Fibril 300mg Capsule 1 Strip

✔️ Fibril contains Gemfibrozil, a lipid-regulating agent. It works by:

• Inhibiting the breakdown of fat in fat cells, thus decreasing the flow of fatty acids to the liver.
• It reduces the liver’s production and secretion of very low-density lipoproteins (VLDL), which are rich in triglycerides.
• Increasing HDL (good cholesterol), which helps clear cholesterol from the bloodstream. This action helps to maintain a healthier lipid profile, which is crucial in preventing cardiovascular complications.

✔️ Side Effects

• Nausea, vomiting
• Abdominal pain, flatulence
• Diarrhea
• Increased liver enzyme levels
• Indigestion (dyspepsia)
• Fatigue, headache, dizziness
• Rare but Serious Side Effects:
• Muscle pain or weakness (potential signs of rhabdomyolysis, especially if taken with statins)
• Visual disturbances
• Liver issues (yellowing of the skin/eyes, dark urine)
• Blood disorders like anemia, leukopenia
• Gallstones (cholelithiasis)
• Skin rash or eczema

✔️ Dosage and Administration:

• The standard adult dosage is 600 mg taken twice daily.
• It is important to take Fibril on an empty stomach, ideally 30 minutes before meals.
• Always follow your doctor’s prescribed dose and duration.

✔️ Words of Advice:

• Even if you feel fine, don’t stop taking the medication unless advised by your doctor.
• Regular monitoring of cholesterol levels and liver function is important during treatment.
• Fibril is most effective when used alongside a comprehensive lifestyle plan, including:
• A low-fat, heart-healthy diet
• Regular physical activity
• Smoking cessation
• Moderation of alcohol intake
• Weight management

✔️ Missed Dose:

If a dose is missed:

Take it as soon as you remember.

However, if it’s almost time for your next scheduled dose, skip the missed dose.

Do not double up to make up for a missed dose.

✔️ Interaction

• May enhance the effect of oral anticoagulants (e.g., warfarin), increasing the risk of bleeding.
• Can increase blood levels of repaglinide (an anti-diabetic drug), leading to hypoglycemia.
• When used with cyclosporine, it may raise the risk of kidney damage.
• Serious interaction risk with HMG-CoA reductase inhibitors (statins)—may cause severe muscle damage (rhabdomyolysis).

✔️ Contraindications:

• Known hypersensitivity to Gemfibrozil or any of the excipients
• Severe liver or kidney dysfunction
• Gallbladder disease
• During pregnancy and breastfeeding
• In children or neonates

✔️ Precautions & Warnings

• Rule out and manage underlying conditions like diabetes or hypothyroidism before starting therapy.
• Use cautiously in patients with renal impairment; monitor kidney function closely.
• Avoid combining with statins due to risk of muscle toxicity.
• Periodic lipid profile assessments are recommended.
• Stop use if there's no significant improvement after 3 months.

✔️ Storage:

• Store at room temperature (20-25°C).
• Protect from direct light and moisture.
• Keep out of reach of children.