeding
• Rectal Pain

Each gram of ointment contains

• Cinchocaine Hydrochloride BP 5mg
• Hydrocortisone USP 5mg
• Neomycin Sulphate BP equivalent to 10mg
• Neomycin Esculin Sesquihydrate equivalent to 10mg Esculin

Quick Suggestions:

• Eat fiber-rich food and drink plenty of fluids. This helps to keep the stools soft.
• A warm bath helps in easing pain and itching.
• Keep your bottom dry and clean.
• Regular exercise is recommended.
• Avoid or limit alcohol and caffeinated products to prevent constipation.
• Empty your bowels whenever your body tells you to.
• Avoid pushing too hard while pooping as it can cause tissue tearing.
• Include fruits, vegetables, and whole wheat grains in your diet.
• Maintaining good personal hygiene can help prevent anal infections and hemorrhoids. Keep the anal area clean and dry, and consider using gentle wipes or bidets for cleansing.

Indication

This is recommended for-

• Hemorrhoids both internal and external
• hemorrhoidal condition after delivery
• Anal fissures, proctitis, peri-anal eczema, and anal pruritus
• Application after hemorrhoidectomy to reduce pain and discomfort

Pharmacology

• Cinchocaine: Cinchocaine is a local anesthetic that works by preventing or reducing the conduction of nerve impulses near the site of administration. It also has a membrane-stabilizing effect by decreasing the permeability of nerve cells to sodium ions. It is used to relieve severe pain and can also help alleviate sphincter spasms.
• Hydrocortisone: Hydrocortisone is a corticosteroid that exhibits anti-inflammatory and immunosuppressive effects. It works by suppressing the migration of polymorphonuclear leukocytes (a type of white blood cell) and reversing increased capillary permeability. Hydrocortisone is commonly used as an anti-inflammatory and antipruritic agent to reduce itching and inflammation. It may also be used as replacement therapy in cases of adrenocortical insufficiency.
• Neomycin: Neomycin is an aminoglycoside antibiotic that acts by binding to the 30S ribosomal subunits of bacterial ribosomes. This inhibits protein synthesis and can lead to errors in genetic code transcription, ultimately causing bacterial cell death. Neomycin is effective against many gram-negative aerobes and some gram-positive aerobes. It is not active against fungi, viruses, or most anaerobic bacteria. In the context of anorectal lesions, neomycin can help eradicate existing or potential bacterial infections.
• Esculin: Esculin, derived from horse chestnut seeds, is known for its effects on improving skin vasculature. It can help improve the vascular system of the skin and has been used in the management of conditions such as cellulitis.

It's important to note that these components are often combined in specific formulations, such as creams or ointments, for the treatment of anorectal conditions. The combination of these ingredients may provide a synergistic effect and targeted relief for symptoms associated with anal fissures, hemorrhoids, or other related conditions. As always, it is recommended to consult with a healthcare professional for personalized advice and appropriate use of medications.

Dosage & Administration of Anustat Ointment

1. Wash your hands before applying the ointment.
2. Clean the affected area and pat it dry.
3. Take a small amount of the ointment (pea-sized) onto your finger.
4. Gently rub the ointment only on the affected area.
5. If a deeper application is required, attach the plastic nozzle to the tube.
6. Insert the nozzle into the anal canal to the full extent.
7. While slowly withdrawing the nozzle, gently squeeze the tube to release the ointment.
8. Stay in position for about 1-2 minutes to allow the ointment to reach the desired area.
9. Wash your hands and the tube nozzle after application.

It is important to follow these instructions as provided by your healthcare professional or as indicated on the product packaging. If you have any specific concerns or questions about the application process, it is advisable to consult with your doctor or pharmacist for further guidance.

Use in children: Not recommended for children.

Interaction

• it is crucial to inform your doctor about all the medications, vitamins, and herbal supplements you are currently using or planning to use, including over-the-counter products. This information is important to ensure that your doctor can evaluate potential drug interactions and help you prevent or manage any adverse effects.
• Drug interactions can occur when two or more substances interact with each other and affect the way they work in the body. This can lead to altered effectiveness, increased side effects, or other unexpected reactions. By providing a comprehensive list of all the substances you are taking, your doctor can assess the potential interactions and make informed decisions regarding your treatment plan.
• Remember to include prescription medications, over-the-counter drugs, herbal supplements, vitamins, and any other substances you are using. It's also important to inform your doctor about any recent changes in your medication regimen or if you plan to start or stop using any products while using Anustat Ointment or any other medication.
• If you have any concerns or questions about potential drug interactions, it is best to consult with your doctor or pharmacist for personalized advice based on your specific situation. They will be able to provide you with the most accurate and relevant guidance regarding your medications.

Contraindications

Patients allergic to any component of this product are contraindicated.

Pregnancy & Lactation

The safe use of topical corticosteroids during pregnancy has not been fully established.

Precautions & Warnings

• Hydrocortisone: Prolonged use of hydrocortisone should be avoided due to the potential for systemic effects. Adrenal suppression can occur even without obstruction. Prolonged use may also lead to the appearance of skin lines. It is important to follow the prescribed duration and avoid excessive or prolonged use of hydrocortisone. Additionally, hydrocortisone should not be applied to severely damaged skin.
• Neomycin: Neomycin can cause skin irritation. In cases of injured or inflamed skin, absorption of antibiotics like neomycin can occur, potentially having irreversible effects on hearing. It is important to avoid using this preparation on severely damaged skin.
• Precautions: Special caution should be taken in the following cases: elderly patients, debilitated patients, children, individuals with epilepsy, impaired cardiac conduction or respiratory function, shock, hepatic impairment, and myasthenia gravis. These conditions may require specific considerations or dose adjustments when using the medication.
• Eye contact: Avoid rubbing or touching the eye while the anesthesia effect of the medication persists. Take care to prevent direct contact with the eyes.
• Pregnancy and lactation: It is advisable to consult with a healthcare professional regarding the use of the medication during pregnancy and lactation to evaluate the potential risks and benefits.
• Practice safe vaginal sex: Taking precautions during sexual activities can reduce the risk of anal infections and related complications. Using condoms and practicing safe sex can help prevent the transmission of sexually transmitted infections.
• Follow a fiber-rich diet: Consuming a diet high in fiber can promote regular bowel movements and prevent constipation, which is a common cause of hemorrhoids. Include whole-grain foods, fruits, vegetables, pulses, whole-wheat bread, and pasta in your diet.
• Limit alcohol and caffeine: Excessive alcohol and caffeine consumption can disrupt normal bowel movements. Limiting or avoiding these substances may help maintain regularity and prevent constipation.
• Exercise regularly: Engaging in regular physical activity, such as 30 minutes of exercise per day, can promote overall health and prevent the occurrence of piles. Breaking down your exercise routine into shorter sessions throughout the day can also be effective.
• Avoid smoking: Smoking can impair wound healing and may contribute to the development of piles. Quitting smoking or avoiding exposure to secondhand smoke can be beneficial for your overall health

Storage Conditions

Keep in a cool dry place protected from light. Keep out of reach of children.