Lizox 400 Tablet

✔️ Words of Advice:

• Lizox 400 is used for certain serious bacterial infections and does not work against viral infections such as common cold or flu.
• Take every dose as prescribed and complete the full course of treatment.
• Diarrhea can occur during treatment. Contact your doctor if diarrhea is severe, persistent, or contains blood.
• Avoid excessive amounts of foods and drinks containing high levels of tyramine, including aged cheese, cured or smoked meats, fermented foods, and certain alcoholic beverages.
• Inform your doctor if you experience unusual bruising, bleeding, persistent fever, severe weakness, vision changes, numbness, or tingling.
• Tell your doctor if you develop symptoms suggestive of low blood sugar, particularly if you use insulin or oral antidiabetic medicines.
• Do not use linezolid for longer than prescribed. Prolonged treatment requires appropriate medical monitoring.

✔️ Adult Dose

Uncomplicated skin and skin-structure infections:
400 mg orally every 12 hours for 10–14 days.

MRSA infections:
600 mg orally every 12 hours for 7–21 days.

Community-acquired pneumonia:
600 mg orally every 12 hours for 10–14 days.

Nosocomial pneumonia:
600 mg orally every 12 hours for 10–14 days.

Complicated skin and skin-structure infections:
600 mg orally every 12 hours for 10–14 days.

Vancomycin-resistant Enterococcus faecium infection:
600 mg orally every 12 hours for 14–28 days.

Elderly patients:
No routine dosage adjustment is generally required solely because of age.

✔️ Lizox 400 should not be used in patients with:

• Known hypersensitivity to linezolid or any component of the formulation.
• Current treatment with monoamine oxidase inhibitors (MAOIs) or use of an MAOI within the previous 2 weeks.
• Certain conditions in which linezolid's monoamine oxidase inhibition may create a significant risk, including uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, or carcinoid syndrome, unless specifically managed by a physician.
• Concomitant use of certain sympathomimetic, vasopressor, dopaminergic, or serotonergic medicines where the combination is considered unsafe.

✔️ How to Use Lizox 400

• Take the medicine exactly according to the dose and duration prescribed by your doctor.
• Swallow the tablet whole with water. Do not crush, chew, or break it.
• It can be taken with or without food.
• Taking it at a fixed time each day may help maintain consistent drug levels and make it easier to remember your doses.
• Complete the entire prescribed course, even if you start feeling better.
• Avoid excessive consumption of tyramine-rich foods, such as aged cheese, smoked or processed meats, fermented foods, and certain alcoholic beverages, as large amounts may increase blood pressure while taking linezolid.

✔️ Child Dose

Dosage in children should be determined according to age, body weight, infection, and the prescribing physician's instructions.

Pneumonia, complicated skin infections, and VRE infections:

• Birth to 11 years: 10 mg/kg every 8 hours
• 12 years and above: 600 mg every 12 hours

Uncomplicated skin and skin-structure infections:

• Birth to 5 years: 10 mg/kg every 8 hours
• 5 to 11 years: 10 mg/kg every 12 hours
• 12 to 18 years: 600 mg every 12 hours

✔️ Hepatic Dose

No routine dose adjustment is generally required for mild to moderate hepatic impairment. Use in severe hepatic impairment should be determined carefully by the treating physician.

✔️ Renal Dose

Routine dosage adjustment is generally not required in patients with renal impairment. However, patients with significant renal dysfunction require appropriate clinical monitoring.

In patients receiving hemodialysis, linezolid is generally administered after the dialysis session when appropriate.

✔️ Use linezolid cautiously in patients with:

• Pre-existing or recurrent myelosuppression
• Significant renal impairment
• Uncontrolled hypertension
• Pheochromocytoma
• Carcinoid syndrome
• Untreated hyperthyroidism
• A history of seizures
• Chronic or prolonged infections requiring extended treatment
• A history of bipolar disorder, schizophrenia, or acute confusional states
• Conditions requiring serotonergic or sympathomimetic medicines

A complete blood count (CBC) should be monitored regularly, particularly during prolonged therapy and in patients at increased risk of myelosuppression.

Longer treatment courses may increase the risk of anemia, thrombocytopenia, leukopenia, pancytopenia, peripheral neuropathy, and optic neuropathy. Report unexplained bruising, bleeding, weakness, numbness, tingling, or visual changes promptly.

✔️ Pregnancy & Lactation

If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using Lizox 400. The medicine should be used during pregnancy or lactation only when the potential benefits justify the potential risks and under medical supervision.

✔️ Linezolid can interact with several medicines:

Rifampicin and phenytoin:
May alter linezolid exposure and potentially reduce its effectiveness.

Insulin and oral antidiabetic medicines:
Linezolid may increase the risk of hypoglycemia in patients receiving diabetes treatment. Blood glucose should be monitored appropriately.

Tramadol:
Concurrent use may increase the risk of seizures and serotonergic adverse effects.

Antidepressants and other serotonergic medicines:
Combining linezolid with MAOIs, TCAs, SNRIs, and other serotonergic medicines may increase the risk of serotonin syndrome. Examples include certain medicines such as bupropion, vilazodone, mirtazapine, buspirone, trazodone, nefazodone, and meperidine.

Sympathomimetic and vasopressor medicines:
Medicines such as pseudoephedrine, epinephrine, norepinephrine, dopamine, and dobutamine may cause a significant increase in blood pressure when combined with linezolid.

Always provide your doctor with a complete list of prescription medicines, over-the-counter products, and supplements before starting Lizox 400.

✔️ Side Effects:

Common:

• Diarrhea
• Nausea
• Vomiting
• Headache
• Dizziness
• Abdominal discomfort or pain
• Rash
• Taste alteration

Other reported effects:

• Anemia
• Thrombocytopenia
• Abnormal liver-function tests
• Vaginal or oral candidiasis
• Fungal infections
• Pruritus
• Vertigo
• Tongue discoloration

Rare but serious effects:

• Myelosuppression
• Lactic acidosis
• Peripheral neuropathy
• Optic neuropathy
• Serotonin syndrome
• Severe allergic or skin reactions, including Stevens-Johnson syndrome
• Renal impairment
• Thrombotic or ischemic events

✔️ Storage:

• Store in a cool, dry place.
• Keep away from excessive heat, moisture, and direct light.
• Keep out of reach of children.
• Use only before the expiry date printed on the package