Monotherapy & Combination Therapy: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Limitations of Use:
Not indicated for type 1 diabetes mellitus or diabetic ketoacidosis.
Safety and efficacy have not been established in patients with a history of pancreatitis. It is unknown whether such patients are at higher risk of developing pancreatitis with Sitap.
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Sitagliptin is a DPP-4 inhibitor that prolongs the activity of incretin hormones (GLP-1 and GIP), which play a role in glucose homeostasis.
Increases insulin synthesis and release from pancreatic β-cells in a glucose-dependent manner.
Reduces glucagon secretion from pancreatic α-cells, lowering hepatic glucose production.
Highly selective for DPP-4, with minimal effect on DPP-8 or DPP-9.
Pediatric: Safety and efficacy not established (<18 years).
Geriatric: Use with caution due to potential renal impairment. Monitor renal function regularly.
ওয়েবসাইট থেকে অর্ডার করার সহজ ভিডিও গাইড।
অ্যাপ থেকে অর্ডারের সহজ ভিডিও গাইড
অ্যাপ ডাউনলোডePharma অ্যাপ ডাউনলোড বিস্তারিত গাইড ›অ্যাপে অর্ডারের বিস্তারিত গাইডUsual dose: 100 mg once daily, or 50 mg twice daily.
May be taken with or without food.
Renal Impairment Adjustments:
Mild (CrCl ≥50 mL/min): No adjustment required.
Moderate (CrCl ≥30 to <50 mL/min): 50 mg once daily.
Severe (CrCl <30 mL/min) or ESRD on dialysis: 25 mg once daily.
No significant effect on the pharmacokinetics of: metformin, glyburide, simvastatin, rosiglitazone, warfarin, oral contraceptives.
Digoxin: Slight increase in serum concentration, but no dose adjustment required.
History of serious hypersensitivity reactions to sitagliptin (e.g., anaphylaxis, angioedema).
Common: Headache, nasopharyngitis, upper respiratory tract infection.
Combination therapy risk: Hypoglycemia when used with sulfonylurea or insulin.
Pregnancy: Category B – use only if clearly needed.
Lactation: Excreted in rat milk; unknown in humans. Use caution in nursing mothers.
Pancreatitis: Discontinue immediately if suspected.
Renal impairment: Dose adjustments required.
Hypoglycemia risk: Reduce dose of sulfonylurea or insulin when used in combination.
Hypersensitivity: Post-marketing reports include anaphylaxis, angioedema, and severe cutaneous reactions (e.g., Stevens-Johnson syndrome). Discontinue if reaction occurs.
Store below 25°C, in a dry place away from light.
Keep out of reach of children.
Dispense only with a registered physician’s prescription.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.