Febux 40mg Tablet 1 Strip

✔️ Dosage and Administration of Febuxostat

Adult dose: The usual starting dose is 40 mg once daily. Depending on serum uric acid levels and the applicable prescribing guidelines, the doctor may increase the dose to 80 mg daily.

1. Administration: Take the tablet as prescribed, at a consistent time each day. It may generally be taken with or without food.
2. Missed dose: Take the missed dose when remembered, unless it is nearly time for the next dose. Skip the missed dose if the next dose is due soon. Do not take two doses together.
3. Duration: Continue treatment as directed by your doctor, even when you are not experiencing a gout attack.

The appropriate dose may vary depending on kidney or liver function and the local product label. Do not adjust the dose yourself.

1. Renal impairment: Patients with severe kidney impairment may require additional caution because evidence and dosing recommendations are limited. Follow the prescribing physician's advice.
2. Hepatic impairment: Liver function should be assessed when clinically appropriate. Patients with severe liver impairment may require special consideration because evidence is limited.
3. Children: Safety and effectiveness have not been established for all pediatric populations. Use only under specialist guidance when indicated.

✔️ Side Effects: Febuxostat

• Nausea
• Diarrhoea
• Headache
• Skin rash
• Joint pain
• Increased liver enzyme levels

✔️ Interaction

Febuxostat can interact with certain medicines. Tell your doctor about all medicines you use, particularly:

• Azathioprine: Combining it with febuxostat is contraindicated because it may cause dangerous increases in azathioprine exposure.
• Mercaptopurine: Concomitant use is contraindicated because febuxostat can substantially increase drug levels and the risk of toxicity.
• Theophylline: Febuxostat may affect the metabolism of theophylline; medical assessment and monitoring may be necessary.

Do not start or stop any medicine without consulting your doctor.

✔️ Contraindications

Febuxostat should not be used with azathioprine or mercaptopurine. It is also unsuitable for patients with known hypersensitivity to febuxostat or any of the tablet's ingredients.

✔️ Pregnancy and Breastfeeding

Available information on febuxostat use during pregnancy is limited. It should be used only if a doctor determines that treatment is necessary after assessing the potential benefits and risks.

There is insufficient information about the presence of febuxostat in human breast milk and its effects on a breastfed infant. Consult your doctor before using this medicine while breastfeeding.

✔️ Precautions and Warnings

• Cardiovascular disease: Febuxostat has been associated with a higher rate of cardiovascular death than allopurinol in a study involving patients with established cardiovascular disease. Your doctor should assess the benefits and risks, especially if you have a history of heart attack, stroke, or other cardiovascular conditions.
• Liver problems: Liver function tests may be required before and during treatment.
• Kidney problems: Inform your doctor if you have kidney impairment, as monitoring and dose selection may need special consideration.
• Gout flare-ups: Attacks may temporarily increase when uric acid levels begin to fall. Do not stop treatment on your own; contact your doctor for advice about managing the flare.
• Lifestyle: Maintain a balanced diet, limit alcohol, avoid dehydration, and discuss dietary changes with your healthcare professional.

✔️ Storage:

• Store in a cool, dry place according to the instructions on the packaging.
• Protect from excessive heat and moisture.
• Keep out of reach of children.
• Do not use after the expiry date.