Axim CV 500mg Tablet 1 Strip

✔️ Axim CV 500 contains two active ingredients:

Cefuroxime: A second-generation cephalosporin antibiotic. It binds to bacterial penicillin-binding proteins (PBPs) and inhibits the final stages of peptidoglycan synthesis, which is essential for bacterial cell-wall formation. This weakens the bacterial cell wall and leads to bacterial cell death.

Clavulanic Acid: A beta-lactamase inhibitor. Certain bacteria produce beta-lactamase enzymes that can break down beta-lactam antibiotics. Clavulanic acid inhibits some of these enzymes and can therefore help protect cefuroxime from enzymatic inactivation and extend its activity against certain susceptible beta-lactamase-producing bacteria.

✔️ Words of Advice:

• Axim CV 500 is an antibiotic for bacterial infections and does not treat viral infections such as the common cold or flu.
• Take it exactly as prescribed and do not use leftover antibiotics for another illness.
• Taking the medicine after food may help reduce stomach discomfort.
• Diarrhea can occur during treatment. Contact your doctor if it becomes severe, persistent, or bloody.
• Seek urgent medical attention if you develop an itchy widespread rash, facial/throat swelling, or breathing difficulty.
• Drink adequate fluids and take sufficient rest while recovering from an infection.
• Do not stop treatment or change the dose without consulting your doctor.

✔️ Side Effects

Common or possible side effects include:

• Diarrhea
• Nausea
• Vomiting
• Stomach discomfort or abdominal cramps
• Headache
• Skin rash
• Increased liver enzymes

Other less common effects may include:

• Eosinophilia
• Changes in blood counts
• Vaginal candidiasis
• Temporary increases in liver enzymes
• Urticaria
• Dizziness

Rare but serious reactions include:

• Severe allergic reaction or anaphylaxis
• Severe skin reactions such as Stevens-Johnson syndrome
• Antibiotic-associated or pseudomembranous colitis
• Liver inflammation or cholestatic jaundice
• Kidney inflammation or impairment
• Significant changes in blood counts

✔️ Axim CV 500 may interact with certain medicines, including:

• Probenecid: May increase and prolong cefuroxime concentrations.
• Aminoglycosides and potent diuretics such as furosemide: May increase the risk of kidney toxicity, particularly in susceptible patients.
• Oral anticoagulants: May increase anticoagulant effects in some patients; appropriate monitoring may be required.
• Oral contraceptives: Clinically significant reduction in contraceptive effectiveness is not generally expected with cefuroxime, but vomiting or severe diarrhea can interfere with oral contraceptive absorption.

✔️ Dosage and Administration

Take Axim CV 500 exactly according to your doctor's prescription. The appropriate dose and treatment duration depend on the type and severity of infection, age, kidney function, and clinical response.

Adults and Adolescents

Common cefuroxime-based regimens may include:

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days
• Acute bacterial sinusitis: 250 mg twice daily for approximately 10 days
• Acute bacterial exacerbation of chronic bronchitis: 250–500 mg twice daily
• Community-acquired pneumonia: 500 mg twice daily when clinically appropriate
• Uncomplicated urinary tract infections: 250 mg twice daily
• Skin and soft-tissue infections: 250–500 mg twice daily

Some infections require different doses or durations. Follow the exact regimen prescribed for your condition.

Children

Pediatric dosing is based primarily on body weight, age and the type of infection. Cefuroxime-based pediatric regimens may range from approximately 20–30 mg/kg/day in divided doses for selected infections.

Do not administer the adult 500 mg strength to a child unless specifically prescribed.

Kidney Impairment

Cefuroxime is primarily eliminated through the kidneys. Patients with significant renal impairment may require dosage or dosing-interval adjustment.

✔️ Use Axim CV 500 with caution in patients with:

• Severe kidney impairment
• A history of penicillin or other beta-lactam allergy
• Previous antibiotic-associated colitis
• Liver disease
• Conditions requiring prolonged antibiotic treatment

Prolonged antibiotic therapy may result in overgrowth of non-susceptible microorganisms, including fungi. If a superinfection develops, appropriate treatment should be initiated.

Cefuroxime may also interfere with certain laboratory tests, so inform healthcare professionals that you are taking this medicine before undergoing investigations.

✔️ Pregnancy and Breastfeeding

Pregnancy

Available clinical experience has not established a clear harmful effect of cefuroxime during pregnancy. However, Axim CV 500 should be used during pregnancy only when clearly indicated and prescribed by a healthcare professional.

Breastfeeding

Cefuroxime is excreted in small amounts into breast milk. It may be used during breastfeeding when clinically appropriate, but infants should be monitored for diarrhea, oral thrush or other unusual symptoms.

✔️ Axim CV 500 should not be used in patients with:

• Known hypersensitivity to cefuroxime or other cephalosporin antibiotics
• A history of severe immediate hypersensitivity to beta-lactam antibiotics, including penicillins, when considered clinically contraindicated