Leflox 500 | 1 Strip

✔️ Dosage & Administration

Adults

Acute sinusitis: 500 mg once daily for 10–14 days OR 750 mg once daily for 5 days

Chronic bronchitis exacerbation:

Uncomplicated: 500 mg once daily for 7 days OR 750 mg once daily for 3 days

Complicated: 750 mg once daily for 5 days

Community-acquired pneumonia: 500 mg once daily for 7–14 days OR 750 mg once daily for 5 days

Uncomplicated UTI: 250 mg once daily for 3 days

Complicated UTI & acute pyelonephritis: 250 mg once daily for 7–10 days

Uncomplicated skin infections: 500 mg once daily for 7–10 days

Complicated skin infections: 750 mg once daily for 7–14 days

Enteric fever: 500 mg once daily for 7–14 days

Diarrhea, cholera, shigellosis, enteritis:

Mild–moderate: single 500 mg dose

Moderate–severe: 500 mg once daily for 3 days

Pediatrics

6 months to <5 years: 10 mg/kg every 12 hours

5 years: 10 mg/kg every 24 hours

Routes

Tablets/Oral solution: May be taken with or without food (solution best 1 hr before or 2 hrs after meals).

✔️ Side Effects

Generally well tolerated.

• Common: Nausea, vomiting, diarrhea, abdominal pain, flatulence.
• Occasional: Phototoxicity (rare, ~0.1%).
• Rare: Tremors, anxiety, confusion, depression.
• Serious risk: Retinal detachment (very rare).

✔️ Drug Interactions

Avoid co-administration with antacids, iron, or adsorbents (reduce absorption).

NSAIDs may increase CNS stimulation risk.

Warfarin may increase bleeding risk.

Do not infuse quinolones with multivalent cation-containing solutions.

✔️ Contraindications:

Hypersensitivity to levofloxacin, other fluoroquinolones, or excipients.

✔️ Pregnancy & Lactation

Not recommended due to insufficient safety data.

✔️ Precautions & Warnings

• IV infusion must be slow (60–90 mins).
• Maintain hydration to avoid concentrated urine.
• Dose adjustment required in renal impairment.
• Use with caution in patients prone to seizures or CNS disorders.

✔️ Storage:

Store below 30°C, protected from light and moisture.

Keep out of reach of children.