Ornova is prescribed for the treatment of:
- Elderly: Use cautiously due to reduced hepatic/renal function.
- Children (<18 years): Not recommended (safety and efficacy unestablished).
- Renal impairment: No adjustment needed in mild–moderate impairment (eGFR 30–89 mL/min). Avoid in severe impairment (eGFR <30 mL/min).
- Hepatic impairment: Safe in mild impairment (Child-Pugh A). Avoid in moderate–severe impairment (Child-Pugh B or C).
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Vonoprazan is a potassium-competitive acid blocker (P-CAB) that directly inhibits H+, K+-ATPase in a reversible and potassium-dependent manner, without the need for acid activation. Its strong basicity allows it to localize at the acid-secreting sites of gastric parietal cells, producing potent and long-lasting inhibition of gastric acid secretion. This results in effective protection against upper gastrointestinal mucosal damage.
As part of combination therapy for Helicobacter pylori eradication in conditions such as gastric/duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, post-endoscopic resection of early gastric cancer, or H. pylori gastritis.
ওয়েবসাইট থেকে অর্ডার করার সহজ ভিডিও গাইড।
অ্যাপ থেকে অর্ডারের সহজ ভিডিও গাইড
অ্যাপ ডাউনলোডePharma অ্যাপ ডাউনলোড বিস্তারিত গাইড ›অ্যাপে অর্ডারের বিস্তারিত গাইডPossible adverse reactions include:
Gastric ulcer: 20 mg once daily for 8 weeks
Duodenal ulcer: 20 mg once daily for 6 weeks
Reflux esophagitis: 20 mg once daily for 4 weeks (extendable to 8 weeks if needed)
Maintenance of reflux esophagitis: 10 mg once daily (may be increased to 20 mg if required)
Prevention of ulcer recurrence (aspirin or NSAID use): 10 mg once daily
H. pylori eradication (first-line): 20 mg vonoprazan + 750 mg amoxicillin + 200 mg clarithromycin, all taken twice daily for 7 days (clarithromycin may be increased up to 400 mg twice daily if necessary).
H. pylori eradication (alternative): 20 mg vonoprazan + 750 mg amoxicillin + 250 mg metronidazole, all taken twice daily for 7 days.
Ornova can be taken with or without food.
Known hypersensitivity to vonoprazan or any component of the formulation
Concomitant use with atazanavir, nelfinavir, or rilpivirine
Store below 30°C in a cool, dry place, away from light. Keep out of reach of children.
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