Buflex 1000mg Tablet

✔️ Dosage & Administration

Administration:
Take with food to minimize stomach upset. Swallow whole; do not chew or crush.
Follow your physician’s prescribed dose and duration.

Adult Dose:

Osteoarthritis & Rheumatoid Arthritis:

Initial: 1 g orally once daily.

Maintenance: 1–2 g/day in a single or divided dose every 12 hours.

Maximum: 2 g/day.

Elderly: 500 mg once daily may be sufficient; do not exceed 1 g/day.

Pediatric Use: Not recommended for children.

Renal Impairment:

CrCl 30–49 mL/min: Max initial dose 750 mg once daily; may increase to 1.5 g/day.

CrCl <30 mL/min: Max initial dose 500 mg once daily; may increase to 1 g/day.

✔️ Side Effects:

Common:

Nausea, vomiting, indigestion, stomach or epigastric pain

Diarrhea, heartburn, loss of appetite

Less Common (1–10%):

Constipation, dizziness, headache, edema, flatulence, pruritus, tinnitus, rash, fatigue, gastritis, insomnia, somnolence, stomatitis, nervousness

Frequent (>10%):

Diarrhea (14%), dyspepsia (13%), abdominal pain (12%)

Rare but Serious:

GI bleeding, kidney impairment, or severe allergic reactions.

✔️ Interaction

Anticoagulants & Antiplatelets (e.g., warfarin, clopidogrel, aspirin): May increase risk of bleeding.

Corticosteroids & Methotrexate: May elevate risk of GI toxicity and bone marrow suppression.

Fluoroquinolones: May increase seizure risk.

Diuretics & Antihypertensives: Reduced effectiveness.

Cyclosporine: May elevate serum levels.

Alcohol: Enhances gastric mucosal irritation.

✔️ Contraindications

• Hypersensitivity to ibuprofen or other NSAIDs.
• History of aspirin-induced allergy.
• Severe renal impairment.
• Perioperative pain associated with CABG surgery.

Use with caution in peptic ulcer disease, stomatitis, systemic lupus erythematosus, ulcerative colitis, and late pregnancy (may cause premature closure of the ductus arteriosus).

✔️ Storage Condition

Category C: Use only if potential benefits justify potential risks.

Category D (late pregnancy): May cause premature closure of the ductus arteriosus.

Should be used with caution during pregnancy and avoided near term.

✔️ Precautions & Warnings

• Use cautiously in patients with cardiovascular disease, hypertension, or fluid retention.
• Monitor patients with renal or hepatic impairment closely.
• Discontinue use if GI bleeding or ulceration occurs.
• Avoid long-term use unless advised by a doctor.
• May cause drowsiness or dizziness — use caution when driving or operating machinery.
• Avoid alcohol while taking this medication to reduce stomach irritation risk.
• Regular monitoring of renal, liver, and blood parameters is recommended during prolonged therapy.