Dexalev 0.1%+0.5% Eye Drops

✔️ Each mL of sterile ophthalmic solution contains:

• Dexamethasone 1 mg (as dexamethasone sodium phosphate USP)
• Levofloxacin 5 mg (as levofloxacin hemihydrate USP)
• Preservative: Benzalkonium chloride 0.005%

✔️ Side Effects:

• Eye irritation or discomfort
• Increased intraocular pressure
• Headache
• Temporary blurred vision
• Eye redness or irritation

Prolonged or inappropriate use may lead to more serious complications, including:

• Glaucoma
• Posterior subcapsular cataracts
• Delayed wound healing
• Corneal thinning or, rarely, perforation
• Secondary eye infections

✔️ Dexalev should not be used in patients with:

• Known hypersensitivity to dexamethasone, levofloxacin, or any other ingredient in the formulation
• Herpes simplex keratitis
• Varicella or other viral infections affecting the cornea or conjunctiva
• Mycobacterial infections of the eye
• Fungal infections of the ocular structures

✔️ How to Use Dexalev Eye Drop

1. Wash your hands thoroughly before applying the eye drops.
2. Remove the cap and, if applicable, the loose safety collar when opening the bottle for the first time.
3. Tilt your head backward and gently pull down the lower eyelid to create a small pocket.
4. Hold the bottle upside down and carefully instill one drop into the affected eye without touching the dropper tip to the eye, eyelids, fingers, or other surfaces.
5. Close your eye gently and apply light pressure to the inner corner of the eye near the nose for approximately one minute to reduce systemic absorption.
6. Close the bottle tightly after use.

✔️ Drug Interactions

Inform your doctor or pharmacist about all medicines you are currently using, including other eye drops and non-prescription products.

Important potential interactions include:

• Ophthalmic NSAIDs: Medicines such as ketorolac, diclofenac, bromfenac, and nepafenac may increase the risk of delayed or impaired corneal healing when used together with corticosteroid eye drops.
• Ritonavir and cobicistat: These medicines may increase systemic dexamethasone exposure.
• Probenecid: May affect the elimination of levofloxacin.
• Cimetidine: May alter levofloxacin elimination.
• Cyclosporine: May affect the pharmacokinetics of levofloxacin.

✔️ Pregnancy & Lactation

There is limited information about the safety of dexamethasone and levofloxacin ophthalmic preparations during pregnancy. Corticosteroids can cross the placenta, and prolonged or repeated systemic exposure may carry potential risks. Use during pregnancy should be considered only when the expected benefits outweigh the possible risks.

Both ingredients may enter breast milk following systemic exposure. Although systemic absorption from eye drops is generally limited, caution is recommended during breastfeeding. Consult your doctor before using Dexalev if you are pregnant, planning pregnancy, or breastfeeding.

✔️ Precautions & Warnings

• Dexalev is intended for ophthalmic use only and should not be swallowed or injected.
• Use the medicine only for the prescribed duration. Prolonged use may increase the risk of antibiotic resistance and overgrowth of non-susceptible organisms, including fungi.
• Extended use of ophthalmic corticosteroids may increase intraocular pressure and the risk of glaucoma.
• Patients with diabetes may have an increased risk of developing posterior subcapsular cataracts with prolonged topical corticosteroid use.
• Regular eye examinations may be necessary if treatment is extended beyond the recommended period.
• Discontinue treatment and seek medical advice if a new infection develops or symptoms worsen during therapy.

✔️ Dosage & Administration

Adults: Instill one drop into the affected eye every 6 hours for 7 days after surgery, or follow the exact dosage and duration prescribed by the ophthalmologist.

Children and Adolescents: Dexalev is not recommended for individuals under 18 years of age because its safety and effectiveness have not been sufficiently established in this age group.

✔️ Storage:

Store below 30°C in a dry place, protected from direct light. Keep out of the reach of children.

Avoid touching the dropper tip to any surface to prevent contamination. Close the bottle tightly after each application and discard it one month after opening, or according to the manufacturer's instructions.