Arotrix-C 5%+10% Lotion 60ml

✔️ Pharmacology

Arotrix-C Lotion contains Permethrin and Crotamiton.

Permethrin is a photostable synthetic pyrethroid with broad-spectrum insecticidal activity and relatively low toxicity in mammals. It acts primarily on the nervous system of mites and insects by affecting sodium channels in nerve cell membranes. This prolongs sodium permeability and causes abnormal nerve activity, leading to sensory hyperexcitability, paralysis, and eventual death of the mite.

Crotamiton is a topical antipruritic agent with activity against scabies mites. It also helps relieve itching associated with certain skin conditions.

✔️ Pharmacokinetics

Permethrin is administered topically. Systemic absorption through intact skin is low, with less than 0.5% of an applied dose reported to be absorbed during the first 48 hours. Absorbed permethrin is rapidly metabolized, mainly through ester hydrolysis, and its metabolites are primarily eliminated in the urine.

Crotamiton penetrates the skin rapidly. Small measurable concentrations may be detected in plasma several hours after topical application and generally decline thereafter.

✔️ Side Effects

• Burning sensation
• Stinging
• Tingling
• Redness (erythema)
• Swelling (edema)
• Rash
• Eczema
• Skin discomfort or irritation

✔️ Arotrix-C Lotion should not be used in individuals with known hypersensitivity to:

• Permethrin
• Crotamiton
• Other pyrethroids or pyrethrins
• Any component of the formulation

✔️ Precautions & Warnings

• For external use only.
• Avoid contact with the eyes.
• If the lotion accidentally enters the eyes, rinse immediately and thoroughly with clean water.
• Wash hands after application unless the hands are part of the treatment area.
• Healthcare workers who frequently apply the lotion may consider wearing protective gloves to minimize skin irritation.
• Do not apply to severely irritated or damaged skin unless specifically advised by a doctor.
• Persistent itching after successful scabies treatment does not necessarily mean that treatment has failed; itching may continue for some time because of the skin's reaction to the mites.
• If new burrows or active lesions continue to appear after treatment, consult a healthcare professional for further evaluation.

✔️ Interaction

Concomitant use of topical corticosteroids for eczema-like skin reactions should be discussed with a healthcare professional before treatment. Corticosteroids may suppress local immune responses and can potentially mask or alter the appearance of scabies.

Inform your doctor about all topical and oral medicines you are using.

✔️ Pregnancy & Lactation

There is limited information regarding the safety of the combination of Permethrin and Crotamiton during pregnancy. Pregnant women should consult their healthcare provider before using this medicine, particularly during early pregnancy.

It is not known whether sufficient amounts of the active ingredients pass into breast milk to affect a breastfed infant. Breastfeeding mothers should consult a healthcare professional before use.

Avoid applying the lotion directly to the nipple or surrounding area before breastfeeding.

✔️ Storage:

• Store below 25°C.
• Keep in a dry place.
• Protect from light.
• Keep out of reach of children.
• Keep the container tightly closed when not in use.