Empaglif-M 5/500mg Tablet

✔️ Composition | Empaglif-M 5/500

Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It reduces glucose reabsorption in the kidneys, allowing excess glucose to be eliminated through urine.

Metformin hydrochloride is a biguanide antidiabetic medicine. It reduces glucose production in the liver, decreases intestinal glucose absorption and improves insulin sensitivity, helping the body use glucose more effectively.

Together, these ingredients help lower blood glucose levels through complementary mechanisms.

✔️ Words of Advice:

• Follow a balanced eating plan recommended by your healthcare professional.
• Engage in regular physical activity as appropriate for your health.
• Monitor blood glucose as advised.
• Drink adequate fluids unless you have been instructed to restrict them.
• Avoid excessive alcohol consumption.
• Attend scheduled appointments for kidney function and other recommended monitoring.

✔️ Side Effects | Empaglif-M 5/500

• Diarrhea, nausea, vomiting and abdominal discomfort.
• Increased urination and thirst.
• Urinary tract infections.
• Genital fungal infections, including vaginal yeast infections and balanitis.
• Dehydration or low blood pressure.
• Low blood glucose, particularly when used with insulin or sulfonylureas.

✔️ Inform the physician about all medicines being taken. Important interactions include:

• Insulin and sulfonylureas: May increase the risk of hypoglycemia.
• Diuretics: May increase urination, dehydration and low blood pressure.
• Iodinated contrast agents: May affect kidney function and increase the risk of metformin-associated lactic acidosis in susceptible patients.
• Medicines affecting kidney function or metformin clearance: May increase the risk of adverse effects.
• Alcohol: Excessive consumption increases the risk of lactic acidosis and may destabilize blood glucose.

✔️ Directions for Use:

The dose and frequency must be determined by the physician according to the patient's blood glucose levels, kidney function, current treatment and the formulation prescribed.

• Take the tablet with meals if directed by the product instructions.
• Swallow it with water. Do not crush or chew a modified-release tablet.
• Take it at the same time each day as prescribed.
• Do not change the dose or stop treatment without medical advice.

✔️ Safety Information:

• Kidney function: Assess kidney function before starting treatment and monitor it periodically. The medicine may be unsuitable in severe kidney impairment.
• Lactic acidosis: Metformin can rarely cause a serious buildup of lactic acid, particularly in people with significant kidney impairment, severe dehydration, serious infection or excessive alcohol intake.
• Diabetic ketoacidosis: Empagliflozin may cause ketoacidosis even when blood glucose is not very high. Seek urgent care if symptoms develop.
• Dehydration: Maintain adequate fluid intake unless your healthcare professional has advised fluid restriction. Extra caution is required during hot weather, illness or fluid loss.
• Genital and urinary infections: Report symptoms promptly and maintain good personal hygiene.
• Vitamin B12: Long-term metformin use may lower vitamin B12 levels. Monitoring may be appropriate.
• Surgery and contrast imaging: Inform the treating team that you take this medicine. Temporary interruption may be necessary during surgery, prolonged fasting or certain imaging procedures involving iodinated contrast.
• Driving: Avoid driving if you experience dizziness, blurred vision or symptoms of low blood glucose.

✔️ Pregnancy and Breastfeeding

Empagliflozin is generally not recommended during pregnancy, particularly during the second and third trimesters, because of potential risks to fetal kidney development. Consult a healthcare professional promptly if pregnancy occurs or is planned.

Use during breastfeeding is generally not recommended. A healthcare professional should select an appropriate treatment for diabetes during pregnancy or lactation.

✔️ Empaglif-M 5/500 should not be used in patients with:

• Known hypersensitivity to empagliflozin, metformin or any component of the tablet.
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• Severe kidney impairment where metformin use is contraindicated.
• Certain acute conditions involving severe dehydration, shock or serious illness that may impair kidney function or oxygen delivery to tissues.

✔️ Storage Conditions

Store in the original packaging in a dry place, protected from excessive heat, moisture and direct light. Keep out of the reach of children. Follow the storage instructions printed on the product packaging.