Ultrapime 1gm IM/IV Injection

✔️ What Ultrapime Treats

Ultrapime is used for treating infections caused by susceptible bacteria, including:

• Skin and soft tissue infections
• Urinary tract infections (UTIs) — uncomplicated and complicated
• Hospital-acquired pneumonia, including multidrug-resistant strains
• Intra-abdominal infections
• Febrile neutropenia
• Sepsis (blood infections)
• Respiratory tract infections in critically ill patients

🩺 To be used strictly under medical supervision.

✔️ Possible Side Effects

• Rash, itching, nausea, vomiting
• Headache, fever, diarrhea
• Injection site reactions (pain, redness)
• Seizures, encephalopathy, hallucinations
• Anaphylaxis, agranulocytosis, thrombocytopenia
• Coma or neuromuscular hyperexcitability (in renal impairment)

✔️ Dosage & Administration

🧍 Adult Dosing

• UTIs: 0.5–1 g every 12 hours for 7–10 days
• Pneumonia (Moderate to Severe): 1–2 g every 12 hours for 10 days
• Complicated abdominal infections: 2 g every 12 hours
• Febrile neutropenia (empiric therapy): 2 g every 8 hours until resolution
• Skin and soft tissue infections: 2 g every 12 hours for 10 days

🧒 Pediatric Dosing

2 months to 16 years

<40 kg: 50 mg/kg every 8–12 hours

40 kg: Use adult dosage

Febrile neutropenia: 50 mg/kg every 8 hours

Given IV over 30 minutes or by IM injection in less severe cases

📌 Renal Dose Adjustments

Dose adjustments are required in renal impairment:

CrCl <10 mL/min: 0.25–0.5 g every 24 hours

CrCl 11–29 mL/min: 0.5–1 g every 24 hours

CrCl 30–60 mL/min: 0.5–2 g every 24 hours

Hemodialysis: 1 g initially, then 0.5 g every 24 hours after dialysis

CAPD: 48-hourly dosing

✔️ 💧 Reconstitution & Administration

IV Infusion

• Reconstitute 500 mg/1 g/2 g vial with 5–10 mL compatible IV fluid
• Further dilute and infuse over 30 minutes

IM Injection

• Reconstitute 500 mg or 1 g with 1.3 mL or 2.4 mL sterile water or 0.9% NaCl
• Inject deeply into the muscle (use only for mild to moderate UTI)

💡 Avoid self-administration. Always follow trained medical personnel guidance.

✔️ Contraindications

Known hypersensitivity to cefepime or other cephalosporins

✔️ Drug Interactions

Aminoglycosides: Increases risk of nephrotoxicity, ototoxicity

Loop diuretics (e.g., furosemide): Heightens nephrotoxicity risk

May reduce prothrombin activity with prolonged use

✔️ Pregnancy & Lactation

Pregnancy Category B: No adequate studies in humans; use only if needed

Breastfeeding: Drug enters milk; use with caution

✔️ Precautions & Warnings

• Use with caution in patients with renal impairment, seizure disorders, or GI disease (e.g., colitis)
• May cause Clostridium difficile-associated diarrhea
• Risk of superinfection with prolonged use
• Monitor prothrombin time in malnourished, hepatic/renal-impaired, or prolonged therapy patients
• Use caution in pregnancy (Category B) and lactation – drug enters breast milk

✔️ Storage:

• Store vials in a cool, dry place below 30°C
• Protect from light and moisture
• Keep out of reach of children