Ipralin (0.5mg+2.5mg/3ml) Nebuliser Solution 10pcs

✔️ Ipralin is used for:

• Reversible bronchospasm associated with obstructive airway diseases
• Airway obstruction where treatment with both a beta2-agonist and an anticholinergic bronchodilator is required

It should be used according to the diagnosis and treatment plan provided by a healthcare professional.

✔️ Overdose

Overdose is expected to produce effects primarily related to salbutamol, as systemic absorption of inhaled ipratropium is relatively low.

Possible symptoms include:

• Rapid heartbeat
• Palpitations
• Tremor
• Flushing
• Changes in blood pressure
• Chest or anginal pain
• Cardiac arrhythmias
• Widening of pulse pressure
• Hypokalemia

✔️ Side Effects

• Fine tremor
• Nervousness
• Headache
• Dizziness
• Palpitations
• Increased heart rate
• Dry mouth
• Hoarseness or dysphonia
• Cough
• Throat irritation
• Nausea
• Vomiting
• Sweating
• Weakness
• Muscle cramps or myalgia

✔️ Ipralin should not be used in patients with:

• Known hypersensitivity to ipratropium bromide, atropine, or atropine-like compounds, salbutamol, or any other component of the formulation
• Hypertrophic obstructive cardiomyopathy or certain significant tachyarrhythmias, where the product is contraindicated according to the prescribing information

✔️ Dosage & Administration

Ipralin Nebuliser Solution should be administered using a suitable nebulizer or, when appropriate, an intermittent positive-pressure ventilator.

Adults and Elderly

The usual dose is:

One 3 mL ampoule, administered by nebulization up to four times daily.

If necessary, additional treatments may be prescribed by a doctor. Do not exceed the prescribed frequency without medical advice.

Children

The dose and frequency for children should be determined by a doctor according to the child's age, weight, severity of airway obstruction, and clinical condition.

If breathing difficulty becomes acute or rapidly worsens and additional inhalations do not provide adequate relief, seek immediate medical attention.

✔️ Pregnancy & Lactation

Pregnancy: Adequate controlled human studies are limited. Ipralin should be used during pregnancy only when the expected benefit to the mother outweighs potential risks to the fetus. Salbutamol may inhibit uterine contractions, so particular caution may be required near delivery.

Breastfeeding: It is not fully established whether clinically significant amounts of salbutamol or ipratropium are excreted into human milk. Because many medicines can enter breast milk, Ipralin should be used during breastfeeding only after consultation with a healthcare professional.

✔️ Use Ipralin with caution in patients with:

• Cardiovascular disease or cardiac arrhythmias
• Hypertension
• Diabetes mellitus
• Hyperthyroidism
• Glaucoma or increased intraocular pressure
• Difficulty passing urine or prostatic enlargement
• A history of sensitivity to beta-agonists or anticholinergic medicines

✔️ Drug Interactions

Ipralin may interact with several medicines and may increase the risk of adverse effects when used together with certain drugs.

• Other beta-agonists: May increase beta-adrenergic adverse effects.
• Systemically absorbed anticholinergics: May increase anticholinergic effects.
• Xanthine derivatives: May increase the risk of hypokalemia and other adverse effects.
• Corticosteroids: May contribute to beta-agonist-associated potassium reduction.
• Diuretics: May increase the risk of hypokalemia.
• Digoxin: Low potassium levels may increase susceptibility to cardiac arrhythmias.
• Beta-blockers: May reduce or antagonize the bronchodilating effect of salbutamol and may worsen bronchospasm in susceptible patients.
• MAO inhibitors and tricyclic antidepressants: May enhance the cardiovascular effects of beta-adrenergic agonists.
• Halogenated hydrocarbon anesthetics: Agents such as halothane, trichloroethylene, and enflurane may increase susceptibility to cardiovascular effects from beta-agonists.

✔️ Storage:

• Store below 30°C.
• Protect from light and moisture.
• Keep away from excessive heat.
• Keep out of reach and sight of children.
• Use the ampoule according to the manufacturer's instructions and do not use damaged or improperly stored ampoules.